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    GULP1 GULP PTB domain containing engulfment adaptor 1 [ Homo sapiens (human) ]

    Gene ID: 51454, updated on 6-Nov-2024

    Summary

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    Official Symbol
    GULP1provided by HGNC
    Official Full Name
    GULP PTB domain containing engulfment adaptor 1provided by HGNC
    Primary source
    HGNC:HGNC:18649
    See related
    Ensembl:ENSG00000144366 MIM:608165; AllianceGenome:HGNC:18649
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CED6; GULP; CED-6
    Summary
    The protein encoded by this gene is an adapter protein necessary for the engulfment of apoptotic cells by phagocytes. Several transcript variants, some protein coding and some thought not to be protein coding, have been found for this gene. [provided by RefSeq, Nov 2011]
    Expression
    Broad expression in endometrium (RPKM 8.3), prostate (RPKM 7.5) and 22 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See GULP1 in Genome Data Viewer
    Location:
    2q32.1-q32.2
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (188291874..188595926)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (188780647..189084760)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (189156601..189460653)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1090 Neighboring gene MPRA-validated peak3993 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16845 Neighboring gene MPRA-validated peak3994 silencer Neighboring gene arkadia (RNF111) N-terminal like PKA signaling regulator 2N pseudogene Neighboring gene Sharpr-MPRA regulatory region 8723 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:189143651-189144345 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:189158453-189159336 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:189163339-189164538 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:189167937-189168854 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:189168855-189169772 Neighboring gene RNA, 5S ribosomal pseudogene 114 Neighboring gene microRNA 561 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:189260185-189260684 Neighboring gene uncharacterized LOC124906107 Neighboring gene uncharacterized LOC105373790 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:189538838-189539338 Neighboring gene disrupted in renal carcinoma 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Gulp1 controls Eph/ephrin trogocytosis and is important for cell rearrangements during development. Gong J, et al. J Cell Biol, 2019 Oct 7. PMID 31409653, Free PMC Article
    2. Engulfment protein GULP is regulator of transforming growth factor-β response in ovarian cells. Ma CI, et al. J Biol Chem, 2012 Jun 8. PMID 22451657, Free PMC Article
    3. GULP1 is a novel APP-interacting protein that alters APP processing. Hao Y, et al. Biochem J, 2011 Jun 15. PMID 21486224
    4. Expression of GULP1 in bronchial epithelium is associated with the progression of emphysema in chronic obstructive pulmonary disease. Datta S, et al. Respir Med, 2017 Mar. PMID 28284325
    5. Engulfment adapter PTB domain containing 1 interacts with and affects processing of the amyloid-β precursor protein. Beyer AS, et al. Neurobiol Aging, 2012 Apr. PMID 20674096

