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    slc4a2a solute carrier family 4 member 2a [ Danio rerio (zebrafish) ]

    Gene ID: 566075, updated on 28-Oct-2024

    Summary

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    Official Symbol
    slc4a2aprovided by ZNC
    Official Full Name
    solute carrier family 4 member 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-051101-2
    See related
    Ensembl:ENSDARG00000028173 AllianceGenome:ZFIN:ZDB-GENE-051101-2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    slc4a2
    Summary
    Enables chloride:bicarbonate antiporter activity. Acts upstream of or within monoatomic anion transport. Located in apical plasma membrane and basolateral plasma membrane. Is expressed in several structures, including cardiovascular system; immature eye; midbrain neural rod; optic tectum; and pronephric duct. Human ortholog(s) of this gene implicated in osteopetrosis. Orthologous to human SLC4A2 (solute carrier family 4 member 2). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
    all
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    Genomic context

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    See slc4a2a in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (32391897..32457941, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (32408671..32474705, complement)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene ArfGAP with SH3 domain, ankyrin repeat and PH domain 1a Neighboring gene upstream binding transcription factor, like Neighboring gene tetratricopeptide repeat domain 19 Neighboring gene Fas apoptotic inhibitory molecule 2a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The slc4a2b gene is required for hair cell development in zebrafish. Qian F, et al. Aging (Albany NY), 2020 Oct 12. PMID 33044947, Free PMC Article
    2. Zebrafish slc4a2/ae2 anion exchanger: cDNA cloning, mapping, functional characterization, and localization. Shmukler BE, et al. Am J Physiol Renal Physiol, 2005 Oct. PMID 15914778
    3. Zebrafish ae2.2 encodes a second slc4a2 anion exchanger. Shmukler BE, et al. Am J Physiol Regul Integr Comp Physiol, 2008 Mar. PMID 18046018
    4. Molecular cloning and functional characterization of zebrafish Slc4a3/Ae3 anion exchanger. Shmukler BE, et al. Pflugers Arch, 2014 Aug. PMID 24668450, Free PMC Article
    5. osr1 is required for podocyte development downstream of wt1a. Tomar R, et al. J Am Soc Nephrol, 2014 Nov. PMID 24722440, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chloride:bicarbonate antiporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables monoatomic anion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables solute:inorganic anion antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in bicarbonate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within monoatomic anion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within monoatomic anion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of intracellular pH IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    anion exchange protein 2a
    Names
    ae2
    ae2.1
    anion exchanger 2
    solute carrier family 4 (anion exchanger), member 2a
    solute carrier family 4, anion exchanger, member 2
    solute carrier family 4, anion exchanger, member 2a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037237.1 → NP_001032314.1  anion exchange protein 2a

      See identical proteins and their annotated locations for NP_001032314.1

      Status: PROVISIONAL

      Source sequence(s)
      AY876015
      UniProtKB/TrEMBL
      Q3KVL6
      Related
      ENSDARP00000041318.4, ENSDART00000041319.6
      Conserved Domains (3) summary
      TIGR00834
      Location:326 → 1227
      ae; anion exchange protein
      pfam00955
      Location:676 → 1155
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:361 → 625
      Band_3_cyto; Band 3 cytoplasmic domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      32391897..32457941 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021480959.2 → XP_021336634.1  anion exchange protein 2a isoform X1

      UniProtKB/TrEMBL
      A0A8M9PZ09
      Conserved Domains (1) summary
      TIGR00834
      Location:345 → 1246
      ae; anion exchange protein

    2. XM_021480957.2 → XP_021336632.1  anion exchange protein 2a isoform X1

      UniProtKB/TrEMBL
      A0A8M9PZ09
      Conserved Domains (1) summary
      TIGR00834
      Location:345 → 1246
      ae; anion exchange protein

    3. XM_068224652.1 → XP_068080753.1  anion exchange protein 2a isoform X2

    4. XM_068224655.1 → XP_068080756.1  anion exchange protein 2a isoform X3

    5. XM_005163511.5 → XP_005163568.1  anion exchange protein 2a isoform X1

      See identical proteins and their annotated locations for XP_005163568.1

      UniProtKB/TrEMBL
      A0A8M9PZ09
      Conserved Domains (1) summary
      TIGR00834
      Location:345 → 1246
      ae; anion exchange protein
    Nucleotide Protein Strain
    Heading Accession and Version

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