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    pim3 Pim-3 proto-oncogene, serine/threonine kinase [ Danio rerio (zebrafish) ]

    Gene ID: 565041, updated on 2-Nov-2024

    Summary

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    Official Symbol
    pim3provided by ZNC
    Official Full Name
    Pim-3 proto-oncogene, serine/threonine kinaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050809-111
    See related
    Ensembl:ENSDARG00000055129 AllianceGenome:ZFIN:ZDB-GENE-050809-111
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:113028
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in negative regulation of apoptotic process and regulation of mitotic cell cycle. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm. Orthologous to human PIM3 (Pim-3 proto-oncogene, serine/threonine kinase). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See pim3 in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (29662352..29666902)
    105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (29219345..29223895)

    Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene interleukin 17 receptor E-like Neighboring gene kelch repeat and BTB domain containing 13b Neighboring gene bromodomain containing 1b Neighboring gene TAFA chemokine like family member 5b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RNA structural dynamics regulate early embryogenesis through controlling transcriptome fate and function. Shi B, et al. Genome Biol, 2020 May 18. PMID 32423473, Free PMC Article
    2. IRF2 Cooperates with Phosphoprotein of Spring Viremia of Carp Virus to Suppress Antiviral Response in Zebrafish. Huang W, et al. J Virol, 2022 Nov 23. PMID 36314827, Free PMC Article
    3. Inhibition of the Pim1 oncogene results in diminished visual function. Yin J, et al. PLoS One, 2012. PMID 23300608, Free PMC Article
    4. Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes. Briolat V, et al. J Immunol, 2014 May 1. PMID 24683187
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC113028

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase pim-3
    Names
    pim-3 oncogene
    NP_001030150.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034978.2 → NP_001030150.2  serine/threonine-protein kinase pim-3

      Status: VALIDATED

      Source sequence(s)
      CU570887, EH435775, EH461773, EH552235, EH573361, EH579010, EH596371
      UniProtKB/TrEMBL
      A0A8M1N833, E7FB10
      Related
      ENSDARP00000071912.4, ENSDART00000077445.7
      Conserved Domains (2) summary
      cd14102
      Location:40 → 292
      STKc_PIM3; Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) kinase 3
      pfam00069
      Location:41 → 292
      Pkinase; Protein kinase domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007136.7 Reference GRCz11 Primary Assembly

      Range
      29662352..29666902
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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