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GULP1 as a Downstream Effector of the Estrogen Receptor-beta Modulates Cisplatin Sensitivity in Bladder Cancer.
      Title: GULP1 as a Downstream Effector of the Estrogen Receptor-β Modulates Cisplatin Sensitivity in Bladder Cancer.
    2. GULP1 regulates the NRF2-KEAP1 signaling axis in urothelial carcinoma.
      Title: GULP1 regulates the NRF2-KEAP1 signaling axis in urothelial carcinoma.
    3. Results indicate that GULP, engulfment adaptor PTB domain containing 1 (GULP1) threonine 35 (T35) phosphorylation is a mechanism for the regulation of GULP1-amyloid beta precursor protein (APP) interaction and thereby APP processing.
      Title: Attenuation of amyloid-β generation by atypical protein kinase C-mediated phosphorylation of engulfment adaptor PTB domain containing 1 threonine 35.
    4. the phagocytic adaptor protein Gulp1 regulates EphB/ephrinB trogocytosis to achieve efficient cell rearrangements of cultured cells and during embryonic development
      Title: Gulp1 controls Eph/ephrin trogocytosis and is important for cell rearrangements during development.
    5. The knockdown of GULP1 and ABR using siRNAs decreased phagocytosis by 40%.
      Title: Genomic/proteomic analyses of dexamethasone-treated human trabecular meshwork cells reveal a role for GULP1 and ABR in phagocytosis.
    6. GULP1 methylation was associated with clinicopathological parameters such as stage III/IV, poorly differentiated grade, residual disease, worse overall and disease specific survival in ovarian cancer.
      Title: Integrated transcriptomic and epigenomic analysis of ovarian cancer reveals epigenetically silenced GULP1.
    7. This study highlights and provides new implications for the role of GULP1 associated molecular mechanism(s) in COPD-emphysema development or progression.
      Title: Expression of GULP1 in bronchial epithelium is associated with the progression of emphysema in chronic obstructive pulmonary disease.
    8. GULP1 only mediates LRP1 transactivation
      Title: Engulfment adaptor phosphotyrosine-binding-domain-containing 1 (GULP1) is a nucleocytoplasmic shuttling protein and is transactivationally active together with low-density lipoprotein receptor-related protein 1 (LRP1).
    9. The apoptotic engulfment protein Ced-6 participates in clathrin-mediated yolk uptake in Drosophila egg chambers.
      Title: The apoptotic engulfment protein Ced-6 participates in clathrin-mediated yolk uptake in Drosophila egg chambers.
    10. GULP expression positively regulates TGF-beta signaling leading to growth inhibition, this may represent an attractive target to achieve TGF-beta responsiveness in ovarian cells.
      Title: Engulfment protein GULP is regulator of transforming growth factor-β response in ovarian cells.
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Upregulation of apoptosis genes such as NCK-associated protein 1, PTB domain adaptor protein CED-6, and TNF receptor superfamily 5 are induced by HIV-1 gp120 in human neurons PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ31156

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phagocytosis, engulfment IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    PTB domain-containing engulfment adapter protein 1
    Names
    GULP, engulfment adaptor PTB domain containing 1
    PTB domain adapter protein CED-6
    PTB domain adaptor protein CED-6
    cell death protein 6 homolog
    engulfment adapter protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252668.2 → NP_001239597.1  PTB domain-containing engulfment adapter protein 1 isoform b

      See identical proteins and their annotated locations for NP_001239597.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 3' end, that causes a frameshift. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      Consensus CDS
      CCDS58742.1
      UniProtKB/TrEMBL
      B3KN52
      Related
      ENSP00000387144.1, ENST00000409843.5
      Conserved Domains (2) summary
      cd01273
      Location:14 → 157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
      pfam10211
      Location:136 → 198
      Ax_dynein_light; Axonemal dynein light chain

    2. NM_001252669.2 → NP_001239598.1  PTB domain-containing engulfment adapter protein 1 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame coding segment compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      Consensus CDS
      CCDS58743.1
      UniProtKB/Swiss-Prot
      Q9UBP9
      Related
      ENSP00000387171.1, ENST00000409805.5
      Conserved Domains (2) summary
      cd14686
      Location:60 → 92
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
      cl17171
      Location:31 → 54
      PH-like; Pleckstrin homology-like domain

    3. NM_001375925.1 → NP_001362854.1  PTB domain-containing engulfment adapter protein 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), as well as variants 1, 5, and 6-10, encodes isoform a.
      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      Consensus CDS
      CCDS2295.1
      UniProtKB/Swiss-Prot
      B2RB51, B4DQ40, B8ZZ72, D3DPH1, E9PB86, Q53PC1, Q53RF3, Q9BVL3, Q9UBP9
      UniProtKB/TrEMBL
      B3KN52
      Related
      ENSP00000352047.3, ENST00000359135.7
      Conserved Domains (2) summary
      cd14686
      Location:163 → 195
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
      cd01273
      Location:14 → 157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain

    4. NM_001375926.1 → NP_001362855.1  PTB domain-containing engulfment adapter protein 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), as well as variants 1, 4, and 6-10, encodes isoform a.
      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      Consensus CDS
      CCDS2295.1
      UniProtKB/Swiss-Prot
      B2RB51, B4DQ40, B8ZZ72, D3DPH1, E9PB86, Q53PC1, Q53RF3, Q9BVL3, Q9UBP9
      UniProtKB/TrEMBL
      B3KN52
      Related
      ENSP00000386289.1, ENST00000409580.5
      Conserved Domains (2) summary
      cd14686
      Location:163 → 195
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
      cd01273
      Location:14 → 157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain

    5. NM_001375927.1 → NP_001362856.1  PTB domain-containing engulfment adapter protein 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), as well as variants 1, 4, 5, and 7-10, encodes isoform a.
      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      Consensus CDS
      CCDS2295.1
      UniProtKB/Swiss-Prot
      B2RB51, B4DQ40, B8ZZ72, D3DPH1, E9PB86, Q53PC1, Q53RF3, Q9BVL3, Q9UBP9
      UniProtKB/TrEMBL
      B3KN52
      Conserved Domains (2) summary
      cd14686
      Location:163 → 195
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
      cd01273
      Location:14 → 157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain

    6. NM_001375928.1 → NP_001362857.1  PTB domain-containing engulfment adapter protein 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), as well as variants 1, 4-6, and 8-10, encodes isoform a.
      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      Consensus CDS
      CCDS2295.1
      UniProtKB/Swiss-Prot
      B2RB51, B4DQ40, B8ZZ72, D3DPH1, E9PB86, Q53PC1, Q53RF3, Q9BVL3, Q9UBP9
      UniProtKB/TrEMBL
      B3KN52
      Conserved Domains (2) summary
      cd14686
      Location:163 → 195
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
      cd01273
      Location:14 → 157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain

    7. NM_001375929.1 → NP_001362858.1  PTB domain-containing engulfment adapter protein 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8), as well as variants 1, 4-7, 9, and 10, encodes isoform a.
      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      Consensus CDS
      CCDS2295.1
      UniProtKB/Swiss-Prot
      B2RB51, B4DQ40, B8ZZ72, D3DPH1, E9PB86, Q53PC1, Q53RF3, Q9BVL3, Q9UBP9
      UniProtKB/TrEMBL
      B3KN52
      Conserved Domains (2) summary
      cd14686
      Location:163 → 195
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
      cd01273
      Location:14 → 157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain

    8. NM_001375930.1 → NP_001362859.1  PTB domain-containing engulfment adapter protein 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9), as well as variants 1, 4-8, and 10, encodes isoform a.
      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      Consensus CDS
      CCDS2295.1
      UniProtKB/Swiss-Prot
      B2RB51, B4DQ40, B8ZZ72, D3DPH1, E9PB86, Q53PC1, Q53RF3, Q9BVL3, Q9UBP9
      UniProtKB/TrEMBL
      B3KN52
      Conserved Domains (2) summary
      cd14686
      Location:163 → 195
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
      cd01273
      Location:14 → 157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain

    9. NM_001375931.1 → NP_001362860.1  PTB domain-containing engulfment adapter protein 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10), as well as variants 1 and 4-9, encodes isoform a.
      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      Consensus CDS
      CCDS2295.1
      UniProtKB/Swiss-Prot
      B2RB51, B4DQ40, B8ZZ72, D3DPH1, E9PB86, Q53PC1, Q53RF3, Q9BVL3, Q9UBP9
      UniProtKB/TrEMBL
      B3KN52
      Conserved Domains (2) summary
      cd14686
      Location:163 → 195
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
      cd01273
      Location:14 → 157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain

    10. NM_001375932.1 → NP_001362861.1  PTB domain-containing engulfment adapter protein 1 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11), as well as variants 12-18, encodes isoform d.
      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      Consensus CDS
      CCDS92915.1
      UniProtKB/TrEMBL
      A0A8V8TQW5
      Related
      ENSP00000514747.1, ENST00000699997.1
      Conserved Domains (2) summary
      cd01273
      Location:14 → 157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
      cl40461
      Location:150 → 191
      ZIP_TSC22D-like; leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins

    11. NM_001375933.1 → NP_001362862.1  PTB domain-containing engulfment adapter protein 1 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12), as well as variants 11 and 13-18, encodes isoform d.
      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      Consensus CDS
      CCDS92915.1
      UniProtKB/TrEMBL
      A0A8V8TQW5
      Conserved Domains (2) summary
      cd01273
      Location:14 → 157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
      cl40461
      Location:150 → 191
      ZIP_TSC22D-like; leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins

    12. NM_001375934.1 → NP_001362863.1  PTB domain-containing engulfment adapter protein 1 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13), as well as variants 11, 12, and 14-18, encodes isoform d.
      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      Consensus CDS
      CCDS92915.1
      UniProtKB/TrEMBL
      A0A8V8TQW5
      Conserved Domains (2) summary
      cd01273
      Location:14 → 157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
      cl40461
      Location:150 → 191
      ZIP_TSC22D-like; leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins

    13. NM_001375935.1 → NP_001362864.1  PTB domain-containing engulfment adapter protein 1 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14), as well as variants 11-13 and 15-18, encodes isoform d.
      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      Consensus CDS
      CCDS92915.1
      UniProtKB/TrEMBL
      A0A8V8TQW5
      Conserved Domains (2) summary
      cd01273
      Location:14 → 157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
      cl40461
      Location:150 → 191
      ZIP_TSC22D-like; leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins

    14. NM_001375936.1 → NP_001362865.1  PTB domain-containing engulfment adapter protein 1 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15), as well as variants 11-14 and 16-18, encodes isoform d.
      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      Consensus CDS
      CCDS92915.1
      UniProtKB/TrEMBL
      A0A8V8TQW5
      Conserved Domains (2) summary
      cd01273
      Location:14 → 157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
      cl40461
      Location:150 → 191
      ZIP_TSC22D-like; leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins

    15. NM_001375937.1 → NP_001362866.1  PTB domain-containing engulfment adapter protein 1 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16), as well as variants 11-15, 17, and 18, encodes isoform d.
      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      Consensus CDS
      CCDS92915.1
      UniProtKB/TrEMBL
      A0A8V8TQW5
      Conserved Domains (2) summary
      cd01273
      Location:14 → 157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
      cl40461
      Location:150 → 191
      ZIP_TSC22D-like; leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins

    16. NM_001375938.1 → NP_001362867.1  PTB domain-containing engulfment adapter protein 1 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17), as well as variants 11-16 and 18, encodes isoform d.
      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      Consensus CDS
      CCDS92915.1
      UniProtKB/TrEMBL
      A0A8V8TQW5
      Conserved Domains (2) summary
      cd01273
      Location:14 → 157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
      cl40461
      Location:150 → 191
      ZIP_TSC22D-like; leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins

    17. NM_001375939.1 → NP_001362868.1  PTB domain-containing engulfment adapter protein 1 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18), as well as variants 11-17, encodes isoform d.
      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      Consensus CDS
      CCDS92915.1
      UniProtKB/TrEMBL
      A0A8V8TQW5
      Conserved Domains (2) summary
      cd01273
      Location:14 → 157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
      cl40461
      Location:150 → 191
      ZIP_TSC22D-like; leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins

    18. NM_001375940.1 → NP_001362869.1  PTB domain-containing engulfment adapter protein 1 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (19), as well as variants 20-22, encodes isoform e.
      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      Conserved Domains (1) summary
      cd01273
      Location:14 → 157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain

    19. NM_001375941.1 → NP_001362870.1  PTB domain-containing engulfment adapter protein 1 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (20), as well as variants 19, 21, and 22, encodes isoform e.
      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      Conserved Domains (1) summary
      cd01273
      Location:14 → 157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain

    20. NM_001375942.1 → NP_001362871.1  PTB domain-containing engulfment adapter protein 1 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (21), as well as variants 19, 20, and 22, encodes isoform e.
      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      Conserved Domains (1) summary
      cd01273
      Location:14 → 157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain

    21. NM_001375943.1 → NP_001362872.1  PTB domain-containing engulfment adapter protein 1 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (22), as well as variants 19-21, encodes isoform e.
      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      Conserved Domains (1) summary
      cd01273
      Location:14 → 157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain

    22. NM_001375944.1 → NP_001362873.1  PTB domain-containing engulfment adapter protein 1 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (23), as well as variants 24-26, encodes isoform f.
      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      UniProtKB/TrEMBL
      B3KN52
      Conserved Domains (2) summary
      TIGR02168
      Location:71 → 154
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl17171
      Location:14 → 111
      PH-like; Pleckstrin homology-like domain

