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    kinA sporulation-specific ATP-dependent protein histidine kinase [ Bacillus subtilis subsp. subtilis str. 168 ]

    Gene ID: 939230, updated on 6-Oct-2023

    Summary

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    Gene symbol
    kinA
    Gene description
    sporulation-specific ATP-dependent protein histidine kinase
    Locus tag
    BSU_13990
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bacillus subtilis subsp. subtilis str. 168 (strain: 168, sub-species: subtilis, type-material: type strain of Bacillus subtilis)
    Lineage
    Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus
    Old locus tag
    BSU13990
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    Genomic context

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    Sequence:
    NC_000964.3 (1470026..1471846)

    NC_000964.3Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene penicillin-binding enzyme for formation of rod-shaped peptidoglycan cell wall Neighboring gene N-acetyl-L,L-diaminopimelate aminotransferase Neighboring gene hypothetical protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000964.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The PAS domains of the major sporulation kinase in Bacillus subtilis play a role in tetramer formation that is essential for the autokinase activity. Kiehler B, et al. Microbiologyopen, 2017 Aug. PMID 28449380, Free PMC Article
    2. Coordination of cell decisions and promotion of phenotypic diversity in B. subtilis via pulsed behavior of the phosphorelay. Schultz D. Bioessays, 2016 May. PMID 26941227
    3. Evidence that Autophosphorylation of the Major Sporulation Kinase in Bacillus subtilis Is Able To Occur in trans. Devi SN, et al. J Bacteriol, 2015 Aug. PMID 26055117, Free PMC Article
    4. Role of the PAS sensor domains in the Bacillus subtilis sporulation kinase KinA. Winnen B, et al. J Bacteriol, 2013 May. PMID 23504013, Free PMC Article
    5. Expression level of a chimeric kinase governs entry into sporulation in Bacillus subtilis. Eswaramoorthy P, et al. J Bacteriol, 2011 Nov. PMID 21926229, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data indicated that the autokinase activity is dependent on the formation of a functional tetramer, which is mediated by, at least, the PAS-B and PAS-C domains.
      Title: The PAS domains of the major sporulation kinase in Bacillus subtilis play a role in tetramer formation that is essential for the autokinase activity.
    2. The pulsed behavior of Spo0A~P allows the introduction of a time delay between the activations of KinA and Spo0A~P. (Review)
      Title: Coordination of cell decisions and promotion of phenotypic diversity in B. subtilis via pulsed behavior of the phosphorelay.
    3. autophosphorylation of the major sporulation histidine kinase KinA is able to occur in trans within the homotetramer complex
      Title: Evidence that Autophosphorylation of the Major Sporulation Kinase in Bacillus subtilis Is Able To Occur in trans.
    4. Findings suggest that dimerization of PAS(B) is important for keeping the catalytic domain of KinA in a functional conformation. We use this information to propose a model for the structure of the N-terminal sensor module of KinA.
      Title: Role of the PAS sensor domains in the Bacillus subtilis sporulation kinase KinA.
    5. Tetramer formation mediated by the N-terminal domain of kinA is important for the kinase activity catalyzed by the C-terminal domain.
      Title: Expression level of a chimeric kinase governs entry into sporulation in Bacillus subtilis.
    6. Sda slows the rate of phosphotransfer from KinA to its target, Spo0F.
      Title: The histidine kinase inhibitor Sda binds near the site of autophosphorylation and may sterically hinder autophosphorylation and phosphotransfer to Spo0F.
    7. we demonstrate that overproduction of the phosphorelay components KinA and Spo0A stimulates cell bundle formation in biofilms, while overproduction of the transition state regulators AbrB and SinR leads to repression of formation of elevated bundles.
      Title: Effects of phosphorelay perturbations on architecture, sporulation, and spore resistance in biofilms of Bacillus subtilis.
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    General gene information

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    Homology

    General protein information

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    Preferred Names
    sporulation-specific ATP-dependent protein histidine kinase
    NP_389282.1
    • Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11734624, 14629015, 17350039, 21097618, 22303282, 23169620, 23378509, 23504013, 26712348, 28449380; Product type e: enzyme

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000964.3 Reference assembly

      Range
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      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_389282.1 sporulation-specific ATP-dependent protein histidine kinase [Bacillus subtilis subsp. subtilis str. 168]

      See identical proteins and their annotated locations for NP_389282.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6M3ZDP2
      Conserved Domains (3) summary
      COG2202
      Location:19 → 259
      PAS; PAS domain [Signal transduction mechanisms]
      PRK11360
      Location:262 → 604
      PRK11360; two-component system sensor histidine kinase AtoS
      pfam00989
      Location:144 → 252
      PAS; PAS fold
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P16497.2

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