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    TRIM3 tripartite motif containing 3 [ Homo sapiens (human) ]

    Gene ID: 10612, updated on 2-Nov-2024

    Summary

    Official Symbol
    TRIM3provided by HGNC
    Official Full Name
    tripartite motif containing 3provided by HGNC
    Primary source
    HGNC:HGNC:10064
    See related
    Ensembl:ENSG00000110171 MIM:605493; AllianceGenome:HGNC:10064
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BERP; HAC1; RNF22; RNF97
    Summary
    The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also called the 'RING-B-box-coiled-coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic filaments. It is similar to a rat protein which is a specific partner for the tail domain of myosin V, a class of myosins which are involved in the targeted transport of organelles. The rat protein can also interact with alpha-actinin-4. Thus it is suggested that this human protein may play a role in myosin V-mediated cargo transport. Alternatively spliced transcript variants encoding the same isoform have been identified. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in duodenum (RPKM 6.6), small intestine (RPKM 6.1) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TRIM3 in Genome Data Viewer
    Location:
    11p15.4
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (6448613..6474459, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (6507075..6532930, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (6469843..6495689, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene amyloid beta precursor protein binding family B member 1 Neighboring gene Sharpr-MPRA regulatory region 8482 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3100 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3101 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4340 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3102 Neighboring gene hemopexin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4341 Neighboring gene Sharpr-MPRA regulatory region 6512 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:6493832-6494771 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:6494772-6495710 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:6502154-6503353 Neighboring gene ARF interacting protein 2 Neighboring gene translocase of inner mitochondrial membrane 10B

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ16135

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables translation repressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    tripartite motif-containing protein 3
    Names
    RING finger protein 97
    brain expressed ring finger
    brain-expressed RING finger protein
    ring finger protein 22
    tripartite motif protein TRIM3
    NP_001234935.1
    NP_001234936.1
    NP_006449.2
    NP_150594.2
    XP_016872587.1
    XP_024304096.1
    XP_047282213.1
    XP_047282214.1
    XP_047282215.1
    XP_047282217.1
    XP_047282218.1
    XP_054223451.1
    XP_054223452.1
    XP_054223453.1
    XP_054223454.1
    XP_054223455.1
    XP_054223456.1
    XP_054223457.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001248006.2NP_001234935.1  tripartite motif-containing protein 3 isoform 1

      See identical proteins and their annotated locations for NP_001234935.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains a different 5' UTR, compared to variant 1. Variants 1, 2, and 4 encode the same protein (isoform 1).
      Source sequence(s)
      AC084337
      Consensus CDS
      CCDS7764.1
      UniProtKB/Swiss-Prot
      B7Z5E6, F5H2Q8, O75382, Q4V9L4, Q9C038, Q9C039
      UniProtKB/TrEMBL
      B7Z5Y8
      Related
      ENSP00000433102.1, ENST00000525074.5
      Conserved Domains (5) summary
      smart00502
      Location:158284
      BBC; B-Box C-terminal domain
      smart00336
      Location:110151
      BBOX; B-Box-type zinc finger
      smart00557
      Location:322419
      IG_FLMN; Filamin-type immunoglobulin domains
      cd14960
      Location:471744
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd16768
      Location:1963
      RING-HC_TRIM3; RING finger, HC subclass, found in tripartite motif-containing protein 3 (TRIM3)
    2. NM_001248007.2NP_001234936.1  tripartite motif-containing protein 3 isoform 2

      See identical proteins and their annotated locations for NP_001234936.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks several exons, which results in translation initiation at a downstream start codon, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AK291396, AK298843, AK299586, AL122053, BC096827
      Consensus CDS
      CCDS58115.1
      UniProtKB/Swiss-Prot
      O75382
      UniProtKB/TrEMBL
      B7Z5Y8
      Related
      ENSP00000445460.1, ENST00000536344.5
      Conserved Domains (4) summary
      smart00502
      Location:39165
      BBC; B-Box C-terminal domain
      smart00557
      Location:203300
      IG_FLMN; Filamin-type immunoglobulin domains
      cd14960
      Location:352625
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cl00034
      Location:234
      Bbox_SF; B-box-type zinc finger superfamily
    3. NM_006458.4NP_006449.2  tripartite motif-containing protein 3 isoform 1

      See identical proteins and their annotated locations for NP_006449.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 4 encode the same protein (isoform 1).
      Source sequence(s)
      AK291396, AK299586, AL122053, BC096827, BI916995
      Consensus CDS
      CCDS7764.1
      UniProtKB/Swiss-Prot
      B7Z5E6, F5H2Q8, O75382, Q4V9L4, Q9C038, Q9C039
      UniProtKB/TrEMBL
      B7Z5Y8
      Related
      ENSP00000352508.3, ENST00000359518.7
      Conserved Domains (5) summary
      smart00502
      Location:158284
      BBC; B-Box C-terminal domain
      smart00336
      Location:110151
      BBOX; B-Box-type zinc finger
      smart00557
      Location:322419
      IG_FLMN; Filamin-type immunoglobulin domains
      cd14960
      Location:471744
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd16768
      Location:1963
      RING-HC_TRIM3; RING finger, HC subclass, found in tripartite motif-containing protein 3 (TRIM3)
    4. NM_033278.4NP_150594.2  tripartite motif-containing protein 3 isoform 1

