Acvr1 activin A receptor type 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Acvr1provided by RGD
Official Full Name: activin A receptor type 1provided by RGD
Primary source: RGD:620200
See related: EnsemblRapid:ENSRNOG00000005033 AllianceGenome:RGD:620200
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables activin receptor activity, type I. Involved in cellular response to glucocorticoid stimulus; regulation of skeletal muscle tissue development; and transforming growth factor beta receptor signaling pathway. Acts upstream of or within urogenital system development. Part of activin receptor complex. Human ortholog(s) of this gene implicated in exfoliation syndrome; fibrodysplasia ossificans progressiva; primary angle-closure glaucoma; and primary open angle glaucoma. Orthologous to human ACVR1 (activin A receptor type 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 32.9), Kidney (RPKM 31.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q21

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (63387378..63506980, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (42978558..43097892, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (44432476..44539680, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Suggest that BMP signaling upregulates the calcineurin/nuclear factor of activated T cell pathway via BMP type I receptor ALK2, contributing to cardiac hypertrophy and fibrosis.
Title: BMP type I receptor ALK2 is required for angiotensin II-induced cardiac hypertrophy.
Up-regulation of activin betaA and activin type I receptor A mRNA was observed in response to injury. Activin betaA mRNA levels in the cortex increased with time and estradiol replacement did not influence this increase.
Title: Stroke injury in rats causes an increase in activin A gene expression which is unaffected by oestradiol treatment.
In a rat model of HF, we demonstrated a concerted induction of the gene expression of activin betaA and activin receptors IA, IB, IIA, and IIB after myocardial infarction.
Title: Elevated levels of activin A in heart failure: potential role in myocardial remodeling.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH138112 (e-PCR)
- UniSTS:220199

BF401349 (e-PCR)
- UniSTS:245464

Acvr1 (e-PCR), detects polymorphism
- UniSTS:233950

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables BMP receptor activity	IEA Inferred from Electronic Annotation more info
enables BMP receptor activity	ISO Inferred from Sequence Orthology more info
enables SMAD binding	IBA Inferred from Biological aspect of Ancestor more info
enables SMAD binding	IEA Inferred from Electronic Annotation more info
enables SMAD binding	ISO Inferred from Sequence Orthology more info
enables activin binding	IEA Inferred from Electronic Annotation more info
enables activin binding	ISO Inferred from Sequence Orthology more info
enables activin receptor activity, type I	IDA Inferred from Direct Assay more info	PubMed
enables activin receptor activity, type I	IEA Inferred from Electronic Annotation more info
contributes_to activin receptor activity, type I	ISO Inferred from Sequence Orthology more info
enables activin receptor activity, type I	ISO Inferred from Sequence Orthology more info
enables cadherin binding	IEA Inferred from Electronic Annotation more info
enables cadherin binding	ISO Inferred from Sequence Orthology more info
enables growth factor binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase binding	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase binding	ISO Inferred from Sequence Orthology more info
enables transforming growth factor beta binding	IEA Inferred from Electronic Annotation more info
enables transforming growth factor beta binding	ISO Inferred from Sequence Orthology more info
enables transforming growth factor beta receptor activity	IEA Inferred from Electronic Annotation more info
enables transforming growth factor beta receptor activity, type I	IBA Inferred from Biological aspect of Ancestor more info
enables transforming growth factor beta receptor activity, type I	ISO Inferred from Sequence Orthology more info
enables transmembrane receptor protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables transmembrane receptor protein serine/threonine kinase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in BMP signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in activin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in activin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in acute inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in atrial septum primum morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in atrial septum primum morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in atrioventricular valve morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within branching involved in blood vessel morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle cell fate commitment	IEA Inferred from Electronic Annotation more info
involved_in cardiac muscle cell fate commitment	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor protein serine/threonine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell surface receptor protein serine/threonine kinase signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to BMP stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glucocorticoid stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to growth factor stimulus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within determination of left/right symmetry	ISO Inferred from Sequence Orthology more info
involved_in dorsal/ventral pattern formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in embryonic heart tube morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in embryonic heart tube morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in endocardial cushion cell fate commitment	IEA Inferred from Electronic Annotation more info
involved_in endocardial cushion cell fate commitment	ISO Inferred from Sequence Orthology more info
involved_in endocardial cushion formation	ISO Inferred from Sequence Orthology more info
involved_in endocardial cushion fusion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gastrulation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gastrulation with mouth forming second	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within germ cell development	ISO Inferred from Sequence Orthology more info
involved_in heart development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mesoderm development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mesoderm formation	ISO Inferred from Sequence Orthology more info
involved_in mitral valve morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in mitral valve morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of G1/S transition of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of activin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of activin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of extrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neural crest cell migration	ISO Inferred from Sequence Orthology more info
NOT involved_in outflow tract septum morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pharyngeal system development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of SMAD protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of bone mineralization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cardiac epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of determination of dorsal identity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of determination of dorsal identity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoblast differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	TAS Traceable Author Statement more info	PubMed
involved_in regulation of ossification	ISO Inferred from Sequence Orthology more info
involved_in regulation of skeletal muscle tissue development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within smooth muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in transforming growth factor beta receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in transforming growth factor beta receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in transforming growth factor beta receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within urogenital system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ventricular septum morphogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of BMP receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of activin receptor complex	IDA Inferred from Direct Assay more info	PubMed
part_of activin receptor complex	IEA Inferred from Electronic Annotation more info
part_of activin receptor complex	ISO Inferred from Sequence Orthology more info
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: activin receptor type-1

Names: ACTR-I; ALK2-B; SKR1; TGF-B superfamily receptor type I; TSR-I; activin A receptor, type I; activin receptor type I; activin type I receptor; serine/threonine-protein kinase receptor R1

NP_077812.1

EC 2.7.11.30

XP_008760089.1

EC 2.7.11.30

XP_038961824.1

EC 2.7.11.30

XP_038961826.1

EC 2.7.11.30

XP_038961827.1

EC 2.7.11.30

XP_038961830.1

EC 2.7.11.30

XP_038961832.1

EC 2.7.11.30

XP_038961834.1

EC 2.7.11.30

XP_063140678.1

EC 2.7.11.30

XP_063140679.1

EC 2.7.11.30

XP_063140680.1

EC 2.7.11.30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001431445.1 → NP_001418374.1 activin receptor type-1 isoform a precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

P80201

UniProtKB/TrEMBL

B3DM96
NM_001431446.1 → NP_001418375.1 activin receptor type-1 isoform b precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A0G2K2P7
NM_024486.2 → NP_077812.1 activin receptor type-1 isoform a precursor

See identical proteins and their annotated locations for NP_077812.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

P80201

UniProtKB/TrEMBL

A6JF58, B3DM96

Conserved Domains (3) summary

cd14142
Location:202 → 499

STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1

pfam01064
Location:37 → 102

Activin_recp; Activin types I and II receptor domain

pfam08515
Location:179 → 206

TGF_beta_GS; Transforming growth factor beta type I GS-motif

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

63387378..63506980 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039105904.2 → XP_038961832.1 activin receptor type-1 isoform X3

Related

ENSRNOP00000006963.4, ENSRNOT00000006963.5

Conserved Domains (3) summary

cd14142
Location:202 → 499

STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1

pfam01064
Location:37 → 102

Activin_recp; Activin types I and II receptor domain

pfam08515
Location:179 → 206

TGF_beta_GS; Transforming growth factor beta type I GS-motif
XM_039105896.2 → XP_038961824.1 activin receptor type-1 isoform X1

Related

ENSRNOP00000072326.1, ENSRNOT00000087071.3

Conserved Domains (3) summary

cd14142
Location:221 → 518

STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1

pfam01064
Location:56 → 121

Activin_recp; Activin types I and II receptor domain

pfam08515
Location:198 → 225

TGF_beta_GS; Transforming growth factor beta type I GS-motif
XM_039105906.2 → XP_038961834.1 activin receptor type-1 isoform X4

UniProtKB/TrEMBL

A6JF58

Related

ENSRNOP00000112797.1, ENSRNOT00000137840.1

Conserved Domains (3) summary

cd14142
Location:185 → 482

STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1

pfam01064
Location:20 → 85

Activin_recp; Activin types I and II receptor domain

pfam08515
Location:162 → 189

TGF_beta_GS; Transforming growth factor beta type I GS-motif
XM_008761867.3 → XP_008760089.1 activin receptor type-1 isoform X2

UniProtKB/TrEMBL

A6JF58

Related

ENSRNOP00000102110.1, ENSRNOT00000160344.1

Conserved Domains (4) summary

smart00220
Location:211 → 495

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14142
Location:204 → 501

STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1

pfam01064
Location:35 → 104

Activin_recp; Activin types I and II receptor domain

pfam08515
Location:181 → 208

TGF_beta_GS; Transforming growth factor beta type I GS-motif
XM_063284610.1 → XP_063140680.1 activin receptor type-1 isoform X3
XM_039105899.2 → XP_038961827.1 activin receptor type-1 isoform X1

UniProtKB/TrEMBL

A0A0G2K2P7, A6JF58

Conserved Domains (3) summary

cd14142
Location:221 → 518

STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1

pfam01064
Location:56 → 121

Activin_recp; Activin types I and II receptor domain

pfam08515
Location:198 → 225

TGF_beta_GS; Transforming growth factor beta type I GS-motif
XM_063284608.1 → XP_063140678.1 activin receptor type-1 isoform X1

UniProtKB/TrEMBL

A0A0G2K2P7
XM_063284609.1 → XP_063140679.1 activin receptor type-1 isoform X1

UniProtKB/TrEMBL

A0A0G2K2P7
XM_039105898.2 → XP_038961826.1 activin receptor type-1 isoform X1

UniProtKB/TrEMBL

A0A0G2K2P7, A6JF58

Conserved Domains (3) summary

cd14142
Location:221 → 518

STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1

pfam01064
Location:56 → 121

Activin_recp; Activin types I and II receptor domain

pfam08515
Location:198 → 225

TGF_beta_GS; Transforming growth factor beta type I GS-motif
XM_039105902.2 → XP_038961830.1 activin receptor type-1 isoform X1

UniProtKB/TrEMBL

A0A0G2K2P7, A6JF58

Conserved Domains (3) summary

cd14142
Location:221 → 518

STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1

pfam01064
Location:56 → 121

Activin_recp; Activin types I and II receptor domain

pfam08515
Location:198 → 225

TGF_beta_GS; Transforming growth factor beta type I GS-motif