GSTK1 glutathione S-transferase kappa 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: GSTK1provided by HGNC
Official Full Name: glutathione S-transferase kappa 1provided by HGNC
Primary source: HGNC:HGNC:16906
See related: Ensembl:ENSG00000197448 MIM:602321; AllianceGenome:HGNC:16906
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GST; GST13; hGSTK1; GSTK1-1; GST13-13; GST 13-13
Summary: This gene encodes a member of the kappa class of the glutathione transferase superfamily of enzymes that function in cellular detoxification. The encoded protein is localized to the peroxisome and catalyzes the conjugation of glutathione to a wide range of hydrophobic substates facilitating the removal of these compounds from cells. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009]
Expression: Ubiquitous expression in duodenum (RPKM 118.1), small intestine (RPKM 106.3) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 7q34

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (143263441..143269115)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (144618862..144624534)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (142960534..142966208)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

New insights of DsbA-L in the pathogenesis of metabolic diseases.
Title: New insights of DsbA-L in the pathogenesis of metabolic diseases.
[Multifaceted Clinical Research on Obesity-related Disease Prevention Focusing on the DsbA-L Gene].
Title: [Multifaceted Clinical Research on Obesity-related Disease Prevention Focusing on the DsbA-L Gene].
T cell metabolism in obesity and beyond: comments on 'DsbA-L deficiency in T cells promotes diet-induced thermogenesis through suppressing IFN-gamma production'.
Title: T cell metabolism in obesity and beyond: comments on 'DsbA-L deficiency in T cells promotes diet-induced thermogenesis through suppressing IFN-γ production'.
Silencing of DsbA-L gene impairs the PPARgamma agonist function of improving insulin resistance in a high-glucose cell model.
Title: Silencing of DsbA-L gene impairs the PPARγ agonist function of improving insulin resistance in a high-glucose cell model.
Plasma mtDNA copy numbers are associated with GSTK1 expression and inflammation in type 2 diabetes.
Title: Plasma mtDNA copy numbers are associated with GSTK1 expression and inflammation in type 2 diabetes.
The DsbA-L gene is associated with respiratory function of the elderly via its adiponectin multimeric or antioxidant properties.
Title: The DsbA-L gene is associated with respiratory function of the elderly via its adiponectin multimeric or antioxidant properties.
DsbA-L mediated renal tubulointerstitial fibrosis in UUO mice.
Title: DsbA-L mediated renal tubulointerstitial fibrosis in UUO mice.
DsbA-L modifies mtROS/JNK/MFF-related mitochondrial fission, linking alterations in mitochondrial dynamics during tubular injury in the pathogenesis of diabetic kidney disease.
Title: DsbA-L deficiency exacerbates mitochondrial dysfunction of tubular cells in diabetic kidney disease.
DsbA-L plays a critical protective role in renal ectopic fat deposition and lipid-related kidney injury in mice with diabetic nephropathy (DN) and patients with DN. The mechanisms might involve the inhibition of cholesterol synthesis through the inactivation of HMGCR and the promotion of lipolysis through the activation of ATGL and the subsequent reduction of lipid droplets accumulation in the kidney.
Title: Disulfide-bond A oxidoreductase-like protein protects against ectopic fat deposition and lipid-related kidney damage in diabetic nephropathy.
The population prediction model of BMI indicated that the DsbA-L T/T genotype was significantly associated with a high BMI. The BMI-based NAFLD prediction model showed that the DsbA-L T/T genotype did not have any direct impact on the risk of NAFLD, whereas the structural equation model suggested that this genotype might be indirectly or partially associated with NAFLD risk through a high BMI and low adiponectin.
Title: Modeling of the Weight Status and Risk of Nonalcoholic Fatty Liver Disease in Elderly Individuals: The Potential Impact of the Disulfide Bond-Forming Oxidoreductase A-Like Protein (DsbA-L) Polymorphism on the Weight Status.

