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    TEAD2 TEA domain transcription factor 2 [ Homo sapiens (human) ]

    Gene ID: 8463, updated on 2-Nov-2024

    Summary

    Official Symbol
    TEAD2provided by HGNC
    Official Full Name
    TEA domain transcription factor 2provided by HGNC
    Primary source
    HGNC:HGNC:11715
    See related
    Ensembl:ENSG00000074219 MIM:601729; AllianceGenome:HGNC:11715
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ETF; TEF4; TEF-4; TEAD-2
    Summary
    Enables several functions, including DNA-binding transcription factor activity; disordered domain specific binding activity; and transcription coactivator binding activity. Involved in hippo signaling; positive regulation of DNA-templated transcription; and protein-containing complex assembly. Located in cytosol and nucleoplasm. Part of TEAD-YAP complex. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in endometrium (RPKM 17.4), ovary (RPKM 10.9) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See TEAD2 in Genome Data Viewer
    Location:
    19q13.33
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (49340595..49362416, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (52338023..52359872, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (49843852..49865673, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene SUMO1 pseudogene 4 Neighboring gene solute carrier family 6 member 16 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14930 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:49816848-49817070 Neighboring gene microRNA 4324 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14931 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:49830555-49830706 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14932 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14933 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14934 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14935 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49842721-49843696 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14936 Neighboring gene CD37 molecule Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:49863002-49863502 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:49864048-49864757 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49864758-49865466 Neighboring gene uncharacterized LOC101928295 Neighboring gene dickkopf like acrosomal protein 1 Neighboring gene KASH domain containing 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14937 Neighboring gene uncharacterized LOC124904740 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49918083-49918637 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49918638-49919191

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in cellular response to retinoic acid  
    involved_in embryonic heart tube morphogenesis  
    involved_in embryonic organ development  
    involved_in hippo signaling  
    involved_in hippo signaling PubMed 
    involved_in lateral mesoderm development  
    involved_in neural tube closure  
    involved_in notochord development  
    involved_in paraxial mesoderm development  
    involved_in positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in protein-containing complex assembly PubMed 
    involved_in regulation of DNA-templated transcription PubMed 
    involved_in regulation of stem cell differentiation  
    involved_in regulation of transcription by RNA polymerase II  
    involved_in transcription by RNA polymerase II  
    involved_in vasculogenesis  
    Component Evidence Code Pubs
    part_of TEAD-YAP complex PubMed 
    located_in chromatin  
    located_in cytosol  
    located_in intracellular membrane-bounded organelle  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus PubMed 
    part_of transcription regulator complex  

    General protein information

    Preferred Names
    transcriptional enhancer factor TEF-4
    Names
    TEA domain family member 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256658.2NP_001243587.1  transcriptional enhancer factor TEF-4 isoform 1

      See identical proteins and their annotated locations for NP_001243587.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      BC007556, BC051301, BG334109
      Consensus CDS
      CCDS58671.1
      Related
      ENSP00000469672.1, ENST00000601519.5
      Conserved Domains (2) summary
      smart00426
      Location:40107
      TEA; TEA domain
      pfam17725
      Location:229447
      YBD; YAP binding domain
    2. NM_001256659.2NP_001243588.1  transcriptional enhancer factor TEF-4 isoform 1

      See identical proteins and their annotated locations for NP_001243588.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AK290736, BC007556
      Consensus CDS
      CCDS58671.1
      Related
      ENSP00000366419.4, ENST00000377214.8
      Conserved Domains (2) summary
      smart00426
      Location:40107
      TEA; TEA domain
      pfam17725
      Location:229447
      YBD; YAP binding domain
    3. NM_001256660.2NP_001243589.1  transcriptional enhancer factor TEF-4 isoform 2

