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    METTL21A methyltransferase 21A, HSPA lysine [ Homo sapiens (human) ]

    Gene ID: 151194, updated on 30-Oct-2024

    Summary

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    Official Symbol
    METTL21Aprovided by HGNC
    Official Full Name
    methyltransferase 21A, HSPA lysineprovided by HGNC
    Primary source
    HGNC:HGNC:30476
    See related
    Ensembl:ENSG00000144401 MIM:615257; AllianceGenome:HGNC:30476
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FAM119A; HCA557b; HSPA-KMT
    Summary
    Enables ATPase binding activity; Hsp70 protein binding activity; and protein-lysine N-methyltransferase activity. Involved in peptidyl-lysine methylation. Part of protein-containing complex. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in lymph node (RPKM 1.8), spleen (RPKM 1.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See METTL21A in Genome Data Viewer
    Location:
    2q33.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (207580635..207626053, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (208054650..208100120, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (208445359..208490777, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17035 Neighboring gene uncharacterized LOC105373851 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:208259108-208260307 Neighboring gene NANOG hESC enhancer GRCh37_chr2:208265954-208266524 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17036 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17037 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12275 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17038 Neighboring gene uncharacterized LOC124907970 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17039 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12276 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12277 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17040 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17041 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12279 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12278 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12280 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:208396403-208396904 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:208396905-208397404 Neighboring gene cAMP responsive element binding protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17042 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12281 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:208490584-208491288 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:208491289-208491991 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:208537981-208538753 Neighboring gene long intergenic non-protein coding RNA 1857 Neighboring gene ribosomal protein S29 pseudogene 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Genome-wide association study identifies a potent locus associated with human opioid sensitivity. Nishizawa D, et al. Mol Psychiatry, 2014 Jan. PMID 23183491, Free PMC Article
    2. Saccharomyces cerevisiae Eukaryotic Elongation Factor 1A (eEF1A) Is Methylated at Lys-390 by a METTL21-Like Methyltransferase. Jakobsson ME, et al. PLoS One, 2015. PMID 26115316, Free PMC Article
    3. Lysine methylation of VCP by a member of a novel human protein methyltransferase family. Kernstock S, et al. Nat Commun, 2012. PMID 22948820
    4. Identification and characterization of a novel human methyltransferase modulating Hsp70 protein function through lysine methylation. Jakobsson ME, et al. J Biol Chem, 2013 Sep 27. PMID 23921388, Free PMC Article
    5. Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations. Xie T, et al. Neurobiol Aging, 2014 Jul. PMID 24529757

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. methyltransferase METTL21A is the enzyme responsible for trimethylation of a conserved lysine residue found in several human Hsp70 (HSPA) proteins
      Title: Identification and characterization of a novel human methyltransferase modulating Hsp70 protein function through lysine methylation.
    2. METTL21A trimethylates Lys-561 in Hsp70 and corresponding residues in other isoforms (Hsc70, BiP)
      Title: A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
    EBI GWAS Catalog
    Genome-wide association study identifies a potent locus associated with human opioid sensitivity.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC45373

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables Hsp70 protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables heat shock protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables histone methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-lysine N-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-lysine N-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-lysine N-methyltransferase activity TAS
    Traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidyl-lysine methylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein methylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT involved_in regulation of ATP-dependent activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    part_of protein-containing complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein N-lysine methyltransferase METTL21A
    Names
    HSPA lysine methyltransferase
    family with sequence similarity 119, member A
    heat shock protein 70kDa lysine (K) methyltransferase
    hepatocellular carcinoma-associated antigen 557b
    methyltransferase like 21A
    methyltransferase-like protein 21A

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127395.5 → NP_001120867.1  protein N-lysine methyltransferase METTL21A isoform 1

      See identical proteins and their annotated locations for NP_001120867.1

      Status: VALIDATED

      Source sequence(s)
      AC079767
      Consensus CDS
      CCDS2376.1
      UniProtKB/Swiss-Prot
      Q53RV0, Q8N1Z9, Q8WXB1, Q96GH6
      Related
      ENSP00000415115.1, ENST00000411432.6
      Conserved Domains (1) summary
      pfam10294
      Location:25 → 190
      Methyltransf_16; Lysine methyltransferase

    2. NM_001308021.3 → NP_001294950.1  protein N-lysine methyltransferase METTL21A isoform 2

      See identical proteins and their annotated locations for NP_001294950.1

      Status: VALIDATED

      Source sequence(s)
      AC079767, BC009462, BG198655, CN367990
      Consensus CDS
      CCDS77514.1
      UniProtKB/TrEMBL
      C9JES0
      Related
      ENSP00000416570.1, ENST00000432416.5
      Conserved Domains (1) summary
      cl17173
      Location:25 → 87
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    3. NM_001330130.2 → NP_001317059.1  protein N-lysine methyltransferase METTL21A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC079767, AF455817
      Consensus CDS
      CCDS2376.1
      UniProtKB/Swiss-Prot
      Q53RV0, Q8N1Z9, Q8WXB1, Q96GH6
      Related
      ENSP00000385481.2, ENST00000406927.6
      Conserved Domains (1) summary
      pfam10294
      Location:25 → 190
      Methyltransf_16; Lysine methyltransferase

    4. NM_001330131.2 → NP_001317060.1  protein N-lysine methyltransferase METTL21A isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC009298, AC079767, BC009462
      Consensus CDS
      CCDS82562.1
      UniProtKB/Swiss-Prot
      Q8WXB1
      Related
      ENSP00000389684.1, ENST00000458426.5
      Conserved Domains (1) summary
      cl17173
      Location:25 → 90
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    5. NM_001330132.3 → NP_001317061.1  protein N-lysine methyltransferase METTL21A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC009298, AC079767
      Consensus CDS
      CCDS77514.1
      UniProtKB/TrEMBL
      C9JES0
      Conserved Domains (1) summary
      cl17173
      Location:25 → 87
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    6. NM_001330133.3 → NP_001317062.1  protein N-lysine methyltransferase METTL21A isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC009298, AC079767
      Consensus CDS
      CCDS82562.1
      UniProtKB/Swiss-Prot
      Q8WXB1
      Conserved Domains (1) summary
      cl17173
      Location:25 → 90
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    7. NM_001330134.2 → NP_001317063.1  protein N-lysine methyltransferase METTL21A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC079767
      Consensus CDS
      CCDS2376.1
      UniProtKB/Swiss-Prot
      Q53RV0, Q8N1Z9, Q8WXB1, Q96GH6
      Related
      ENSP00000392062.1, ENST00000442521.1
      Conserved Domains (1) summary
      pfam10294
      Location:25 → 190
      Methyltransf_16; Lysine methyltransferase

    8. NM_001330135.2 → NP_001317064.1  protein N-lysine methyltransferase METTL21A isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC009298, AC079767
      Consensus CDS
      CCDS82562.1
      UniProtKB/Swiss-Prot
      Q8WXB1
      Related
      ENSP00000400730.1, ENST00000425132.5
      Conserved Domains (1) summary
      cl17173
      Location:25 → 90
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    9. NM_001330136.3 → NP_001317065.1  protein N-lysine methyltransferase METTL21A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC009298, AC079767
      Consensus CDS
      CCDS77514.1
      UniProtKB/TrEMBL
      C9JES0
      Conserved Domains (1) summary
      cl17173
      Location:25 → 87
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    10. NM_001330137.2 → NP_001317066.1  protein N-lysine methyltransferase METTL21A isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC079767
      Consensus CDS
      CCDS82563.1
      UniProtKB/TrEMBL
      H7BXH9
      Conserved Domains (1) summary
      pfam10294
      Location:25 → 208
      Methyltransf_16; Lysine methyltransferase

