sncgb synuclein, gamma b (breast cancer-specific protein 1) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: sncgbprovided by ZNC
Official Full Name: synuclein, gamma b (breast cancer-specific protein 1)provided by ZNC
Primary source: ZFIN:ZDB-GENE-050522-235
See related: Ensembl:ENSDARG00000109715 AllianceGenome:ZFIN:ZDB-GENE-050522-235
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: sncg; zgc:112131
Summary: Predicted to enable cuprous ion binding activity. Acts upstream of or within dopaminergic neuron differentiation and larval locomotory behavior. Predicted to be active in axon terminus; cytoplasm; and neuronal cell body. Is expressed in basal plate midbrain region; gill; nervous system; testis; and trigeminal placode. Human ortholog(s) of this gene implicated in Lewy body dementia. Orthologous to human SNCG (synuclein gamma). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 12

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (25894494..25916530, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (25803179..25825170, complement)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

these results reveal that coordination of ZNF219L with Sox9a is involved in the regulation of notochord-specific expression of sncgb.
Title: Zinc finger protein 219-like (ZNF219L) and Sox9a regulate synuclein-γ2 (sncgb) expression in the developing notochord of zebrafish.
Data show the sequences of zebrafish synucleins are very similar to those of the human proteins. Whole-mount in situ hybridization show that sncgb was expressed exclusively in the notochord.
Title: Discovery and characterization of three novel synuclein genes in zebrafish.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cuprous ion binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within dopaminergic neuron differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within larval locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synapse organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle endocytosis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in axon terminus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: synuclein, gamma b (breast cancer-specific protein 1)

Names: Sncg1; gamma1a-synuclein; sncga; synuclein, gamma (breast cancer-specific protein 1); zSyn-γ1; zSynA

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001020652.1 → NP_001018488.1 synuclein, gamma b (breast cancer-specific protein 1)

See identical proteins and their annotated locations for NP_001018488.1

Status: PROVISIONAL

Source sequence(s)

BC095672

UniProtKB/TrEMBL

Q502J6

Related

ENSDARP00000149780.1, ENSDART00000186386.1

Conserved Domains (1) summary

pfam01387
Location:1 → 100

Synuclein; Synuclein

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007123.7 Reference GRCz11 Primary Assembly

Range

25894494..25916530 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021480112.2 → XP_021335787.1 synuclein, gamma b (breast cancer-specific protein 1) isoform X1

UniProtKB/TrEMBL

A0A8M9PWC8

Conserved Domains (1) summary

pfam01387
Location:1 → 100

Synuclein