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    dnajb6b DnaJ heat shock protein family (Hsp40) member B6b [ Danio rerio (zebrafish) ]

    Gene ID: 393275, updated on 28-Oct-2024

    Summary

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    Official Symbol
    dnajb6bprovided by ZNC
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member B6bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1122
    See related
    Ensembl:ENSDARG00000020953 AllianceGenome:ZFIN:ZDB-GENE-040426-1122
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    dnajb6; zgc:56709
    Summary
    Predicted to enable protein folding chaperone; protein-folding chaperone binding activity; and unfolded protein binding activity. Acts upstream of or within several processes, including myofibril assembly; negative regulation of response to endoplasmic reticulum stress; and skeletal muscle organ development. Located in nuclear envelope. Is expressed in Purkinje cell; heart; lens; and solid lens vesicle. Human ortholog(s) of this gene implicated in autosomal dominant limb-girdle muscular dystrophy type 1. Orthologous to several human genes including DNAJB6 (DnaJ heat shock protein family (Hsp40) member B6); DNAJB7 (DnaJ heat shock protein family (Hsp40) member B7); and DNAJB8 (DnaJ heat shock protein family (Hsp40) member B8). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See dnajb6b in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (40536930..40578782, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (40265911..40307806, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase receptor type N2 Neighboring gene uncharacterized LOC137490295 Neighboring gene microRNA 153a Neighboring gene ubiquitin protein ligase E3C Neighboring gene motor neuron and pancreas homeobox 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial abnormalities contribute to muscle weakness in a Dnajb6 deficient zebrafish model. McKaige EA, et al. Hum Mol Genet, 2024 Jul 6. PMID 38621658, Free PMC Article
    2. A Doxorubicin-induced Cardiomyopathy Model in Adult Zebrafish. Ma X, et al. J Vis Exp, 2018 Jun 7. PMID 29939187, Free PMC Article
    3. A novel mutation in DNAJB6, p.(Phe91Leu), in childhood-onset LGMD1D with a severe phenotype. Nam TS, et al. Neuromuscul Disord, 2015 Nov. PMID 26371419
    4. Lysyl hydroxylase 3 is required for normal lens capsule formation and maintenance of lens epithelium integrity and fate. Taler K, et al. Dev Biol, 2020 Feb 15. PMID 31669351
    5. Mutations affecting the cytoplasmic functions of the co-chaperone DNAJB6 cause limb-girdle muscular dystrophy. Sarparanta J, et al. Nat Genet, 2012 Feb 26. PMID 22366786, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mitochondrial abnormalities contribute to muscle weakness in a Dnajb6 deficient zebrafish model.
      Title: Mitochondrial abnormalities contribute to muscle weakness in a Dnajb6 deficient zebrafish model.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Clone Names

    • MGC56709

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables Hsp70 protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein folding chaperone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cardiac ventricle development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in chaperone-mediated protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within chaperone-mediated protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within muscle attachment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within myofibril assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of response to endoplasmic reticulum stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within skeletal muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    dnaJ homolog subfamily B member 6b
    Names
    DnaJ (Hsp40) homolog, subfamily B, member 6
    DnaJ (Hsp40) homolog, subfamily B, member 6b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200305.1 → NP_956599.1  dnaJ homolog subfamily B member 6b

      See identical proteins and their annotated locations for NP_956599.1

      Status: PROVISIONAL

      Source sequence(s)
      BC049536
      UniProtKB/TrEMBL
      Q7ZW83
      Related
      ENSDARP00000010641.6, ENSDART00000010035.7
      Conserved Domains (1) summary
      pfam00226
      Location:4 → 67
      DnaJ; DnaJ domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      40536930..40578782 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021477435.2 → XP_021333110.1  dnaJ homolog subfamily B member 6b isoform X2

      UniProtKB/TrEMBL
      A0A8M9QGQ3
      Conserved Domains (1) summary
      cl28246
      Location:1 → 133
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

    2. XM_009303366.3 → XP_009301641.1  dnaJ homolog subfamily B member 6b isoform X1

      See identical proteins and their annotated locations for XP_009301641.1

      UniProtKB/TrEMBL
      A0A1D5NSC8, A0A8M3B1D6
      Related
      ENSDARP00000142741.1, ENSDART00000173926.2
      Conserved Domains (1) summary
      pfam00226
      Location:4 → 67
      DnaJ; DnaJ domain

    3. XM_009303365.4 → XP_009301640.1  dnaJ homolog subfamily B member 6b isoform X1

      See identical proteins and their annotated locations for XP_009301640.1

      UniProtKB/TrEMBL
      A0A1D5NSC8, A0A8M3B1D6
      Conserved Domains (1) summary
      pfam00226
      Location:4 → 67
      DnaJ; DnaJ domain

    4. XM_068222194.1 → XP_068078295.1  dnaJ homolog subfamily B member 6b isoform X3

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394715.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      35311..53903 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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