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    Ankrd33 ankyrin repeat domain 33 [ Mus musculus (house mouse) ]

    Gene ID: 208258, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ankrd33provided by MGI
    Official Full Name
    ankyrin repeat domain 33provided by MGI
    Primary source
    MGI:MGI:2443398
    See related
    Ensembl:ENSMUSG00000047034 AllianceGenome:MGI:2443398
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Panky; Panky-a; A930021G21Rik
    Summary
    Acts upstream of or within skeletal muscle cell differentiation. Predicted to be located in cytosol and nucleus. Is expressed in pineal gland; retina; retina inner nuclear layer; retina outer nuclear layer; and testis. Orthologous to human ANKRD33 (ankyrin repeat domain 33). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Ankrd33 in Genome Data Viewer
    Location:
    15 F1; 15 56.39 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (101013625..101017923)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (101115744..101120028)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene fidgetin-like 2 Neighboring gene predicted gene, 53912 Neighboring gene predicted gene, 41402 Neighboring gene activin A receptor, type II-like 1 Neighboring gene activin A receptor, type 1B Neighboring gene STARR-positive B cell enhancer ABC_E4151 Neighboring gene microRNA 6962

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Panky, a novel photoreceptor-specific ankyrin repeat protein, is a transcriptional cofactor that suppresses CRX-regulated photoreceptor genes. Sanuki R, et al. FEBS Lett, 2010 Feb 19. PMID 20026326
    2. Candidate lung tumor susceptibility genes identified through whole-genome association analyses in inbred mice. Liu P, et al. Nat Genet, 2006 Aug. PMID 16862160
    3. Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation. Rajan S, et al. Physiol Genomics, 2012 Feb 1. PMID 22147266
    4. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
    5. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Studies isolated Panky/Ankrd33, a gene encoding an ankyrin repeat-containing protein and that PANKY inhibited the DNA-binding activity of CRX.
      Title: Panky, a novel photoreceptor-specific ankyrin repeat protein, is a transcriptional cofactor that suppresses CRX-regulated photoreceptor genes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC31569

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within skeletal muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    photoreceptor ankyrin repeat protein
    Names
    ankyrin repeat domain-containing protein 33
    photorecptor ankyrin repeat protein A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355656.1 → NP_001342585.1  photoreceptor ankyrin repeat protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC104834
      Conserved Domains (2) summary
      cd00204
      Location:1 → 118
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:29 → 62
      ANK; ANK repeat [structural motif]

    2. NM_001374225.1 → NP_001361154.1  photoreceptor ankyrin repeat protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC104834
      UniProtKB/Swiss-Prot
      D5G1T0, Q8BXP4, Q8BXP5, Q8R1Z1
      Related
      ENSMUSP00000155584.2, ENSMUST00000229954.2
      Conserved Domains (4) summary
      sd00045
      Location:53 → 85
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:58 → 153
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:18 → 73
      Ank_4; Ankyrin repeats (many copies)
      cl39094
      Location:127 → 192
      Ank_2; Ankyrin repeats (3 copies)

    3. NM_144790.1 → NP_659039.1  photoreceptor ankyrin repeat protein isoform 1

      See identical proteins and their annotated locations for NP_659039.1

      Status: VALIDATED

      Source sequence(s)
      BC022726
      Consensus CDS
      CCDS27845.1
      UniProtKB/Swiss-Prot
      Q8BXP5
      Related
      ENSMUSP00000067028.7, ENSMUST00000070875.8
      Conserved Domains (3) summary
      cd00204
      Location:7 → 128
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:10 → 105
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:5 → 37
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      101013625..101017923
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159294.1 → XP_036015187.1  photoreceptor ankyrin repeat protein isoform X1

      Conserved Domains (2) summary
      sd00045
      Location:29 → 62
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:1 → 95
      Ank_2; Ankyrin repeats (3 copies)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BXP5.2 GenPept UniProtKB/Swiss-Prot:Q8BXP5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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