cd248a CD248 molecule, endosialin a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cd248aprovided by ZNC
Official Full Name: CD248 molecule, endosialin aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-2084
See related: Ensembl:ENSDARG00000103713 AllianceGenome:ZFIN:ZDB-GENE-030131-2084
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fb96b12; wu:fb96b12; zgc:162651
Summary: Predicted to enable extracellular matrix binding activity and extracellular matrix protein binding activity. Predicted to be involved in cell migration. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in external side of plasma membrane. Orthologous to human CD248 (CD248 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 7

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (18364190..18367273)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (18111923..18115006)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cd248a and Cd248b in zebrafish participate in innate immune responses.
Title: Cd248a and Cd248b in zebrafish participate in innate immune responses.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables extracellular matrix binding	IBA Inferred from Biological aspect of Ancestor more info
enables extracellular matrix protein binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in animal organ development	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: CD248 molecule, endosialin a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001099228.3 → NP_001092698.3 CD248 molecule, endosialin a precursor

Status: VALIDATED

Source sequence(s)

BX323024

UniProtKB/TrEMBL

A0A0R4IKQ6, A0A8M1NDU1

Related

ENSDARP00000136522.1, ENSDART00000171606.3

Conserved Domains (4) summary

cd03600
Location:32 → 176

CLECT_thrombomodulin_like; C-type lectin-like domain (CTLD) of the type found in human thrombomodulin(TM), Endosialin, C14orf27, and C1qR

pfam12662
Location:309 → 332

cEGF; Complement Clr-like EGF-like

pfam14670
Location:253 → 288

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl00057
Location:327 → 363

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...