    23. NM_001375945.1 → NP_001362874.1  PTB domain-containing engulfment adapter protein 1 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (24), as well as variants 23, 25, and 26, encodes isoform f.
      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      UniProtKB/TrEMBL
      B3KN52
      Conserved Domains (2) summary
      TIGR02168
      Location:71 → 154
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl17171
      Location:14 → 111
      PH-like; Pleckstrin homology-like domain

    24. NM_001375946.1 → NP_001362875.1  PTB domain-containing engulfment adapter protein 1 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (25), as well as variants 23, 24, and 26, encodes isoform f.
      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      UniProtKB/TrEMBL
      B3KN52
      Conserved Domains (2) summary
      TIGR02168
      Location:71 → 154
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl17171
      Location:14 → 111
      PH-like; Pleckstrin homology-like domain

    25. NM_001375947.1 → NP_001362876.1  PTB domain-containing engulfment adapter protein 1 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (26), as well as variants 23-25, encodes isoform f.
      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      UniProtKB/TrEMBL
      B3KN52
      Conserved Domains (2) summary
      TIGR02168
      Location:71 → 154
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl17171
      Location:14 → 111
      PH-like; Pleckstrin homology-like domain

    26. NM_001375948.1 → NP_001362877.1  PTB domain-containing engulfment adapter protein 1 isoform g

      Status: REVIEWED

      Description
      Transcript Variant: This variant (27), as well as variant 28, encodes the longest isoform (g).
      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      Consensus CDS
      CCDS92916.1
      UniProtKB/TrEMBL
      B3KN52, H7BZV7
      Related
      ENSP00000391712.2, ENST00000433052.2
      Conserved Domains (2) summary
      cd14686
      Location:163 → 195
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
      cd01273
      Location:14 → 157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain

    27. NM_001375949.1 → NP_001362878.1  PTB domain-containing engulfment adapter protein 1 isoform g

      Status: REVIEWED

      Description
      Transcript Variant: This variant (28), as well as variant 27, encodes the longest isoform (g).
      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      Consensus CDS
      CCDS92916.1
      UniProtKB/TrEMBL
      B3KN52, H7BZV7
      Conserved Domains (2) summary
      cd14686
      Location:163 → 195
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
      cd01273
      Location:14 → 157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain

    28. NM_001375950.1 → NP_001362879.1  PTB domain-containing engulfment adapter protein 1 isoform h

      Status: REVIEWED

      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      UniProtKB/TrEMBL
      B3KN52
      Conserved Domains (2) summary
      TIGR02168
      Location:71 → 154
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl17171
      Location:14 → 111
      PH-like; Pleckstrin homology-like domain

    29. NM_001375951.1 → NP_001362880.1  PTB domain-containing engulfment adapter protein 1 isoform i

      Status: REVIEWED

      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      Conserved Domains (2) summary
      cd01273
      Location:3 → 129
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
      pfam10211
      Location:108 → 178
      Ax_dynein_light; Axonemal dynein light chain

    30. NM_001375952.1 → NP_001362881.1  PTB domain-containing engulfment adapter protein 1 isoform j

      Status: REVIEWED

      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      Conserved Domains (2) summary
      cd14686
      Location:139 → 171
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
      cd01273
      Location:14 → 133
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain

    31. NM_001375953.1 → NP_001362882.1  PTB domain-containing engulfment adapter protein 1 isoform k

      Status: REVIEWED

      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490
      Conserved Domains (1) summary
      cl17171
      Location:14 → 111
      PH-like; Pleckstrin homology-like domain

