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    ctnna2 catenin (cadherin-associated protein), alpha 2 [ Danio rerio (zebrafish) ]

    Gene ID: 567500, updated on 28-Oct-2024

    Summary

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    Official Symbol
    ctnna2provided by ZNC
    Official Full Name
    catenin (cadherin-associated protein), alpha 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060815-3
    See related
    Ensembl:ENSDARG00000024785 AllianceGenome:ZFIN:ZDB-GENE-060815-3
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    catna2l; bZ1H10.1; im:5410539; si:rp71-1h10.1
    Summary
    Predicted to enable actin filament binding activity; cadherin binding activity; and structural molecule activity. Predicted to be involved in several processes, including brain morphogenesis; neuron projection morphogenesis; and regulation of synapse structural plasticity. Predicted to act upstream of or within cell adhesion and cell differentiation. Predicted to be located in adherens junction; axon; and cytoplasm. Is expressed in female organism. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations. Orthologous to human CTNNA2 (catenin alpha 2). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ctnna2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (42225130..43035729)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (41523882..42334573)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137495652 Neighboring gene uncharacterized LOC137495655 Neighboring gene adrenoceptor alpha 1D Neighboring gene uncharacterized LOC101882853 Neighboring gene leucine rich repeat transmembrane neuronal 1 Neighboring gene succinate-CoA ligase GDP/ADP-forming subunit alph Neighboring gene CDGSH iron sulfur domain 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Blood Flow Suppresses Vascular Anomalies in a Zebrafish Model of Cerebral Cavernous Malformations. Rödel CJ, et al. Circ Res, 2019 Oct 25. PMID 31495257
    2. Non-nuclear Pool of Splicing Factor SFPQ Regulates Axonal Transcripts Required for Normal Motor Development. Thomas-Jinu S, et al. Neuron, 2017 Apr 19. PMID 28392072, Free PMC Article
    3. Ewing sarcoma ewsa protein regulates chondrogenesis of Meckel's cartilage through modulation of Sox9 in zebrafish. Merkes C, et al. PLoS One, 2015. PMID 25617839, Free PMC Article
    4. Embryonic temperature affects muscle fibre recruitment in adult zebrafish: genome-wide changes in gene and microRNA expression associated with the transition from hyperplastic to hypertrophic growth phenotypes. Johnston IA, et al. J Exp Biol, 2009 Jun. PMID 19482995
    5. Brain transcriptome analysis of a familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production. Newman M, et al. Mol Brain, 2019 May 3. PMID 31053140, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cadherin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in axonogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in brain morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell-cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in dendrite morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of synapse structural plasticity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in adherens junction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in axon ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    catenin alpha-2
    Names
    alpha N-catenin
    catenin, alpha 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159372.1 → NP_001152844.1  catenin alpha-2

      See identical proteins and their annotated locations for NP_001152844.1

      Status: PROVISIONAL

      Source sequence(s)
      AL626804, BX927206, CR925858, CT997814, CT998561, CU076051
      UniProtKB/Swiss-Prot
      B7ZC77
      Related
      ENSDARP00000092080.4, ENSDART00000101306.6
      Conserved Domains (1) summary
      pfam01044
      Location:82 → 826
      Vinculin; Vinculin family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      42225130..43035729
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005160072.5 → XP_005160129.1  catenin alpha-2 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B6X9
      Conserved Domains (1) summary
      pfam01044
      Location:82 → 866
      Vinculin; Vinculin family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B7ZC77.1 GenPept UniProtKB/Swiss-Prot:B7ZC77

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.