Submit: New GeneRIF Correction See all GeneRIFs (29)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Vpr	vpr	A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of glutathione S-transferase kappa 1 (GSTK1) expression by HIV-1 Vpr in Vpr transduced macrophages	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

A009K20 (e-PCR)
- UniSTS:77377

STS-D20042 (e-PCR)
- UniSTS:17491

RH80030 (e-PCR)
- UniSTS:87680

G32613 (e-PCR)
- UniSTS:117196

RH36256 (e-PCR)
- UniSTS:15327

WI-11576 (e-PCR)
- UniSTS:66045

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables glutathione peroxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione peroxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables glutathione transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in epithelial cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in glutathione metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed
located_in membrane	HDA more info	PubMed
located_in mitochondrial matrix	TAS Traceable Author Statement more info
located_in mitochondrion	HTP more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisomal matrix	TAS Traceable Author Statement more info
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: glutathione S-transferase kappa 1

Names: GST class-kappa; glutathione S-transferase k1; glutathione S-transferase subunit 13 homolog

NP_001137151.1

EC 2.5.1.18

NP_001137152.1

EC 2.5.1.18

NP_001137153.1

EC 2.5.1.18

NP_057001.1

EC 2.5.1.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001143679.2 → NP_001137151.1 glutathione S-transferase kappa 1 isoform b

See identical proteins and their annotated locations for NP_001137151.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded protein (isoform b) is longer compared to isoform a.

Source sequence(s)

BC063425, BQ436828

Consensus CDS

CCDS47730.1

UniProtKB/Swiss-Prot

Q9Y2Q3

Related

ENSP00000431049.1, ENST00000479303.1

Conserved Domains (1) summary

cd03021
Location:6 → 267

DsbA_GSTK; DsbA family, Glutathione (GSH) S-transferase Kappa (GSTK) subfamily; GSTK is a member of the GST family of enzymes which catalyzes the transfer of the thiol of GSH to electrophilic substrates. It is specifically located in the mitochondria and ...
NM_001143680.2 → NP_001137152.1 glutathione S-transferase kappa 1 isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an exon in the coding region compared to variant 1. The encoded protein (isoform c) is shorter compared to isoform a.

Source sequence(s)

AC073342, AK299968, BQ436828

Consensus CDS

CCDS47731.1

UniProtKB/Swiss-Prot

Q9Y2Q3

Related

ENSP00000386944.3, ENST00000409500.7

Conserved Domains (1) summary

cd03021
Location:6 → 199

DsbA_GSTK; DsbA family, Glutathione (GSH) S-transferase Kappa (GSTK) subfamily; GSTK is a member of the GST family of enzymes which catalyzes the transfer of the thiol of GSH to electrophilic substrates. It is specifically located in the mitochondria and ...
NM_001143681.2 → NP_001137153.1 glutathione S-transferase kappa 1 isoform d

See identical proteins and their annotated locations for NP_001137153.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks an exon in the coding region compared to variant 1. The encoded protein (isoform d) is shorter compared to isoform a.

Source sequence(s)

AK295592, BC001231

Consensus CDS

CCDS47732.1

UniProtKB/Swiss-Prot

Q9Y2Q3

Related

ENSP00000415813.2, ENST00000443571.6

Conserved Domains (1) summary

cl00388
Location:6 → 168

Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
NM_015917.3 → NP_057001.1 glutathione S-transferase kappa 1 isoform a

See identical proteins and their annotated locations for NP_057001.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the predominant isoform (a).

Source sequence(s)

AL136938, BQ436828

Consensus CDS

CCDS5877.1

UniProtKB/Swiss-Prot

B4DIH1, B4DSY2, Q6P4H0, Q7Z520, Q9P1S4, Q9Y2Q3

UniProtKB/TrEMBL

Q6FII1

Related

ENSP00000351181.5, ENST00000358406.10

Conserved Domains (1) summary

cd03021
Location:6 → 211

DsbA_GSTK; DsbA family, Glutathione (GSH) S-transferase Kappa (GSTK) subfamily; GSTK is a member of the GST family of enzymes which catalyzes the transfer of the thiol of GSH to electrophilic substrates. It is specifically located in the mitochondria and ...