      See identical proteins and their annotated locations for NP_001243589.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, contains an alternate exon and uses an alternate splice site in the 5' coding region, but maintains the reading frame, compared to variant 1. Variants 3 and 4 encode the same isoform (2), which is longer than isoform 1.
      Source sequence(s)
      AL832240, BC007556, BG334109
      Consensus CDS
      CCDS59406.1
      Related
      ENSP00000469640.2, ENST00000593945.6
      Conserved Domains (2) summary
      smart00426
      Location:40107
      TEA; TEA domain
      pfam17725
      Location:230448
      YBD; YAP binding domain
    4. NM_001256661.2NP_001243590.1  transcriptional enhancer factor TEF-4 isoform 2

      See identical proteins and their annotated locations for NP_001243590.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, contains an alternate exon and uses an alternate splice site in the 5' coding region, but maintains the reading frame, compared to variant 1. Variants 3 and 4 encode the same isoform (2), which is longer than isoform 1.
      Source sequence(s)
      AC010524, BC007556, BC018803
      Consensus CDS
      CCDS59406.1
      Related
      ENSP00000472109.1, ENST00000598810.5
      Conserved Domains (2) summary
      smart00426
      Location:40107
      TEA; TEA domain
      pfam17725
      Location:230448
      YBD; YAP binding domain
    5. NM_001256662.2NP_001243591.1  transcriptional enhancer factor TEF-4 isoform 4

      See identical proteins and their annotated locations for NP_001243591.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and has multiple differences in the coding region, including the use of a downstream, in-frame start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AK300241, BC007556
      Consensus CDS
      CCDS58670.1
      UniProtKB/Swiss-Prot
      Q15562
      Related
      ENSP00000437928.1, ENST00000539846.5
    6. NM_003598.2NP_003589.1  transcriptional enhancer factor TEF-4 isoform 3

      See identical proteins and their annotated locations for NP_003589.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate splice site in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      BC007556
      Consensus CDS
      CCDS12761.1
      UniProtKB/Swiss-Prot
      B4DTJ6, M0R1T9, Q15562, Q8NA25, Q96IG3
      Related
      ENSP00000310701.1, ENST00000311227.6
      Conserved Domains (1) summary
      smart00426
      Location:40107
      TEA; TEA domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      49340595..49362416 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047439541.1XP_047295497.1  transcriptional enhancer factor TEF-4 isoform X9

    2. XM_047439538.1XP_047295494.1  transcriptional enhancer factor TEF-4 isoform X8

    3. XM_047439537.1XP_047295493.1  transcriptional enhancer factor TEF-4 isoform X7

    4. XM_047439535.1XP_047295491.1  transcriptional enhancer factor TEF-4 isoform X6

    5. XM_047439523.1XP_047295479.1  transcriptional enhancer factor TEF-4 isoform X2

    6. XM_011527404.3XP_011525706.1  transcriptional enhancer factor TEF-4 isoform X5

      Conserved Domains (1) summary
      smart00426
      Location:40107
      TEA; TEA domain
    7. XM_011527399.3XP_011525701.1  transcriptional enhancer factor TEF-4 isoform X1

      See identical proteins and their annotated locations for XP_011525701.1

      Conserved Domains (1) summary
      smart00426
      Location:40107
      TEA; TEA domain
    8. XM_047439544.1XP_047295500.1  transcriptional enhancer factor TEF-4 isoform X10

    9. XM_047439543.1XP_047295499.1  transcriptional enhancer factor TEF-4 isoform X9

    10. XM_047439539.1XP_047295495.1  transcriptional enhancer factor TEF-4 isoform X8

    11. XM_047439528.1XP_047295484.1  transcriptional enhancer factor TEF-4 isoform X4

      UniProtKB/Swiss-Prot
      B4DTJ6, M0R1T9, Q15562, Q8NA25, Q96IG3
    12. XM_011527403.2XP_011525705.1  transcriptional enhancer factor TEF-4 isoform X3

      See identical proteins and their annotated locations for XP_011525705.1

      Conserved Domains (2) summary
      smart00426
      Location:40107
      TEA; TEA domain
      pfam17725
      Location:229447
      YBD; YAP binding domain
    13. XM_011527400.3XP_011525702.1  transcriptional enhancer factor TEF-4 isoform X1

