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    STMN1 stathmin 1 [ Homo sapiens (human) ]

    Gene ID: 3925, updated on 3-Nov-2024

    Summary

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    Official Symbol
    STMN1provided by HGNC
    Official Full Name
    stathmin 1provided by HGNC
    Primary source
    HGNC:HGNC:6510
    See related
    Ensembl:ENSG00000117632 MIM:151442; AllianceGenome:HGNC:6510
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Lag; SMN; OP18; PP17; PP19; PR22; LAP18; C1orf215
    Summary
    This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
    Expression
    Broad expression in brain (RPKM 118.2), testis (RPKM 64.4) and 20 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See STMN1 in Genome Data Viewer
    Location:
    1p36.11
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (25884179..25906880, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (25721609..25744310, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (26210670..26233371, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene mitochondrial fission regulator 1 like Neighboring gene aurora kinase A and ninein interacting protein Neighboring gene hESC enhancers GRCh37_chr1:26185603-26186228 and GRCh37_chr1:26186229-26186854 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:26189139-26189908 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:26196207-26196708 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 469 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 470 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:26201379-26201878 Neighboring gene progestin and adipoQ receptor family member 7 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:26216402-26217601 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:26217613-26218116 Neighboring gene Sharpr-MPRA regulatory region 13744 Neighboring gene small nuclear ribonucleoprotein polypeptide F pseudogene 2 Neighboring gene ribosomal protein L39 pseudogene 7 Neighboring gene Sharpr-MPRA regulatory region 5934 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 468 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 469 Neighboring gene uncharacterized LOC105376885 Neighboring gene microRNA 3917 Neighboring gene CRISPRi-validated cis-regulatory element chr1.3691 Neighboring gene RNA, U6 small nuclear 110, pseudogene Neighboring gene platelet activating factor acetylhydrolase 2 Neighboring gene NANOG hESC enhancer GRCh37_chr1:26320062-26320573 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 472 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 473 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 474 Neighboring gene small Cajal body-specific RNA 18

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Multiple structural states exist throughout the helical nucleation sequence of the intrinsically disordered protein stathmin, as reported by electron paramagnetic resonance spectroscopy. Chui AJ, et al. Biochemistry, 2015 Mar 10. PMID 25715079
    2. High expression of stathmin 1 is a strong prognostic marker in oral squamous cell carcinoma patients treated by docetaxel-containing regimens. Harada K, et al. Clin Exp Med, 2017 Feb. PMID 26590596
    3. Stathmin prevents the transition from a normal to an endomitotic cell cycle during megakaryocytic differentiation. Iancu-Rubin C, et al. Cell Cycle, 2005 Dec. PMID 16258287
    4. Stathmin drives virus-induced metastasis. Whitehouse A, et al. Oncotarget, 2015 Oct 20. PMID 26450904, Free PMC Article
    5. Decreased stathmin-1 expression inhibits trophoblast proliferation and invasion and is associated with recurrent miscarriage. Tian FJ, et al. Am J Pathol, 2015 Oct. PMID 26272359

    See all (348) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The knockdown of stathmin with si-RNA inhibits invasion of mesothelioma.
      Title: The knockdown of stathmin with si-RNA inhibits invasion of mesothelioma.
    2. STMN1 promotes cell malignancy and bortezomib resistance of multiple myeloma cell lines via PI3K/AKT signaling.
      Title: STMN1 promotes cell malignancy and bortezomib resistance of multiple myeloma cell lines via PI3K/AKT signaling.
    3. Association Between High Expression of Phosphorylated-STMN1 and Mesenchymal Marker Expression and Cancer Stemness in Breast Cancer.
      Title: Association Between High Expression of Phosphorylated-STMN1 and Mesenchymal Marker Expression and Cancer Stemness in Breast Cancer.
    4. Expression of stathmin in asbestos-like fibers-induced mesothelioma: A preliminary report.
      Title: Expression of stathmin in asbestos-like fibers-induced mesothelioma: A preliminary report.
    5. Stathmin 1 and p53 Expression in Cutaneous Squamous Cell Carcinoma and Precursor Lesions.
      Title: Stathmin 1 and p53 Expression in Cutaneous Squamous Cell Carcinoma and Precursor Lesions.
    6. STMN1 as a novel prognostic biomarker in HCC correlating with immune infiltrates and methylation.
      Title: STMN1 as a novel prognostic biomarker in HCC correlating with immune infiltrates and methylation.
    7. Association of Stathmin (Op18) with TNM Staging and Grading of Oral Squamous Cell Carcinoma and Its Role in Tumor Progression.
      Title: Association of Stathmin (Op18) with TNM Staging and Grading of Oral Squamous Cell Carcinoma and Its Role in Tumor Progression.
    8. STMN1 is highly expressed and contributes to clonogenicity in acute promyelocytic leukemia cells.
      Title: STMN1 is highly expressed and contributes to clonogenicity in acute promyelocytic leukemia cells.
    9. Stathmin 1 is a biomarker for diagnosis of microvascular invasion to predict prognosis of early hepatocellular carcinoma.
      Title: Stathmin 1 is a biomarker for diagnosis of microvascular invasion to predict prognosis of early hepatocellular carcinoma.
    10. Overexpression of Stathmin 1 Predicts Poor Prognosis and Promotes Cancer Cell Proliferation and Migration in Ovarian Cancer.
      Title: Overexpression of Stathmin 1 Predicts Poor Prognosis and Promotes Cancer Cell Proliferation and Migration in Ovarian Cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (222)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    integrase gag-pol Using acetylated HIV-1 IN as bait in yeast two-hybrid screening identifies STMN1, a factor involved in microtubule organization, as IN-binding partner PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ32206, MGC138869, MGC138870

