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    LGALS3BP galectin 3 binding protein [ Homo sapiens (human) ]

    Gene ID: 3959, updated on 28-Oct-2024

    Summary

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    Official Symbol
    LGALS3BPprovided by HGNC
    Official Full Name
    galectin 3 binding proteinprovided by HGNC
    Primary source
    HGNC:HGNC:6564
    See related
    Ensembl:ENSG00000108679 MIM:600626; AllianceGenome:HGNC:6564
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    90K; M2BP; gp90; CyCAP; BTBD17B; MAC-2-BP; TANGO10B
    Summary
    The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus (HIV). It appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity. Using fluorescence in situ hybridization the full length 90K cDNA has been localized to chromosome 17q25. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds galectin 1. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in stomach (RPKM 179.8), colon (RPKM 156.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See LGALS3BP in Genome Data Viewer
    Location:
    17q25.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (78971255..78979923, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (79866027..79877550, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (76967337..76976005, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904068 Neighboring gene Sharpr-MPRA regulatory region 3779 Neighboring gene MPRA-validated peak3021 silencer Neighboring gene TIMP metallopeptidase inhibitor 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76869765-76870265 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76874955-76875848 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76875849-76876740 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76877535-76878035 Neighboring gene Sharpr-MPRA regulatory region 5911/8204 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9076 Neighboring gene CEP295 N-terminal like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76898462-76899062 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76911943-76912638 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76912639-76913334 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76914785-76915760 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12914 Neighboring gene Sharpr-MPRA regulatory region 14803 Neighboring gene Sharpr-MPRA regulatory region 6708 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76972258-76972941 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76976039-76977031 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9077 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12915 Neighboring gene calcium activated nucleotidase 1 Neighboring gene C1QTNF1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9078 Neighboring gene C1q and TNF related 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Galectin-3-binding protein is a novel predictor of venous thromboembolism in systemic lupus erythematosus. Peretz ASR, et al. Clin Exp Rheumatol, 2021 Nov-Dec. PMID 33337998
    2. Hepatic stellate cells secreting WFA(+) -M2BP: Its role in biological interactions with Kupffer cells. Bekki Y, et al. J Gastroenterol Hepatol, 2017 Jul. PMID 28008658
    3. Serum Mac-2-binding protein glycosylation isomer predicts esophagogastric varices in cirrhotic patients with chronic hepatitis C virus infection treated with IFN-free direct-acting antiviral agent: M2BPGi levels predict varices in SVR patients. Kikukawa K, et al. Ann Hepatol, 2020 Jul-Aug. PMID 32444247
    4. Wisteria floribunda Agglutinin-Positive Mac-2 Binding Protein but not α-fetoprotein as a Long-Term Hepatocellular Carcinoma Predictor. Osawa L, et al. Int J Mol Sci, 2020 May 21. PMID 32455631, Free PMC Article
    5. Clinical significance of serum Wisteria floribunda agglutinin-positive Mac-2 binding protein in pancreatic ductal adenocarcinoma. Waragai Y, et al. Pancreatology, 2016 Nov-Dec. PMID 27665173

