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    ZNF774 zinc finger protein 774 [ Homo sapiens (human) ]

    Gene ID: 342132, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ZNF774provided by HGNC
    Official Full Name
    zinc finger protein 774provided by HGNC
    Primary source
    HGNC:HGNC:33108
    See related
    Ensembl:ENSG00000196391 AllianceGenome:HGNC:33108
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in colon (RPKM 1.2), brain (RPKM 0.9) and 23 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF774 in Genome Data Viewer
    Location:
    15q26.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (90352284..90362847)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (88108296..88118859)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (90895516..90906079)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:90836949-90837449 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:90843353-90843545 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:90843890-90844650 Neighboring gene RNA, 7SL, cytoplasmic 736, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10074 Neighboring gene GOLGA2 pseudogene 8 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10075 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10076 Neighboring gene GABA type A receptor associated protein like 3 (pseudogene) Neighboring gene Sharpr-MPRA regulatory region 12979 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6819 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:90938763-90939262 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:90938261-90938762 Neighboring gene NADH:ubiquinone oxidoreductase subunit A3 pseudogene 4 Neighboring gene IQ motif containing GTPase activating protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6820 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr15:90955563-90956294 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr15:90957593-90958792 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10077 Neighboring gene MPRA-validated peak2420 silencer Neighboring gene NANOG hESC enhancer GRCh37_chr15:90999383-90999894 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10078

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. ZNF774 is a potent suppressor of hepatocarcinogenesis through dampening the NOTCH2 signaling. Guan C, et al. Oncogene, 2020 Feb. PMID 31659254
    2. Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. Okada Y, et al. Nat Genet, 2012 Mar 25. PMID 22446963
    3. CBFβ stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression. Kim DY, et al. Mol Cell, 2013 Feb 21. PMID 23333304, Free PMC Article
    4. Assessment of community efforts to advance network-based prediction of protein-protein interactions. Wang XW, et al. Nat Commun, 2023 Mar 22. PMID 36949045, Free PMC Article
    5. The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers. Oravcová M, et al. Elife, 2022 Nov 14. PMID 36373674, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZNF774 is a potent suppressor of hepatocarcinogenesis through dampening the NOTCH2 signaling.
      Title: ZNF774 is a potent suppressor of hepatocarcinogenesis through dampening the NOTCH2 signaling.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif upregulates the expression of zinc finger protein 774 (ZNF774) in Vif-expression T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC75360

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 774

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004309.3 → NP_001004309.2  zinc finger protein 774

      See identical proteins and their annotated locations for NP_001004309.2

      Status: VALIDATED

      Source sequence(s)
      AC018946, BC067279, DA017564
      Consensus CDS
      CCDS32330.1
      UniProtKB/Swiss-Prot
      A8K020, Q6NX45
      Related
      ENSP00000346348.3, ENST00000354377.8
      Conserved Domains (4) summary
      COG5048
      Location:152 → 483
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:349 → 369
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:291 → 313
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:305 → 328
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      90352284..90362847
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      88108296..88118859
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NX45.2 GenPept UniProtKB/Swiss-Prot:Q6NX45

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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