      See identical proteins and their annotated locations for XP_011525702.1

      Conserved Domains (1) summary
      smart00426
      Location:40107
      TEA; TEA domain
    14. XM_047439532.1XP_047295488.1  transcriptional enhancer factor TEF-4 isoform X4

      UniProtKB/Swiss-Prot
      B4DTJ6, M0R1T9, Q15562, Q8NA25, Q96IG3
    15. XM_047439522.1XP_047295478.1  transcriptional enhancer factor TEF-4 isoform X1

    16. XM_047439542.1XP_047295498.1  transcriptional enhancer factor TEF-4 isoform X9

    17. XM_047439540.1XP_047295496.1  transcriptional enhancer factor TEF-4 isoform X8

    18. XM_047439531.1XP_047295487.1  transcriptional enhancer factor TEF-4 isoform X4

      UniProtKB/Swiss-Prot
      B4DTJ6, M0R1T9, Q15562, Q8NA25, Q96IG3
    19. XM_047439526.1XP_047295482.1  transcriptional enhancer factor TEF-4 isoform X3

    20. XM_011527402.2XP_011525704.1  transcriptional enhancer factor TEF-4 isoform X1

      See identical proteins and their annotated locations for XP_011525704.1

      Conserved Domains (1) summary
      smart00426
      Location:40107
      TEA; TEA domain
    21. XM_047439530.1XP_047295486.1  transcriptional enhancer factor TEF-4 isoform X4

      UniProtKB/Swiss-Prot
      B4DTJ6, M0R1T9, Q15562, Q8NA25, Q96IG3
    22. XM_047439527.1XP_047295483.1  transcriptional enhancer factor TEF-4 isoform X3

    23. XM_047439533.1XP_047295489.1  transcriptional enhancer factor TEF-4 isoform X5

    24. XM_047439521.1XP_047295477.1  transcriptional enhancer factor TEF-4 isoform X1

    25. XM_047439529.1XP_047295485.1  transcriptional enhancer factor TEF-4 isoform X4

      UniProtKB/Swiss-Prot
      B4DTJ6, M0R1T9, Q15562, Q8NA25, Q96IG3
    26. XM_047439525.1XP_047295481.1  transcriptional enhancer factor TEF-4 isoform X3

    27. XM_047439524.1XP_047295480.1  transcriptional enhancer factor TEF-4 isoform X2

    28. XM_005259334.5XP_005259391.1  transcriptional enhancer factor TEF-4 isoform X9

      Conserved Domains (1) summary
      smart00426
      Location:40107
      TEA; TEA domain
    29. XM_006723428.4XP_006723491.1  transcriptional enhancer factor TEF-4 isoform X8

      Conserved Domains (1) summary
      smart00426
      Location:40107
      TEA; TEA domain
    30. XM_047439536.1XP_047295492.1  transcriptional enhancer factor TEF-4 isoform X7

    31. XM_047439534.1XP_047295490.1  transcriptional enhancer factor TEF-4 isoform X6

    32. XM_047439520.1XP_047295476.1  transcriptional enhancer factor TEF-4 isoform X1

    33. XM_011527401.1XP_011525703.1  transcriptional enhancer factor TEF-4 isoform X1

      See identical proteins and their annotated locations for XP_011525703.1

      Conserved Domains (1) summary
      smart00426
      Location:40107
      TEA; TEA domain
    34. XM_006723429.2XP_006723492.1  transcriptional enhancer factor TEF-4 isoform X11

    35. XM_011527406.4XP_011525708.1  transcriptional enhancer factor TEF-4 isoform X13

      Conserved Domains (1) summary
      smart00426
      Location:40107
      TEA; TEA domain
    36. XM_011527405.4XP_011525707.1  transcriptional enhancer factor TEF-4 isoform X12

      Conserved Domains (1) summary
      smart00426
      Location:40107
      TEA; TEA domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      52338023..52359872 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322390.1XP_054178365.1  transcriptional enhancer factor TEF-4 isoform X9