    See all (253) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Aberrant expression of LGALS3BP drives an unfavorable prognosis and more aggressive in HCC via regulating PI3K/AKT signaling.
      Title: Aberrant expression of LGALS3BP drives an unfavorable prognosis and more aggressive in HCC via regulating PI3K/AKT signaling.
    2. Galectin-3-Binding Protein Inhibits Extracellular Heparan 6-O-Endosulfatase Sulf-2.
      Title: Galectin-3-Binding Protein Inhibits Extracellular Heparan 6-O-Endosulfatase Sulf-2.
    3. Potential of Mac-2-binding protein glycan isomer as a new therapeutic target in pancreatic cancer.
      Title: Potential of Mac-2-binding protein glycan isomer as a new therapeutic target in pancreatic cancer.
    4. Diagnostic Value of Serum Galectin-3 Binding Protein Level in Patients with Pulmonary Arterial Hypertension.
      Title: Diagnostic Value of Serum Galectin-3 Binding Protein Level in Patients with Pulmonary Arterial Hypertension.
    5. LGALS3BP is a novel and potential biomarker in clear cell renal cell carcinoma.
      Title: LGALS3BP is a novel and potential biomarker in clear cell renal cell carcinoma.
    6. 90K/LGALS3BP expression is upregulated in COVID-19 but may not restrict SARS-CoV-2 infection.
      Title: 90K/LGALS3BP expression is upregulated in COVID-19 but may not restrict SARS-CoV-2 infection.
    7. Polymeric immunoglobulin receptor and galectin-3-binding protein are raised in biliary atresia: Reveals a proteomic-based study.
      Title: Polymeric immunoglobulin receptor and galectin-3-binding protein are raised in biliary atresia: Reveals a proteomic-based study.
    8. Circular RNA circARHGEF28 inhibited the progression of prostate cancer via the miR-671-5p/LGALS3BP/NF-kappaB axis.
      Title: Circular RNA circARHGEF28 inhibited the progression of prostate cancer via the miR-671-5p/LGALS3BP/NF-κB axis.
    9. Visualizing Galectin-3 Binding Protein Expression with ImmunoPET.
      Title: Visualizing Galectin-3 Binding Protein Expression with ImmunoPET.
    10. Platelet LGALS3BP as a Mediator of Myeloid Inflammation in Systemic Lupus Erythematosus.
      Title: Platelet LGALS3BP as a Mediator of Myeloid Inflammation in Systemic Lupus Erythematosus.
    Submit: New GeneRIF Correction See all GeneRIFs (115)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    HIV-1 replication is inhibited by LGALS3BP (M2BP) overexpression in 293HEK cells PubMed
    Knockdown of 90K/LGALS3BP by siRNA enhances replication and infectivity of HIV-1 in TZM-bl cells and primary macrophages PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env The two central protein-binding domains (residues 127-409) of 90K/LGALS3BP are required for inhibition of gp160 processing and incorporation of the viral gp120/gp41 glycoproteins into progeny virions PubMed
    env The expression of 90K/LGALS3BP downregulates the relative amounts of mature gp120/gp41, whereas it upregulates the relative levels of uncleaved gp160 precursor inhibiting incorporation of the viral gp120/gp41 glycoproteins into progeny virions PubMed
    Envelope surface glycoprotein gp160, precursor env The expression of 90K/LGALS3BP downregulates the relative amounts of mature gp120/gp41, whereas it upregulates the relative levels of uncleaved gp160 precursor inhibiting incorporation of the viral gp120/gp41 glycoproteins into progeny virions PubMed
    env The two central protein-binding domains (residues 127-409) of 90K/LGALS3BP are required for inhibition of gp160 processing and incorporation of the viral gp120/gp41 glycoproteins into progeny virions PubMed
    Envelope transmembrane glycoprotein gp41 env The two central protein-binding domains (residues 127-409) of 90K/LGALS3BP are required for inhibition of gp160 processing and incorporation of the viral gp120/gp41 glycoproteins into progeny virions PubMed
    env The expression of 90K/LGALS3BP downregulates the relative amounts of mature gp120/gp41, whereas it upregulates the relative levels of uncleaved gp160 precursor inhibiting incorporation of the viral gp120/gp41 glycoproteins into progeny virions PubMed
    Pol gag-pol HIV-1 Pol is identified to have a physical interaction with lectin, galactoside-binding, soluble, 3 binding protein (LGALS3BP) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    Pr55(Gag) gag HIV-1 Gag trafficking to the plasma membrane is inhibited by LGALS3BP (M2BP) and the inhibition by LGALS3BP is dependent upon vimentin PubMed
    gag HIV-1 Gag binds to LGALS3BP (M2BP) PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables scavenger receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular defense response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in blood microparticle HDA PubMed 
    colocalizes_with collagen-containing extracellular matrix HDA PubMed 
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region HDA PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in platelet dense granule lumen TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    galectin-3-binding protein
    Names
    L3 antigen
    MAC2BP
    Mac-2-binding protein
    basement membrane autoantigen p105
    lectin galactoside-binding soluble 3-binding protein
    mac-2 BP
    serum protein 90K
    transport and golgi organization 10 homolog B
    tumor-associated antigen 90K
    NP_005558.1
    XP_054172018.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005567.4 → NP_005558.1  galectin-3-binding protein precursor

      See identical proteins and their annotated locations for NP_005558.1

      Status: REVIEWED

      Source sequence(s)
      BC002403, L13210
      Consensus CDS
      CCDS11759.1
      UniProtKB/Swiss-Prot
      A0A0S2Z3Y1, Q08380, Q7M4S0, Q9UCH8, Q9UCH9, Q9UCI0
      UniProtKB/TrEMBL
      B4DVE1
      Related
      ENSP00000262776.2, ENST00000262776.8
      Conserved Domains (3) summary
      smart00202
      Location:24 → 124
      SR; Scavenger receptor Cys-rich
      cd18304
      Location:136 → 247
      BTB_POZ_M2BP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Mac-2-binding protein (MAC2BP/M2BP)
      cd18496
      Location:256 → 329
      BACK_LGALS3BP; BACK (BTB and C-terminal Kelch) domain found in lectin galactoside-binding soluble 3-binding protein (LGALS3BP)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      78971255..78979923 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      79866027..79877550 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054316043.1 → XP_054172018.1  galectin-3-binding protein isoform X1

      UniProtKB/Swiss-Prot
      A0A0S2Z3Y1, Q08380, Q7M4S0, Q9UCH8, Q9UCH9, Q9UCI0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08380.1 GenPept UniProtKB/Swiss-Prot:Q08380

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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