    32. NM_016315.4 → NP_057399.1  PTB domain-containing engulfment adapter protein 1 isoform a

      See identical proteins and their annotated locations for NP_057399.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), as well as variants 4, 5, and 6-10, encodes isoform a.
      Source sequence(s)
      AC092598, AF200715, AK055718, AK314498, AL080142
      Consensus CDS
      CCDS2295.1
      UniProtKB/Swiss-Prot
      B2RB51, B4DQ40, B8ZZ72, D3DPH1, E9PB86, Q53PC1, Q53RF3, Q9BVL3, Q9UBP9
      UniProtKB/TrEMBL
      B3KN52
      Related
      ENSP00000386732.1, ENST00000409830.6
      Conserved Domains (2) summary
      cd14686
      Location:163 → 195
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
      cd01273
      Location:14 → 157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain

    RNA

    1. NR_164744.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490

    2. NR_164745.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC092598, AC104131, AC108493, AC125490

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      188291874..188595926
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006712582.2 → XP_006712645.1  PTB domain-containing engulfment adapter protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006712645.1

      UniProtKB/TrEMBL
      B3KN52, H7BZV7
      Conserved Domains (2) summary
      cd14686
      Location:163 → 195
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
      cd01273
      Location:14 → 157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain

    2. XM_047444715.1 → XP_047300671.1  PTB domain-containing engulfment adapter protein 1 isoform X13

    3. XM_011511333.2 → XP_011509635.1  PTB domain-containing engulfment adapter protein 1 isoform X5

      See identical proteins and their annotated locations for XP_011509635.1

      Conserved Domains (2) summary
      cd14686
      Location:117 → 149
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
      cl17171
      Location:14 → 111
      PH-like; Pleckstrin homology-like domain

    4. XM_047444714.1 → XP_047300670.1  PTB domain-containing engulfment adapter protein 1 isoform X12

    5. XM_011511329.2 → XP_011509631.1  PTB domain-containing engulfment adapter protein 1 isoform X2

      Conserved Domains (2) summary
      cd14686
      Location:163 → 195
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
      cd01273
      Location:14 → 157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain

    6. XM_047444704.1 → XP_047300660.1  PTB domain-containing engulfment adapter protein 1 isoform X9

    7. XM_047444703.1 → XP_047300659.1  PTB domain-containing engulfment adapter protein 1 isoform X9

    8. XM_047444697.1 → XP_047300653.1  PTB domain-containing engulfment adapter protein 1 isoform X6

    9. XM_047444712.1 → XP_047300668.1  PTB domain-containing engulfment adapter protein 1 isoform X12

    10. XM_047444699.1 → XP_047300655.1  PTB domain-containing engulfment adapter protein 1 isoform X7

    11. XM_017004307.2 → XP_016859796.1  PTB domain-containing engulfment adapter protein 1 isoform X10

      Conserved Domains (3) summary
      cd14686
      Location:117 → 149
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
      pfam04880
      Location:121 → 200
      NUDE_C; NUDE protein, C-terminal conserved region
      cl17171
      Location:14 → 111
      PH-like; Pleckstrin homology-like domain

    12. XM_006712589.4 → XP_006712652.1  PTB domain-containing engulfment adapter protein 1 isoform X7

      UniProtKB/TrEMBL
      B3KN52
      Conserved Domains (3) summary
      cd14686
      Location:163 → 195
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
      cd01273
      Location:14 → 157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
      pfam04880
      Location:167 → 246
      NUDE_C; NUDE protein, C-terminal conserved region

    13. XM_011511335.3 → XP_011509637.1  PTB domain-containing engulfment adapter protein 1 isoform X10

      Conserved Domains (3) summary
      cd14686
      Location:117 → 149
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
      pfam04880
      Location:121 → 200
      NUDE_C; NUDE protein, C-terminal conserved region
      cl17171
      Location:14 → 111
      PH-like; Pleckstrin homology-like domain

    14. XM_006712584.5 → XP_006712647.1  PTB domain-containing engulfment adapter protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006712647.1

      UniProtKB/TrEMBL
      B3KN52, H7BZV7
      Conserved Domains (2) summary
      cd14686
      Location:163 → 195
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
      cd01273
      Location:14 → 157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain

    15. XM_047444696.1 → XP_047300652.1  PTB domain-containing engulfment adapter protein 1 isoform X5

    16. XM_047444709.1 → XP_047300665.1  PTB domain-containing engulfment adapter protein 1 isoform X11

    17. XM_006712583.5 → XP_006712646.1  PTB domain-containing engulfment adapter protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006712646.1

