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    pkp3a plakophilin 3a [ Danio rerio (zebrafish) ]

    Gene ID: 368397, updated on 28-Oct-2024

    Summary

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    Official Symbol
    pkp3aprovided by ZNC
    Official Full Name
    plakophilin 3aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060512-114
    See related
    Ensembl:ENSDARG00000051861 AllianceGenome:ZFIN:ZDB-GENE-060512-114
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    pkp3; wu:fa97f09; wu:fk69a12; zgc:136656
    Summary
    Predicted to enable cadherin binding activity. Predicted to be involved in cell-cell adhesion. Predicted to act upstream of or within cell adhesion. Predicted to be active in several cellular components, including adherens junction; nucleus; and plasma membrane. Is expressed in spinal cord. Orthologous to human PKP3 (plakophilin 3). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
    all
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    Genomic context

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    See pkp3a in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (22151271..22191741, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (22053723..22094180, complement)

    Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene Gse1 coiled-coil protein a Neighboring gene single immunoglobulin and toll-interleukin 1 receptor (TIR) domain Neighboring gene hexosaminidase A (alpha polypeptide) Neighboring gene nuclear receptor subfamily 2, group E, member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Altering presenilin gene activity in zebrafish embryos causes changes in expression of genes with potential involvement in Alzheimer's disease pathogenesis. Newman M, et al. J Alzheimers Dis, 2009. PMID 19158429
    2. Proteolysis regulates cardiomyocyte maturation and tissue integration. Fukuda R, et al. Nat Commun, 2017 Feb 17. PMID 28211472, Free PMC Article
    3. Interferon regulatory factor 6 promotes differentiation of the periderm by activating expression of Grainyhead-like 3. de la Garza G, et al. J Invest Dermatol, 2013 Jan. PMID 22931925, Free PMC Article
    4. Unilateral dampening of Bmp activity by nodal generates cardiac left-right asymmetry. Veerkamp J, et al. Dev Cell, 2013 Mar 25. PMID 23499359
    5. Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Giffen KP, et al. Front Neurosci, 2019. PMID 31680844, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC136656, MGC174236

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cadherin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in animal organ development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    plakophilin-3a
    Names
    plakophilin 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045280.1 → NP_001038745.1  plakophilin-3a

      See identical proteins and their annotated locations for NP_001038745.1

      Status: PROVISIONAL

      Source sequence(s)
      BC116608
      UniProtKB/TrEMBL
      Q1JPT2
      Related
      ENSDARP00000106964.1, ENSDART00000123211.3
      Conserved Domains (3) summary
      cd00020
      Location:394 → 504
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam04499
      Location:502 → 732
      SAPS; SIT4 phosphatase-associated protein
      sd00043
      Location:393 → 418
      ARM; armadillo repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007136.7 Reference GRCz11 Primary Assembly

      Range
      22151271..22191741 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005170678.2 → XP_005170735.1  plakophilin-3a isoform X1

      UniProtKB/TrEMBL
      A0A8M2BHY3
      Conserved Domains (3) summary
      cd00020
      Location:316 → 426
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam04499
      Location:424 → 654
      SAPS; SIT4 phosphatase-associated protein
      sd00043
      Location:315 → 340
      ARM; armadillo repeat [structural motif]

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395203.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      1..23943 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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