Dusp13b dual specificity phosphatase 13B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dusp13bprovided by MGI
Official Full Name: dual specificity phosphatase 13Bprovided by MGI
Primary source: MGI:MGI:1351599
See related: Ensembl:ENSMUSG00000021768 AllianceGenome:MGI:1351599
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MDSP; TMDP; Dusp13; Gm1203; DUSP13A; TS-DSP6; LMW-DSP6
Summary: Enables protein tyrosine/serine/threonine phosphatase activity. Predicted to be involved in dephosphorylation and negative regulation of MAPK cascade. Predicted to be active in cytoplasm. Is expressed in ductus deferens; epididymis; ileum; and testis. Orthologous to human DUSP13B (dual specificity phosphatase 13B). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Restricted expression toward testis adult (RPKM 101.6) See more
Orthologs: human all
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Genomic context

Location:: 14 A3; 14 11.85 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (21783463..21792947, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (21733395..21748651, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

expression of both MDSP and TMDP proteins was markedly increased at the 3rd week after birth and continued to increase gradually into adulthood, implying that the physiological functions of both DSPs are specific to the mature/late-developing organs
Title: Characterization of two distinct dual specificity phosphatases encoded in alternative open reading frames of a single gene located on human chromosome 10q22.2.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables MAP kinase phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine/serine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine/serine/threonine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein dephosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: dual specificity protein phosphatase 13B

Names: Dsp13-like protein; dual specificity phosphatase 13; dual specificity protein phosphatase 13; dual-specificity tyrosine phosphatase TS-DSP6; muscle-restricted DSP; testis and skeletal muscle-specific dual specificity phosphatase; testis- and skeletal muscle-specific DSP

NP_001361004.1

EC 3.1.3.16

EC 3.1.3.48

NP_001361006.1

EC 3.1.3.16

EC 3.1.3.48

NP_001361007.1

EC 3.1.3.16

EC 3.1.3.48

NP_001361008.1

EC 3.1.3.16

EC 3.1.3.48

NP_038877.2

EC 3.1.3.16

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001374075.1 → NP_001361004.1 dual specificity protein phosphatase 13B isoform 3

Status: REVIEWED

Source sequence(s)

AC151533

Consensus CDS

CCDS88593.1

UniProtKB/TrEMBL

Z4YLI2

Related

ENSMUSP00000112552.3, ENSMUST00000119866.9

Conserved Domains (1) summary

cl28904
Location:146 → 309

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
NM_001374077.1 → NP_001361006.1 dual specificity protein phosphatase 13B isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (4), as well as variants 5 and 6, encodes isoform 4.

Source sequence(s)

AC151533

Consensus CDS

CCDS88592.1

UniProtKB/Swiss-Prot

Q497R2, Q9QYJ7

UniProtKB/TrEMBL

V9GXA1

Related

ENSMUSP00000138972.2, ENSMUST00000184703.8

Conserved Domains (1) summary

cl28904
Location:28 → 191

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
NM_001374078.1 → NP_001361007.1 dual specificity protein phosphatase 13B isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (5), as well as variants 4 and 6, encodes isoform 4.

Source sequence(s)

AC151533

Consensus CDS

CCDS88592.1

UniProtKB/Swiss-Prot

Q497R2, Q9QYJ7

UniProtKB/TrEMBL

V9GXA1

Conserved Domains (1) summary

cl28904
Location:28 → 191

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
NM_001374079.1 → NP_001361008.1 dual specificity protein phosphatase 13B isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (6), as well as variants 4 and 5, encodes isoform 4.

Source sequence(s)

AC151533, BC100421

UniProtKB/Swiss-Prot

Q497R2, Q9QYJ7

UniProtKB/TrEMBL

V9GXA1

Related

ENSMUSP00000113985.2, ENSMUST00000120984.9

Conserved Domains (1) summary

cl28904
Location:28 → 191

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
NM_013849.3 → NP_038877.2 dual specificity protein phosphatase 13B isoform 2

See identical proteins and their annotated locations for NP_038877.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) encodes isoform 2 (also called TMDP) and is found only in testis.

Source sequence(s)

AB027003, AK006247, BX629730

Consensus CDS

CCDS26864.1

UniProtKB/TrEMBL

Q7TNW3, Q9DA25

Related

ENSMUSP00000113305.2, ENSMUST00000120956.8

Conserved Domains (1) summary

cd00127
Location:110 → 253

DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...