      UniProtKB/TrEMBL
      B3KN52, H7BZV7
      Conserved Domains (2) summary
      cd14686
      Location:163 → 195
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
      cd01273
      Location:14 → 157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain

    18. XM_047444702.1 → XP_047300658.1  PTB domain-containing engulfment adapter protein 1 isoform X8

      UniProtKB/Swiss-Prot
      B2RB51, B4DQ40, B8ZZ72, D3DPH1, E9PB86, Q53PC1, Q53RF3, Q9BVL3, Q9UBP9
      Related
      ENSP00000386867.1, ENST00000409609.5

    19. XM_047444710.1 → XP_047300666.1  PTB domain-containing engulfment adapter protein 1 isoform X11

    20. XM_006712580.5 → XP_006712643.1  PTB domain-containing engulfment adapter protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006712643.1

      UniProtKB/TrEMBL
      B3KN52, H7BZV7
      Conserved Domains (2) summary
      cd14686
      Location:163 → 195
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
      cd01273
      Location:14 → 157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain

    21. XM_047444695.1 → XP_047300651.1  PTB domain-containing engulfment adapter protein 1 isoform X5

    22. XM_047444692.1 → XP_047300648.1  PTB domain-containing engulfment adapter protein 1 isoform X2

    23. XM_047444707.1 → XP_047300663.1  PTB domain-containing engulfment adapter protein 1 isoform X9

    24. XM_047444705.1 → XP_047300661.1  PTB domain-containing engulfment adapter protein 1 isoform X9

    25. XM_047444713.1 → XP_047300669.1  PTB domain-containing engulfment adapter protein 1 isoform X12

    26. XM_047444701.1 → XP_047300657.1  PTB domain-containing engulfment adapter protein 1 isoform X7

    27. XM_047444698.1 → XP_047300654.1  PTB domain-containing engulfment adapter protein 1 isoform X7

    28. XM_047444708.1 → XP_047300664.1  PTB domain-containing engulfment adapter protein 1 isoform X10

    29. XM_047444706.1 → XP_047300662.1  PTB domain-containing engulfment adapter protein 1 isoform X9

    30. XM_047444700.1 → XP_047300656.1  PTB domain-containing engulfment adapter protein 1 isoform X7

    31. XM_047444711.1 → XP_047300667.1  PTB domain-containing engulfment adapter protein 1 isoform X11

    32. XM_047444691.1 → XP_047300647.1  PTB domain-containing engulfment adapter protein 1 isoform X2

    33. XM_047444693.1 → XP_047300649.1  PTB domain-containing engulfment adapter protein 1 isoform X4

    34. XM_011511331.2 → XP_011509633.1  PTB domain-containing engulfment adapter protein 1 isoform X3

      Conserved Domains (2) summary
      cd14686
      Location:150 → 182
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
      cd01273
      Location:5 → 144
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain

    35. XM_047444694.1 → XP_047300650.1  PTB domain-containing engulfment adapter protein 1 isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      188780647..189084760
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054342469.1 → XP_054198444.1  PTB domain-containing engulfment adapter protein 1 isoform X1