      See identical proteins and their annotated locations for NP_150594.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 4 encode the same protein (isoform 1).
      Source sequence(s)
      AL122053, BC096827, BM758857, DA089323, DA347370, DB344600
      Consensus CDS
      CCDS7764.1
      UniProtKB/Swiss-Prot
      B7Z5E6, F5H2Q8, O75382, Q4V9L4, Q9C038, Q9C039
      UniProtKB/TrEMBL
      B7Z5Y8
      Related
      ENSP00000340797.3, ENST00000345851.8
      Conserved Domains (5) summary
      smart00502
      Location:158284
      BBC; B-Box C-terminal domain
      smart00336
      Location:110151
      BBOX; B-Box-type zinc finger
      smart00557
      Location:322419
      IG_FLMN; Filamin-type immunoglobulin domains
      cd14960
      Location:471744
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd16768
      Location:1963
      RING-HC_TRIM3; RING finger, HC subclass, found in tripartite motif-containing protein 3 (TRIM3)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      6448613..6474459 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047426261.1XP_047282217.1  tripartite motif-containing protein 3 isoform X4

    2. XM_024448328.2XP_024304096.1  tripartite motif-containing protein 3 isoform X3

      UniProtKB/Swiss-Prot
      B7Z5E6, F5H2Q8, O75382, Q4V9L4, Q9C038, Q9C039
      UniProtKB/TrEMBL
      B7Z5Y8
      Conserved Domains (5) summary
      smart00502
      Location:158284
      BBC; B-Box C-terminal domain
      smart00336
      Location:110151
      BBOX; B-Box-type zinc finger
      smart00557
      Location:322419
      IG_FLMN; Filamin-type immunoglobulin domains
      cd14960
      Location:471744
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd16768
      Location:1963
      RING-HC_TRIM3; RING finger, HC subclass, found in tripartite motif-containing protein 3 (TRIM3)
    3. XM_017017098.3XP_016872587.1  tripartite motif-containing protein 3 isoform X3

      UniProtKB/Swiss-Prot
      B7Z5E6, F5H2Q8, O75382, Q4V9L4, Q9C038, Q9C039
      UniProtKB/TrEMBL
      B7Z5Y8
      Conserved Domains (5) summary
      smart00502
      Location:158284
      BBC; B-Box C-terminal domain
      smart00336
      Location:110151
      BBOX; B-Box-type zinc finger
      smart00557
      Location:322419
      IG_FLMN; Filamin-type immunoglobulin domains
      cd14960
      Location:471744
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd16768
      Location:1963
      RING-HC_TRIM3; RING finger, HC subclass, found in tripartite motif-containing protein 3 (TRIM3)
    4. XM_047426258.1XP_047282214.1  tripartite motif-containing protein 3 isoform X2

    5. XM_047426257.1XP_047282213.1  tripartite motif-containing protein 3 isoform X1

    6. XM_047426259.1XP_047282215.1  tripartite motif-containing protein 3 isoform X3

      UniProtKB/Swiss-Prot
      B7Z5E6, F5H2Q8, O75382, Q4V9L4, Q9C038, Q9C039
    7. XM_047426262.1XP_047282218.1  tripartite motif-containing protein 3 isoform X5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      6507075..6532930 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054367481.1XP_054223456.1  tripartite motif-containing protein 3 isoform X4

    2. XM_054367478.1XP_054223453.1  tripartite motif-containing protein 3 isoform X3

      UniProtKB/Swiss-Prot
      B7Z5E6, F5H2Q8, O75382, Q4V9L4, Q9C038, Q9C039
    3. XM_054367479.1XP_054223454.1  tripartite motif-containing protein 3 isoform X3

      UniProtKB/Swiss-Prot
      B7Z5E6, F5H2Q8, O75382, Q4V9L4, Q9C038, Q9C039
    4. XM_054367477.1XP_054223452.1  tripartite motif-containing protein 3 isoform X2

    5. XM_054367476.1XP_054223451.1  tripartite motif-containing protein 3 isoform X1

    6. XM_054367480.1XP_054223455.1  tripartite motif-containing protein 3 isoform X3

      UniProtKB/Swiss-Prot
      B7Z5E6, F5H2Q8, O75382, Q4V9L4, Q9C038, Q9C039
    7. XM_054367482.1XP_054223457.1  tripartite motif-containing protein 3 isoform X5

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_033279.1: Suppressed sequence

      Description
      NM_033279.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.