kif5aa kinesin family member 5A, a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: kif5aaprovided by ZNC
Official Full Name: kinesin family member 5A, aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070912-141
See related: Ensembl:ENSDARG00000098936 AllianceGenome:ZFIN:ZDB-GENE-070912-141
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: vrt; kif5a; vertigo; wu:fj61a10; si:ch211-166e11.4
Summary: Predicted to enable ATP hydrolysis activity; microtubule binding activity; and plus-end-directed microtubule motor activity. Acts upstream of or within axonal transport of mitochondrion and neuron projection maintenance. Predicted to be part of kinesin complex. Predicted to be active in microtubule. Is expressed in gonad; nervous system; neural tube; and trigeminal placode. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; hereditary spastic paraplegia 10; multiple sclerosis; prostate cancer; and rheumatoid arthritis. Orthologous to human KIF5A (kinesin family member 5A). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 9

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (265988..296169, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (266355..296536, complement)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deletion of a kinesin I motor unmasks a mechanism of homeostatic axon-branching control by neurotrophin-3.
Title: Deletion of a kinesin I motor unmasks a mechanism of homeostatic branching control by neurotrophin-3.
Our results shed light on Kinesin complexity and reveal determinants of specific Kif5A functions in mitochondrial transport, adaptor binding, and axonal maintenance.
Title: Unique function of Kinesin Kif5A in localization of mitochondria in axons.

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General gene information

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Markers

fj62b07.y1 (e-PCR)
- UniSTS:199687

fj61a10.x1 (e-PCR)
- UniSTS:199671

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule motor activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables plus-end-directed microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in anterograde dendritic transport of neurotransmitter receptor complex	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within axonal transport of mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within microtubule-based movement	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuron projection maintenance	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neuron projection maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: kinesin family member 5Aa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001199776.1 → NP_001186705.1 kinesin family member 5Aa

Status: VALIDATED

Source sequence(s)

BC095088, CR848672

UniProtKB/TrEMBL

A0A0R4IWI7, A0A8M1NWH1

Related

ENSDARP00000139080.1, ENSDART00000165228.2

Conserved Domains (2) summary

smart00129
Location:9 → 334

KISc; Kinesin motor, catalytic domain. ATPase

cd01369
Location:7 → 327

KISc_KHC_KIF5; Kinesin motor domain, kinesin heavy chain (KHC) or KIF5-like subgroup