    11. NM_001388427.1 → NP_001375356.1  protein N-lysine methyltransferase METTL21A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC009298, AC079767
      Consensus CDS
      CCDS77514.1
      UniProtKB/TrEMBL
      C9JES0
      Conserved Domains (1) summary
      cl17173
      Location:25 → 87
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    12. NM_001388439.2 → NP_001375368.1  protein N-lysine methyltransferase METTL21A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC009298, AC079767
      Consensus CDS
      CCDS77514.1
      UniProtKB/TrEMBL
      C9JES0
      Conserved Domains (1) summary
      cl17173
      Location:25 → 87
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    13. NM_001393563.1 → NP_001380492.1  protein N-lysine methyltransferase METTL21A isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC009298, AC079767
      Conserved Domains (1) summary
      cl17173
      Location:25 → 86
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    14. NM_001393564.1 → NP_001380493.1  protein N-lysine methyltransferase METTL21A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC009298, AC079767
      Consensus CDS
      CCDS77514.1
      UniProtKB/TrEMBL
      C9JES0
      Conserved Domains (1) summary
      cl17173
      Location:25 → 87
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    15. NM_001393565.1 → NP_001380494.1  protein N-lysine methyltransferase METTL21A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC009298, AC079767
      Consensus CDS
      CCDS77514.1
      UniProtKB/TrEMBL
      C9JES0
      Conserved Domains (1) summary
      cl17173
      Location:25 → 87
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    16. NM_001393566.1 → NP_001380495.1  protein N-lysine methyltransferase METTL21A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC009298, AC079767
      Consensus CDS
      CCDS77514.1
      UniProtKB/TrEMBL
      C9JES0
      Conserved Domains (1) summary
      cl17173
      Location:25 → 87
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    17. NM_001393567.1 → NP_001380496.1  protein N-lysine methyltransferase METTL21A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC009298, AC079767
      Consensus CDS
      CCDS77514.1
      UniProtKB/TrEMBL
      C9JES0
      Conserved Domains (1) summary
      cl17173
      Location:25 → 87
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    18. NM_001393568.1 → NP_001380497.1  protein N-lysine methyltransferase METTL21A isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC009298, AC079767
      Conserved Domains (1) summary
      cl17173
      Location:25 → 86
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    19. NM_001393569.1 → NP_001380498.1  protein N-lysine methyltransferase METTL21A isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC009298, AC079767
      Conserved Domains (1) summary
      cl17173
      Location:25 → 86
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    20. NM_001393570.1 → NP_001380499.1  protein N-lysine methyltransferase METTL21A isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC009298, AC079767
      Conserved Domains (1) summary
      cl17173
      Location:25 → 86
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    21. NM_001393571.1 → NP_001380500.1  protein N-lysine methyltransferase METTL21A isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC009298, AC079767
      Conserved Domains (1) summary
      cl17173
      Location:25 → 92
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    22. NM_001393572.1 → NP_001380501.1  protein N-lysine methyltransferase METTL21A isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC009298, AC079767
      Conserved Domains (1) summary
      cl17173
      Location:25 → 92
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    23. NM_001393573.1 → NP_001380502.1  protein N-lysine methyltransferase METTL21A isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC009298, AC079767
      Consensus CDS
      CCDS82562.1
      Conserved Domains (1) summary
      cl17173
      Location:25 → 90
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    24. NM_001393574.1 → NP_001380503.1  protein N-lysine methyltransferase METTL21A isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC009298, AC079767
      Consensus CDS
      CCDS82562.1
      Conserved Domains (1) summary
      cl17173
      Location:25 → 90
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    25. NM_001393575.1 → NP_001380504.1  protein N-lysine methyltransferase METTL21A isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC009298, AC079767
      Consensus CDS
      CCDS82562.1
      Conserved Domains (1) summary
      cl17173
      Location:25 → 90
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    26. NM_145280.7 → NP_660323.3  protein N-lysine methyltransferase METTL21A isoform 1

      See identical proteins and their annotated locations for NP_660323.3

      Status: VALIDATED

      Source sequence(s)
      AC079767, AK093812, BC033720
      Consensus CDS
      CCDS2376.1
      UniProtKB/Swiss-Prot
      Q53RV0, Q8N1Z9, Q8WXB1, Q96GH6
      Related
      ENSP00000407622.2, ENST00000448007.6
      Conserved Domains (1) summary
      pfam10294
      Location:25 → 190
      Methyltransf_16; Lysine methyltransferase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      207580635..207626053 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047443497.1 → XP_047299453.1  protein N-lysine methyltransferase METTL21A isoform X7

      UniProtKB/TrEMBL
      C9JES0

    2. XM_011510728.4 → XP_011509030.1  protein N-lysine methyltransferase METTL21A isoform X5

      See identical proteins and their annotated locations for XP_011509030.1

      Conserved Domains (1) summary
      cl17173
      Location:50 → 112
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    3. XM_047443496.1 → XP_047299452.1  protein N-lysine methyltransferase METTL21A isoform X6

    4. XM_006712327.4 → XP_006712390.1  protein N-lysine methyltransferase METTL21A isoform X3

      See identical proteins and their annotated locations for XP_006712390.1

      UniProtKB/TrEMBL
      H7BXH9
      Conserved Domains (1) summary
      pfam10294
      Location:25 → 208
      Methyltransf_16; Lysine methyltransferase

