U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    rap1aa RAP1A, member of RAS oncogene family a [ Danio rerio (zebrafish) ]

    Gene ID: 415242, updated on 28-Oct-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    rap1aaprovided by ZNC
    Official Full Name
    RAP1A, member of RAS oncogene family aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040625-167
    See related
    Ensembl:ENSDARG00000012553 AllianceGenome:ZFIN:ZDB-GENE-040625-167
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    rap1a; zgc:86676; wu:fc66g06
    Summary
    Enables MAP kinase kinase activity. Acts upstream of or within chondrocyte intercalation involved in growth plate cartilage morphogenesis and heart development. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in brain. Orthologous to human RAP1A (RAP1A, member of RAS oncogene family). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See rap1aa in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (28267546..28274532, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (28248410..28255479, complement)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel, Shal-related subfamily, member 3 Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 20 Neighboring gene inka box actin regulator 2 Neighboring gene leiomodin 1a (smooth muscle) Neighboring gene lysine demethylase 5Bb

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A Wnt-CKIvarepsilon-Rap1 pathway regulates gastrulation by modulating SIPA1L1, a Rap GTPase activating protein. Tsai IC, et al. Dev Cell, 2007 Mar. PMID 17336901, Free PMC Article
    2. Suppression of Rap1 impairs cardiac myofibrils and conduction system in zebrafish. Dong W, et al. PLoS One, 2012. PMID 23226434, Free PMC Article
    3. RAP1-mediated MEK/ERK pathway defects in Kabuki syndrome. Bögershausen N, et al. J Clin Invest, 2015 Sep. PMID 26280580, Free PMC Article
    4. Rap1b Promotes Notch-Signal-Mediated Hematopoietic Stem Cell Development by Enhancing Integrin-Mediated Cell Adhesion. Rho SS, et al. Dev Cell, 2019 Jun 3. PMID 31006651
    5. Transcriptional study reveals a potential leptin-dependent gene regulatory network in zebrafish brain. Ahi EP, et al. Fish Physiol Biochem, 2021 Aug. PMID 34236575, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RAP1-mediated MEK/ERK pathway defects in Kabuki syndrome.
      Title: RAP1-mediated MEK/ERK pathway defects in Kabuki syndrome.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables G protein activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GDP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase kinase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Rap protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within Rap protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cartilage morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cellular response to cAMP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within chondrocyte intercalation involved in growth plate cartilage morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within convergent extension IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within heart development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of synaptic vesicle exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    RAP1A, member of RAS oncogene family a
    Names
    Rap1b
    NP_001002152.1
    XP_005167080.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002152.1 → NP_001002152.1  RAP1A, member of RAS oncogene family a

      See identical proteins and their annotated locations for NP_001002152.1

      Status: PROVISIONAL

      Source sequence(s)
      BC071360
      UniProtKB/TrEMBL
      A0A8M1N021, Q6IQP4
      Related
      ENSDARP00000050670.6, ENSDART00000050671.8
      Conserved Domains (2) summary
      cd04175
      Location:3 → 167
      Rap1; Rap1 family GTPase consists of Rap1a and Rap1b isoforms
      smart00010
      Location:2 → 168
      small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      28267546..28274532 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005167023.4 → XP_005167080.1  RAP1A, member of RAS oncogene family a isoform X1

      See identical proteins and their annotated locations for XP_005167080.1

      UniProtKB/TrEMBL
      A0A8M1N021, Q6IQP4
      Related
      ENSDARP00000116523.1, ENSDART00000131580.2
      Conserved Domains (2) summary
      cd04175
      Location:3 → 167
      Rap1; Rap1 family GTPase consists of Rap1a and Rap1b isoforms
      smart00010
      Location:2 → 168
      small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous