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    ZC3HAV1 zinc finger CCCH-type containing, antiviral 1 [ Homo sapiens (human) ]

    Gene ID: 56829, updated on 28-Oct-2024

    Summary

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    Official Symbol
    ZC3HAV1provided by HGNC
    Official Full Name
    zinc finger CCCH-type containing, antiviral 1provided by HGNC
    Primary source
    HGNC:HGNC:23721
    See related
    Ensembl:ENSG00000105939 MIM:607312; AllianceGenome:HGNC:23721
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZAP; ZC3H2; ARTD13; PARP13; FLB6421; ZC3HDC2
    Summary
    This gene encodes a CCCH-type zinc finger protein. This antiviral protein inhibits viral replication by recruiting cellular RNA degradation machineries to degrade viral mRNAs. The encoded protein plays an important role in the innate immune response against multiple DNA and RNA viruses, including Ebola virus, HIV and SARS-CoV-2 (which causes COVID-19). [provided by RefSeq, Sep 2021]
    Annotation information
    Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
    Expression
    Ubiquitous expression in bone marrow (RPKM 17.0), lymph node (RPKM 9.0) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZC3HAV1 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (139043515..139109720, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (140356423..140423001, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (138728261..138794466, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ZC3HAV1 like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:138720195-138721114 Neighboring gene uncharacterized LOC107986852 Neighboring gene microRNA 10399 Neighboring gene ribosomal protein L17 pseudogene 28 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr7:138786521-138787092 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26746 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:138794119-138794622 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26749 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26750 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26751 Neighboring gene Sharpr-MPRA regulatory region 4033 Neighboring gene Sharpr-MPRA regulatory region 8039 Neighboring gene intraflagellar transport 56 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:138859395-138860231 Neighboring gene NANOG hESC enhancer GRCh37_chr7:138867531-138868130 Neighboring gene Sharpr-MPRA regulatory region 12471 Neighboring gene MSL3 pseudogene 2 Neighboring gene FCF1 pseudogene 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. RNA-binding protein isoforms ZAP-S and ZAP-L have distinct antiviral and immune resolution functions. Schwerk J, et al. Nat Immunol, 2019 Dec. PMID 31740798, Free PMC Article
    2. The alternate triad motif of the poly(ADP-ribose) polymerase-like domain of the human zinc finger antiviral protein is essential for its antiviral activity. Gläsker S, et al. J Gen Virol, 2014 Apr. PMID 24457973
    3. PARP13 regulates cellular mRNA post-transcriptionally and functions as a pro-apoptotic factor by destabilizing TRAILR4 transcript. Todorova T, et al. Nat Commun, 2014 Nov 10. PMID 25382312, Free PMC Article
    4. Poly(ADP-ribose) polymerase-13 and RNA regulation in immunity and cancer. Todorova T, et al. Trends Mol Med, 2015 Jun. PMID 25851173, Free PMC Article
    5. Inhibition of Japanese encephalitis virus infection by the host zinc-finger antiviral protein. Chiu HP, et al. PLoS Pathog, 2018 Jul. PMID 30016363, Free PMC Article

