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    ncapg2 non-SMC condensin II complex, subunit G2 [ Danio rerio (zebrafish) ]

    Gene ID: 100037337, updated on 28-Oct-2024

    Summary

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    Official Symbol
    ncapg2provided by ZNC
    Official Full Name
    non-SMC condensin II complex, subunit G2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070410-100
    See related
    Ensembl:ENSDARG00000060023 AllianceGenome:ZFIN:ZDB-GENE-070410-100
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    CAP-G2; id:ibd2775; zgc:162881
    Summary
    Predicted to be involved in mitotic sister chromatid segregation. Predicted to act upstream of or within cell division and chromosome condensation. Predicted to be part of condensin complex. Predicted to be active in nucleus. Is expressed in brain and spinal cord. Orthologous to human NCAPG2 (non-SMC condensin II complex subunit G2). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ncapg2 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (40205410..40227607)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (39934377..39956586)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene dynein 2 intermediate chain 1 Neighboring gene extended synaptotagmin-like protein 2b Neighboring gene protein tyrosine phosphatase receptor type N2 Neighboring gene uncharacterized LOC137490295 Neighboring gene microRNA 153a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Mutations in NCAPG2 Cause a Severe Neurodevelopmental Syndrome that Expands the Phenotypic Spectrum of Condensinopathies. Khan TN, et al. Am J Hum Genet, 2019 Jan 3. PMID 30609410, Free PMC Article
    2. Dhx38 is required for the maintenance and differentiation of erythro-myeloid progenitors and hematopoietic stem cells by alternative splicing. Tu J, et al. Development, 2022 Sep 1. PMID 35929537
    3. A gene expression screen in zebrafish embryogenesis. Kudoh T, et al. Genome Res, 2001 Dec. PMID 11731487
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chromosome condensation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic sister chromatid segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of condensin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    condensin-2 complex subunit G2
    Names
    chromosome-associated protein G2
    leucine zipper protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001089492.3 → NP_001082961.3  condensin-2 complex subunit G2

      See identical proteins and their annotated locations for NP_001082961.3

      Status: VALIDATED

      Source sequence(s)
      BX248235, BX324185, CU467647
      UniProtKB/Swiss-Prot
      E7FH61, F8W2J6
      Related
      ENSDARP00000124705.3, ENSDART00000148390.4
      Conserved Domains (2) summary
      sd00044
      Location:419 → 450
      HEAT; HEAT repeat [structural motif]
      pfam12422
      Location:213 → 361
      Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      40205410..40227607
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005166425.4 → XP_005166482.2  condensin-2 complex subunit G2 isoform X1

      See identical proteins and their annotated locations for XP_005166482.2

      UniProtKB/Swiss-Prot
      E7FH61, F8W2J6
      Conserved Domains (2) summary
      sd00044
      Location:419 → 450
      HEAT; HEAT repeat [structural motif]
      pfam12422
      Location:213 → 361
      Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394703.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      869..13057
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E7FH61.2 GenPept UniProtKB/Swiss-Prot:E7FH61

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