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    MLH2 mismatch repair protein MLH2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850722, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MLH2
    Official Full Name
    mismatch repair protein MLH2
    Primary source
    SGD:S000004025
    Locus tag
    YLR035C
    See related
    AllianceGenome:SGD:S000004025; FungiDB:YLR035C; VEuPathDB:YLR035C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to bubble DNA binding activity and heteroduplex DNA loop binding activity. Involved in mismatch repair and reciprocal meiotic recombination. Located in nucleus. Part of MutLbeta complex. Human ortholog(s) of this gene implicated in Lynch syndrome; dermatomyositis; pancreatic ductal carcinoma; and polymyositis. Orthologous to human PMS1 (PMS1 homolog 1, mismatch repair system component). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See MLH2 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (212369..214456, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Rsc58p Neighboring gene putative divalent metal ion transporter SMF3 Neighboring gene tRNA-Ala Neighboring gene gag-pol fusion protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A role for the MutL homologue MLH2 in controlling heteroduplex formation and in regulating between two different crossover pathways in budding yeast. Abdullah MF, et al. Cytogenet Genome Res, 2004. PMID 15467363
    2. Functional specificity of MutL homologs in yeast: evidence for three Mlh1-based heterocomplexes with distinct roles during meiosis in recombination and mismatch correction. Wang TF, et al. Proc Natl Acad Sci U S A, 1999 Nov 23. PMID 10570173, Free PMC Article
    3. Biochemical characterisation of Mer3 helicase interactions and the protection of meiotic recombination intermediates. Altmannova V, et al. Nucleic Acids Res, 2023 May 22. PMID 36942481, Free PMC Article
    4. Identification of MLH2/hPMS1 dominant mutations that prevent DNA mismatch repair function. Reyes GX, et al. Commun Biol, 2020 Dec 10. PMID 33303966, Free PMC Article
    5. Different roles of eukaryotic MutS and MutL complexes in repair of small insertion and deletion loops in yeast. Romanova NV, et al. PLoS Genet, 2013 Oct. PMID 24204320, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Here the authors show that the budding yeast mismatch repair related MutLbeta complex, Mlh1-Mlh2, specifically interacts with the conserved meiotic Mer3 helicase, which recruits it to recombination hotspots, independently of mismatch recognition.
      Title: Concerted action of the MutLβ heterodimer and Mer3 helicase regulates the global extent of meiotic gene conversion.
    2. results support a hypothesis that Mlh1-Mlh2 is a non-essential accessory factor that acts to enhance the activity of Mlh1-Pms1
      Title: Mlh2 is an accessory factor for DNA mismatch repair in Saccharomyces cerevisiae.
    3. absence of Mlh2p allows some crossovers from the MSH4 pathway to traverse the MUS81-dependent pathway
      Title: A role for the MutL homologue MLH2 in controlling heteroduplex formation and in regulating between two different crossover pathways in budding yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent DNA damage sensor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to bubble DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to heteroduplex DNA loop binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mismatched DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiosis I cell cycle process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mismatch repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mismatch repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mismatch repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MutLalpha complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MutLbeta complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of mismatch repair complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mismatch repair protein MLH2
    NP_013135.1
    • Protein involved in mismatch repair and meiotic recombination; only certain frameshift intermediates are mismatch repair substrates; forms a complex with Mlh1p, plays accessory role in stimulating activity of MLH1/PMS1 complex

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      212369..214456 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181922.1 → NP_013135.1  TPA: mismatch repair protein MLH2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013135.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VY37, Q07980
      UniProtKB/TrEMBL
      A7A0U1, B3LT07
      Conserved Domains (1) summary
      COG0323
      Location:2 → 693
      MutL; DNA mismatch repair ATPase MutL [Replication, recombination and repair]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07980.1

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