    See all (275) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Endogenous ZAP affects Zika virus RNA interactome.
      Title: Endogenous ZAP affects Zika virus RNA interactome.
    2. Association of ZC3HAV1 single nucleotide polymorphisms with the susceptibility of Vogt-Koyanagi-Harada Disease.
      Title: Association of ZC3HAV1 single nucleotide polymorphisms with the susceptibility of Vogt-Koyanagi-Harada Disease.
    3. Expression of Zinc-Finger Antiviral Protein in hCMEC/D3 Human Cerebral Microvascular Endothelial Cells: Effect of a Toll-Like Receptor 3 Agonist.
      Title: Expression of Zinc-Finger Antiviral Protein in hCMEC/D3 Human Cerebral Microvascular Endothelial Cells: Effect of a Toll-Like Receptor 3 Agonist.
    4. ZAP isoforms regulate unfolded protein response and epithelial- mesenchymal transition.
      Title: ZAP isoforms regulate unfolded protein response and epithelial- mesenchymal transition.
    5. The low abundance of CpG in the SARS-CoV-2 genome is not an evolutionarily signature of ZAP.
      Title: The low abundance of CpG in the SARS-CoV-2 genome is not an evolutionarily signature of ZAP.
    6. Chemical genetics and proteome-wide site mapping reveal cysteine MARylation by PARP-7 on immune-relevant protein targets.
      Title: Chemical genetics and proteome-wide site mapping reveal cysteine MARylation by PARP-7 on immune-relevant protein targets.
    7. ZC3HAV1 promotes the proliferation and metastasis via regulating KRAS in pancreatic cancer.
      Title: ZC3HAV1 promotes the proliferation and metastasis via regulating KRAS in pancreatic cancer.
    8. The Zinc Finger Antiviral Protein ZAP Restricts Human Cytomegalovirus and Selectively Binds and Destabilizes Viral UL4/UL5 Transcripts.
      Title: The Zinc Finger Antiviral Protein ZAP Restricts Human Cytomegalovirus and Selectively Binds and Destabilizes Viral UL4/UL5 Transcripts.
    9. Association of Zinc Finger Antiviral Protein Binding to Viral Genomic RNA with Attenuation of Replication of Echovirus 7.
      Title: Association of Zinc Finger Antiviral Protein Binding to Viral Genomic RNA with Attenuation of Replication of Echovirus 7.
    10. The Interaction of Human and Epstein-Barr Virus miRNAs with Multiple Sclerosis Risk Loci.
      Title: The Interaction of Human and Epstein-Barr Virus miRNAs with Multiple Sclerosis Risk Loci.
    Submit: New GeneRIF Correction See all GeneRIFs (44)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of ZC3HAV1 PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Cellular biotinylated zinc finger CCCH-type, antiviral 1 (ZC3HAV1) protein is incorporated into HIV-1 Gag virus-like particles PubMed
    gag Interaction of HIV-1 Gag with zinc finger CCCH-type, antiviral 1 (ZC3HAV1) is identified in a series of six affinity purification/mass spectrometry screens PubMed
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human zinc finger CCCH-type, antiviral 1 (ZC3HAV1) at amino acid residues 260-261 by the HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ13288, MGC48898, DKFZp686F2052, DKFZp686H1869, DKFZp686O19171

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    NOT enables NAD+ binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT enables NAD+-protein ADP-ribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables NAD+-protein poly-ADP-ribosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables RNA binding HDA PubMed 
    enables cadherin binding HDA PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of viral genome replication IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of RIG-I signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of interferon-alpha production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of interferon-beta production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of mRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of mRNA catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of type I interferon production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT involved_in protein poly-ADP-ribosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to virus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to virus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in late endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger CCCH-type antiviral protein 1
    Names
    ADP-ribosyltransferase diphtheria toxin-like 13
    inactive Poly [ADP-ribose] polymerase 13
    zinc finger CCCH domain-containing protein 2
    zinc finger CCCH-type, antiviral 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029457.1 RefSeqGene

      Range
      5000..71205
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001363491.2 → NP_001350420.1  zinc finger CCCH-type antiviral protein 1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC018644, AC083868, AI133088, BC040956, BU634030, BX571742, BX647974
      Consensus CDS
      CCDS94214.1
      UniProtKB/TrEMBL
      A8K9U6, C9J6P4
      Related
      ENSP00000418385.1, ENST00000464606.5
      Conserved Domains (2) summary
      smart00678
      Location:729 → 811
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd01439
      Location:906 → 1015
      TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...

    2. NM_020119.4 → NP_064504.2  zinc finger CCCH-type antiviral protein 1 isoform 1

      See identical proteins and their annotated locations for NP_064504.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant encodes isoform 1.
      Source sequence(s)
      AC018644, AC083868, BC040956, BX571742, BX647974
      Consensus CDS
      CCDS5851.1
      UniProtKB/Swiss-Prot
      A4D1R2, A4D1S4, Q7Z2W4, Q8IW57, Q8TAJ3, Q96N79, Q9H8R9, Q9P0Y7
      UniProtKB/TrEMBL
      A8K9U6
      Related
      ENSP00000242351.5, ENST00000242351.10
      Conserved Domains (3) summary
      smart00678
      Location:607 → 689
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd01439
      Location:784 → 893
      TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
      pfam00644
      Location:727 → 893
      PARP; Poly(ADP-ribose) polymerase catalytic domain

    3. NM_024625.4 → NP_078901.3  zinc finger CCCH-type antiviral protein 1 isoform 2

      See identical proteins and their annotated locations for NP_078901.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region and lacks several downstream exons, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC018644
      Consensus CDS
      CCDS55171.1
      UniProtKB/TrEMBL
      A0A514C937
      Related
      ENSP00000419855.1, ENST00000471652.1
      Conserved Domains (1) summary
      smart00678
      Location:607 → 689
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      139043515..139109720 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      140356423..140423001 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7Z2W4.3 GenPept UniProtKB/Swiss-Prot:Q7Z2W4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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