fn1a fibronectin 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fn1aprovided by ZNC
Official Full Name: fibronectin 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-000426-1
See related: Ensembl:ENSDARG00000019815 AllianceGenome:ZFIN:ZDB-GENE-000426-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: Fn; fn1; fn2; fb80d10; wu:fb80d10
Summary: Enables integrin binding activity. Acts upstream of or within several processes, including animal organ development; cell migration involved in sprouting angiogenesis; and somite specification. Located in interstitial matrix. Is expressed in several structures, including cardiovascular system; mesoderm; nervous system; tail bud; and yolk. Human ortholog(s) of this gene implicated in calcium oxalate nephrolithiasis; membranoproliferative glomerulonephritis; and spondylometaphyseal dysplasia corner fracture type. Orthologous to human FN1 (fibronectin 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 9

Exon count:: 46

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (15362300..15424723, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (15391097..15453529, complement)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the fibronectin extracellular matrix is essential for cell-surface Vangl2 expression, membrane-protrusive activity and directed migration.
Title: Vangl2-dependent regulation of membrane protrusions and directed migration requires a fibronectin extracellular matrix.
Injection of alpha5beta1 protein rescued the Fibronectin layer and then the myocardial precursor migration in snai1b knockdown embryos.
Title: Snail modulates the assembly of fibronectin via α5 integrin for myocardial migration in zebrafish embryos.
Fibronectin, a main component of the extracellular matrix, is induced and deposited after cardiac damage
Title: Fibronectin is deposited by injury-activated epicardial cells and is necessary for zebrafish heart regeneration.
Fn is essential for patterning interrenal organ formation, by modulating the migratory behavior of both steroidogenic interrenal and chromaffin cells.
Title: Fibronectin mediates correct positioning of the interrenal organ in zebrafish.
Fibronectin deficiency resulted in a dramatic reduction of mesoderm accompanied by endodermal expansion in zebrafish embryos.
Title: Fibronectin mediates mesendodermal cell fate decisions.
Data indicate that focal adhesion kinase (FAK) activity may be a mediator of the integrin alpha5/Fn1 interaction during zebrafish lens fiber morphogenesis.
Title: Integrin α5/fibronectin1 and focal adhesion kinase are required for lens fiber morphogenesis in zebrafish.
reduction of fn1 function enables rescue of cardiac fusion in hand2 mutants
Title: Hand2 ensures an appropriate environment for cardiac fusion by limiting Fibronectin function.
Data show that fn knockdown disrupts myogenesis, and that fn may function to regulate fiber organization and limit fast-twitch muscle fiber length.
Title: Muscle development is disrupted in zebrafish embryos deficient for fibronectin.
Fibronectin regulates epithelial organization during myocardial migration in zebrafish.
Title: Fibronectin regulates epithelial organization during myocardial migration in zebrafish.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

fb80d10.x1 (e-PCR)
- UniSTS:191552

fb80d10.x1 (e-PCR)
- UniSTS:191553

Z6663 (e-PCR)
- UniSTS:204708

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	IDA Inferred from Direct Assay more info	PubMed
enables integrin binding	IGI Inferred from Genetic Interaction more info	PubMed
enables proteoglycan binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within acute-phase response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adrenal gland development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within axis elongation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within axis elongation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cardioblast migration to the midline involved in heart rudiment formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cartilage development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cartilage development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell migration involved in sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-substrate junction assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within embryonic heart tube development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryonic heart tube development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic viscerocranium morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within endocardial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endoderm formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within endoderm formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of epithelial cell apical/basal polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart field specification	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within heart jogging	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lens fiber cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lens morphogenesis in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neural crest cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural crest cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pharyngeal system development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within pharyngeal system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell shape	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within somite specification	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within somitogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within somitogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ventricular system development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in interstitial matrix	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: fibronectin 1a; fibronectin

Names: fibronectin 1; fn1l; nat; natter

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131520.2 → NP_571595.2 fibronectin 1a precursor

Status: VALIDATED

Source sequence(s)

BX323049

UniProtKB/TrEMBL

A0A8M1PBH3, B0S602

Related

ENSDARP00000112231.2, ENSDART00000124346.4

Conserved Domains (6) summary

smart00059
Location:409 → 457

FN2; Fibronectin type 2 domain

smart00058
Location:179 → 223

FN1; Fibronectin type 1 domain

cd00061
Location:2387 → 2426

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

cd00063
Location:2000 → 2080

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:1541 → 1622

fn3; Fibronectin type III domain

pfam00039
Location:224 → 263

fn1; Fibronectin type I domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007120.7 Reference GRCz11 Primary Assembly

Range

15362300..15424723 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009304503.3 → XP_009302778.1 fibronectin isoform X1

UniProtKB/TrEMBL

A0A8M3B2G8

Conserved Domains (6) summary

smart00059
Location:409 → 457

FN2; Fibronectin type 2 domain

smart00058
Location:179 → 223

FN1; Fibronectin type 1 domain

cd00061
Location:2386 → 2425

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

cd00063
Location:1724 → 1811

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00039
Location:224 → 263

fn1; Fibronectin type I domain

pfam00041
Location:1541 → 1622

fn3; Fibronectin type III domain