      UniProtKB/TrEMBL
      H7BZV7

    2. XM_054342503.1 → XP_054198478.1  PTB domain-containing engulfment adapter protein 1 isoform X13

    3. XM_054342478.1 → XP_054198453.1  PTB domain-containing engulfment adapter protein 1 isoform X5

    4. XM_054342502.1 → XP_054198477.1  PTB domain-containing engulfment adapter protein 1 isoform X12

    5. XM_054342474.1 → XP_054198449.1  PTB domain-containing engulfment adapter protein 1 isoform X2

    6. XM_054342491.1 → XP_054198466.1  PTB domain-containing engulfment adapter protein 1 isoform X9

    7. XM_054342490.1 → XP_054198465.1  PTB domain-containing engulfment adapter protein 1 isoform X9

    8. XM_054342481.1 → XP_054198456.1  PTB domain-containing engulfment adapter protein 1 isoform X6

    9. XM_054342501.1 → XP_054198476.1  PTB domain-containing engulfment adapter protein 1 isoform X12

    10. XM_054342484.1 → XP_054198459.1  PTB domain-containing engulfment adapter protein 1 isoform X7

    11. XM_054342497.1 → XP_054198472.1  PTB domain-containing engulfment adapter protein 1 isoform X10

    12. XM_054342482.1 → XP_054198457.1  PTB domain-containing engulfment adapter protein 1 isoform X7

    13. XM_054342495.1 → XP_054198470.1  PTB domain-containing engulfment adapter protein 1 isoform X10

    14. XM_054342471.1 → XP_054198446.1  PTB domain-containing engulfment adapter protein 1 isoform X1

      UniProtKB/TrEMBL
      H7BZV7

    15. XM_054342480.1 → XP_054198455.1  PTB domain-containing engulfment adapter protein 1 isoform X5

    16. XM_054342498.1 → XP_054198473.1  PTB domain-containing engulfment adapter protein 1 isoform X11

    17. XM_054342472.1 → XP_054198447.1  PTB domain-containing engulfment adapter protein 1 isoform X1

      UniProtKB/TrEMBL
      H7BZV7

    18. XM_054342489.1 → XP_054198464.1  PTB domain-containing engulfment adapter protein 1 isoform X8

      UniProtKB/Swiss-Prot
      B2RB51, B4DQ40, B8ZZ72, D3DPH1, E9PB86, Q53PC1, Q53RF3, Q9BVL3, Q9UBP9

    19. XM_054342470.1 → XP_054198445.1  PTB domain-containing engulfment adapter protein 1 isoform X1

      UniProtKB/TrEMBL
      H7BZV7

    20. XM_054342488.1 → XP_054198463.1  PTB domain-containing engulfment adapter protein 1 isoform X8

      UniProtKB/Swiss-Prot
      B2RB51, B4DQ40, B8ZZ72, D3DPH1, E9PB86, Q53PC1, Q53RF3, Q9BVL3, Q9UBP9

    21. XM_054342499.1 → XP_054198474.1  PTB domain-containing engulfment adapter protein 1 isoform X11

    22. XM_054342468.1 → XP_054198443.1  PTB domain-containing engulfment adapter protein 1 isoform X1

      UniProtKB/TrEMBL
      H7BZV7

    23. XM_054342479.1 → XP_054198454.1  PTB domain-containing engulfment adapter protein 1 isoform X5

    24. XM_054342475.1 → XP_054198450.1  PTB domain-containing engulfment adapter protein 1 isoform X2

    25. XM_054342494.1 → XP_054198469.1  PTB domain-containing engulfment adapter protein 1 isoform X9

    26. XM_054342493.1 → XP_054198468.1  PTB domain-containing engulfment adapter protein 1 isoform X9

    27. XM_054342487.1 → XP_054198462.1  PTB domain-containing engulfment adapter protein 1 isoform X7

    28. XM_054342486.1 → XP_054198461.1  PTB domain-containing engulfment adapter protein 1 isoform X7

    29. XM_054342483.1 → XP_054198458.1  PTB domain-containing engulfment adapter protein 1 isoform X7

    30. XM_054342496.1 → XP_054198471.1  PTB domain-containing engulfment adapter protein 1 isoform X10

    31. XM_054342492.1 → XP_054198467.1  PTB domain-containing engulfment adapter protein 1 isoform X9

    32. XM_054342485.1 → XP_054198460.1  PTB domain-containing engulfment adapter protein 1 isoform X7

    33. XM_054342500.1 → XP_054198475.1  PTB domain-containing engulfment adapter protein 1 isoform X11

    34. XM_054342473.1 → XP_054198448.1  PTB domain-containing engulfment adapter protein 1 isoform X2

    35. XM_054342476.1 → XP_054198451.1  PTB domain-containing engulfment adapter protein 1 isoform X3

    36. XM_054342477.1 → XP_054198452.1  PTB domain-containing engulfment adapter protein 1 isoform X4

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UBP9.1 GenPept UniProtKB/Swiss-Prot:Q9UBP9

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