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tubulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tubulin binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axonogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in establishment of skin barrier IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in hepatocyte growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in microtubule depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within microtubule depolymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in microtubule depolymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mitotic spindle organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of Rho protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of guanyl-nucleotide exchange factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of microtubule polymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of stress fiber assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of thrombin-activated receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of microtubule polymerization or depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of microtubule polymerization or depolymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to virus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in signal transduction NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    stathmin
    Names
    leukemia-associated phosphoprotein p18
    metablastin
    oncoprotein 18
    phosphoprotein 19
    phosphoprotein p19
    prosolin
    stathmin 1/oncoprotein 18
    testicular tissue protein Li 189
    transmembrane protein C1orf215

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145454.3 → NP_001138926.1  stathmin isoform b

      See identical proteins and their annotated locations for NP_001138926.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) represents the longest transcript, and encodes the longer isoform (b).
      Source sequence(s)
      AK303692, AL033528, BC028398, BG493669
      Consensus CDS
      CCDS44090.1
      UniProtKB/TrEMBL
      A0A140VJW2
      Related
      ENSP00000410452.2, ENST00000426559.7
      Conserved Domains (1) summary
      pfam00836
      Location:9 → 126
      Stathmin; Stathmin family

    2. NM_005563.4 → NP_005554.1  stathmin isoform a

      See identical proteins and their annotated locations for NP_005554.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate terminal exon, compared to variant 4. The resulting isoform (a) has a shorter and distinct C-terminus, compared to isoform b. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AK054594, BG030679, BQ772197
      Consensus CDS
      CCDS269.1
      UniProtKB/Swiss-Prot
      A2A2D1, B2R4E7, B7Z8N4, D3DPJ5, P16949
      UniProtKB/TrEMBL
      B5BU83
      Related
      ENSP00000387858.2, ENST00000455785.7
      Conserved Domains (1) summary
      pfam00836
      Location:5 → 140
      Stathmin; Stathmin family

    3. NM_203399.2 → NP_981944.1  stathmin isoform a

      See identical proteins and their annotated locations for NP_981944.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate terminal exon, compared to variant 4. The resulting isoform (a) has a shorter and distinct C-terminus, compared to isoform b. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AK054594, AL033528, BG030679, BM563894, BQ772197
      Consensus CDS
      CCDS269.1
      UniProtKB/Swiss-Prot
      A2A2D1, B2R4E7, B7Z8N4, D3DPJ5, P16949
      UniProtKB/TrEMBL
      B5BU83
      Related
      ENSP00000350531.2, ENST00000357865.6
      Conserved Domains (1) summary
      pfam00836
      Location:5 → 140
      Stathmin; Stathmin family

    4. NM_203401.2 → NP_981946.1  stathmin isoform a

      See identical proteins and their annotated locations for NP_981946.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR and uses an alternate terminal exon, compared to variant 4. The resulting isoform (a) has a shorter and distinct C-terminus, compared to isoform b. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AK054594, BG030679, BQ428400, BQ772197
      Consensus CDS
      CCDS269.1
      UniProtKB/Swiss-Prot
      A2A2D1, B2R4E7, B7Z8N4, D3DPJ5, P16949
      UniProtKB/TrEMBL
      B5BU83
      Related
      ENSP00000382633.1, ENST00000399728.5
      Conserved Domains (1) summary
      pfam00836
      Location:5 → 140
      Stathmin; Stathmin family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      25884179..25906880 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      25721609..25744310 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_152497.1: Suppressed sequence

      Description
      NM_152497.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P16949.3 GenPept UniProtKB/Swiss-Prot:P16949

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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