    2. XM_054322387.1XP_054178362.1  transcriptional enhancer factor TEF-4 isoform X8

    3. XM_054322386.1XP_054178361.1  transcriptional enhancer factor TEF-4 isoform X7

    4. XM_054322385.1XP_054178360.1  transcriptional enhancer factor TEF-4 isoform X6

    5. XM_054322372.1XP_054178347.1  transcriptional enhancer factor TEF-4 isoform X2

    6. XM_054322383.1XP_054178358.1  transcriptional enhancer factor TEF-4 isoform X5

    7. XM_054322366.1XP_054178341.1  transcriptional enhancer factor TEF-4 isoform X1

    8. XM_054322393.1XP_054178368.1  transcriptional enhancer factor TEF-4 isoform X10

    9. XM_054322391.1XP_054178366.1  transcriptional enhancer factor TEF-4 isoform X9

    10. XM_054322388.1XP_054178363.1  transcriptional enhancer factor TEF-4 isoform X8

    11. XM_054322378.1XP_054178353.1  transcriptional enhancer factor TEF-4 isoform X4

      UniProtKB/Swiss-Prot
      B4DTJ6, M0R1T9, Q15562, Q8NA25, Q96IG3
    12. XM_054322374.1XP_054178349.1  transcriptional enhancer factor TEF-4 isoform X3

    13. XM_054322367.1XP_054178342.1  transcriptional enhancer factor TEF-4 isoform X1

    14. XM_054322382.1XP_054178357.1  transcriptional enhancer factor TEF-4 isoform X4

      UniProtKB/Swiss-Prot
      B4DTJ6, M0R1T9, Q15562, Q8NA25, Q96IG3
    15. XM_054322371.1XP_054178346.1  transcriptional enhancer factor TEF-4 isoform X1

    16. XM_054322381.1XP_054178356.1  transcriptional enhancer factor TEF-4 isoform X4

      UniProtKB/Swiss-Prot
      B4DTJ6, M0R1T9, Q15562, Q8NA25, Q96IG3
    17. XM_054322389.1XP_054178364.1  transcriptional enhancer factor TEF-4 isoform X8

    18. XM_054322377.1XP_054178352.1  transcriptional enhancer factor TEF-4 isoform X3

    19. XM_054322392.1XP_054178367.1  transcriptional enhancer factor TEF-4 isoform X9

    20. XM_054322369.1XP_054178344.1  transcriptional enhancer factor TEF-4 isoform X1

    21. XM_054322375.1XP_054178350.1  transcriptional enhancer factor TEF-4 isoform X3

    22. XM_054322373.1XP_054178348.1  transcriptional enhancer factor TEF-4 isoform X2

    23. XM_054322379.1XP_054178354.1  transcriptional enhancer factor TEF-4 isoform X4

      UniProtKB/Swiss-Prot
      B4DTJ6, M0R1T9, Q15562, Q8NA25, Q96IG3
    24. XM_054322380.1XP_054178355.1  transcriptional enhancer factor TEF-4 isoform X4

      UniProtKB/Swiss-Prot
      B4DTJ6, M0R1T9, Q15562, Q8NA25, Q96IG3
    25. XM_054322376.1XP_054178351.1  transcriptional enhancer factor TEF-4 isoform X3

    26. XM_054322384.1XP_054178359.1  transcriptional enhancer factor TEF-4 isoform X5

    27. XM_054322368.1XP_054178343.1  transcriptional enhancer factor TEF-4 isoform X1

    28. XM_054322370.1XP_054178345.1  transcriptional enhancer factor TEF-4 isoform X1

    29. XM_054322394.1XP_054178369.1  transcriptional enhancer factor TEF-4 isoform X11

    30. XM_054322396.1XP_054178371.1  transcriptional enhancer factor TEF-4 isoform X13

    31. XM_054322395.1XP_054178370.1  transcriptional enhancer factor TEF-4 isoform X12

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