    5. XM_024452722.2 → XP_024308490.1  protein N-lysine methyltransferase METTL21A isoform X4

      UniProtKB/Swiss-Prot
      Q53RV0, Q8N1Z9, Q8WXB1, Q96GH6
      Conserved Domains (1) summary
      pfam10294
      Location:25 → 190
      Methyltransf_16; Lysine methyltransferase

    6. XM_005246337.5 → XP_005246394.1  protein N-lysine methyltransferase METTL21A isoform X3

      See identical proteins and their annotated locations for XP_005246394.1

      UniProtKB/TrEMBL
      H7BXH9
      Related
      ENSP00000272839.3, ENST00000272839.7
      Conserved Domains (1) summary
      pfam10294
      Location:25 → 208
      Methyltransf_16; Lysine methyltransferase

    7. XM_005246336.4 → XP_005246393.1  protein N-lysine methyltransferase METTL21A isoform X3

      See identical proteins and their annotated locations for XP_005246393.1

      UniProtKB/TrEMBL
      H7BXH9
      Conserved Domains (1) summary
      pfam10294
      Location:25 → 208
      Methyltransf_16; Lysine methyltransferase

    8. XM_024452721.2 → XP_024308489.1  protein N-lysine methyltransferase METTL21A isoform X3

      UniProtKB/TrEMBL
      H7BXH9
      Conserved Domains (1) summary
      pfam10294
      Location:25 → 208
      Methyltransf_16; Lysine methyltransferase

    9. XM_011510725.3 → XP_011509027.1  protein N-lysine methyltransferase METTL21A isoform X2

      Conserved Domains (1) summary
      pfam10294
      Location:50 → 215
      Methyltransf_16; Lysine methyltransferase

    10. XM_011510724.3 → XP_011509026.1  protein N-lysine methyltransferase METTL21A isoform X1

      Conserved Domains (1) summary
      pfam10294
      Location:50 → 233
      Methyltransf_16; Lysine methyltransferase

    11. XM_047443499.1 → XP_047299455.1  protein N-lysine methyltransferase METTL21A isoform X9

    12. XM_047443498.1 → XP_047299454.1  protein N-lysine methyltransferase METTL21A isoform X8

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      208054650..208100120 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054340752.1 → XP_054196727.1  protein N-lysine methyltransferase METTL21A isoform X7

      UniProtKB/TrEMBL
      C9JES0

    2. XM_054340750.1 → XP_054196725.1  protein N-lysine methyltransferase METTL21A isoform X5

    3. XM_054340751.1 → XP_054196726.1  protein N-lysine methyltransferase METTL21A isoform X6

    4. XM_054340755.1 → XP_054196730.1  protein N-lysine methyltransferase METTL21A isoform X3

      UniProtKB/TrEMBL
      H7BXH9

    5. XM_054340749.1 → XP_054196724.1  protein N-lysine methyltransferase METTL21A isoform X4

      UniProtKB/Swiss-Prot
      Q53RV0, Q8N1Z9, Q8WXB1, Q96GH6

    6. XM_054340747.1 → XP_054196722.1  protein N-lysine methyltransferase METTL21A isoform X3

      UniProtKB/TrEMBL
      H7BXH9

    7. XM_054340756.1 → XP_054196731.1  protein N-lysine methyltransferase METTL21A isoform X3

      UniProtKB/TrEMBL
      H7BXH9

    8. XM_054340748.1 → XP_054196723.1  protein N-lysine methyltransferase METTL21A isoform X3

      UniProtKB/TrEMBL
      H7BXH9

    9. XM_054340746.1 → XP_054196721.1  protein N-lysine methyltransferase METTL21A isoform X2

    10. XM_054340745.1 → XP_054196720.1  protein N-lysine methyltransferase METTL21A isoform X1

    11. XM_054340754.1 → XP_054196729.1  protein N-lysine methyltransferase METTL21A isoform X9

    12. XM_054340753.1 → XP_054196728.1  protein N-lysine methyltransferase METTL21A isoform X8

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001388425.1: Suppressed sequence

      Description
      NM_001388425.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8WXB1.2 GenPept UniProtKB/Swiss-Prot:Q8WXB1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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