prmt7 protein arginine methyltransferase 7 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: prmt7provided by ZNC
Official Full Name: protein arginine methyltransferase 7provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1560
See related: Ensembl:ENSDARG00000051902 AllianceGenome:ZFIN:ZDB-GENE-040426-1560
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:66172
Summary: Predicted to enable histone H4R3 methyltransferase activity and protein-arginine omega-N symmetric methyltransferase activity. Acts upstream of with a negative effect on defense response to virus. Acts upstream of or within with a positive effect on cytoskeleton organization. Predicted to be located in cytosol and nucleus. Is expressed in adaxial cell; brain; eye; otic vesicle; and somite. Orthologous to human PRMT7 (protein arginine methyltransferase 7). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 25

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	25	NC_007136.7 (14408936..14424406, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	25	NC_007136.6 (14312536..14328006, complement)

Chromosome 25 - NC_007136.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

by suppressing the RIG-I-like receptors signaling, zebrafish prmt7 negatively regulates antiviral responses, indicating the vital role of prmt7 and its arginine methyltransferase activity in innate immunity
Title: Zebrafish prmt7 negatively regulates antiviral responses by suppressing the retinoic acid-inducible gene-I-like receptor signaling.
Data show that epiboly relies on the molecular networking of protein arginine methyltransferase 7 (Prmt7) by facilitating syntenin, which acts as a regulator for cytoskeleton.
Title: Prmt7 regulates epiboly and gastrulation cell movements by facilitating syntenin.
Prmt7 regulates epiboly by facilitating 2-OST and modulating actin cytoskeleton
Title: Prmt7 regulates epiboly by facilitating 2-OST and modulating actin cytoskeleton.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables S-adenosylmethionine-dependent methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables histone H4R3 methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-arginine N-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-arginine N-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-arginine omega-N monomethyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-arginine omega-N symmetric methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within_positive_effect cytoskeleton organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within_positive_effect cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_negative_effect defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in genomic imprinting	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within peptidyl-arginine methylation	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-arginine methylation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein methylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in spliceosomal snRNP assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: protein arginine N-methyltransferase 7

Names: Histone-arginine N-methyltransferase PRMT7; [Myelin basic protein]-arginine N-methyltransferase PRMT7

NP_956797.2

EC 2.1.1.321

XP_017209550.1

EC 2.1.1.321

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200503.2 → NP_956797.2 protein arginine N-methyltransferase 7

See identical proteins and their annotated locations for NP_956797.2

Status: PROVISIONAL

Source sequence(s)

AL929309

UniProtKB/Swiss-Prot

A2AV36, Q803G6

Related

ENSDARP00000068099.5, ENSDART00000073609.6

Conserved Domains (1) summary

cl17173
Location:54 → 189

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...