PRKCD protein kinase C delta [Homo sapiens (human)] - Gene

Summary

Official Symbol: PRKCDprovided by HGNC
Official Full Name: protein kinase C deltaprovided by HGNC
Primary source: HGNC:HGNC:9399
See related: Ensembl:ENSG00000163932 MIM:176977; AllianceGenome:HGNC:9399
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MAY1; PKCD; ALPS3; CVID9; nPKC-delta
Summary: The protein encoded by this gene is a member of the protein kinase C family of serine- and threonine-specific protein kinases. The encoded protein is activated by diacylglycerol and is both a tumor suppressor and a positive regulator of cell cycle progression. Also, this protein can positively or negatively regulate apoptosis. Defects in this gene are a cause of autoimmune lymphoproliferative syndrome. [provided by RefSeq, Aug 2017]
Expression: Ubiquitous expression in adrenal (RPKM 23.1), bone marrow (RPKM 21.7) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 3p21.1

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (53161209..53192717)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (53194119..53225596)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (53195225..53226733)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PKCdelta serves as a potential biomarker and therapeutic target for microglia-mediated neuroinflammation in Alzheimer's disease.
Title: PKCδ serves as a potential biomarker and therapeutic target for microglia-mediated neuroinflammation in Alzheimer's disease.
PKCdelta-mediated SGLT1 upregulation confers the acquired resistance of NSCLC to EGFR TKIs.
Title: PKCδ-mediated SGLT1 upregulation confers the acquired resistance of NSCLC to EGFR TKIs.
Metabolic reprogramming contributes to radioprotection by protein kinase Cdelta.
Title: Metabolic reprogramming contributes to radioprotection by protein kinase Cδ.
Superbinder based phosphoproteomic landscape revealed PRKCD_pY313 mediates the activation of Src and p38 MAPK to promote TNBC progression.
Title: Superbinder based phosphoproteomic landscape revealed PRKCD_pY313 mediates the activation of Src and p38 MAPK to promote TNBC progression.
Activated PRKCD-mediated neutrophil extracellular traps pathway may be the prothrombotic mechanism of neutrophils in polycythemia vera patients based on clinical retrospective analysis and bioinformatics study.
Title: Activated PRKCD-mediated neutrophil extracellular traps pathway may be the prothrombotic mechanism of neutrophils in polycythemia vera patients based on clinical retrospective analysis and bioinformatics study.
Protein kinase C delta regulates mononuclear phagocytes and hinders response to immunotherapy in cancer.
Title: Protein kinase C delta regulates mononuclear phagocytes and hinders response to immunotherapy in cancer.
TRIM69 suppressed the anoikis resistance and metastasis of gastric cancer through ubiquitin-proteasome-mediated degradation of PRKCD.
Title: TRIM69 suppressed the anoikis resistance and metastasis of gastric cancer through ubiquitin‒proteasome-mediated degradation of PRKCD.
Phenotypic Variability in PRKCD: a Review of the Literature.
Title: Phenotypic Variability in PRKCD: a Review of the Literature.
Thrombin-Induced COX-2 Expression and PGE2 Synthesis in Human Tracheal Smooth Muscle Cells: Role of PKCdelta/Pyk2-Dependent AP-1 Pathway Modulation.
Title: Thrombin-Induced COX-2 Expression and PGE(2) Synthesis in Human Tracheal Smooth Muscle Cells: Role of PKCδ/Pyk2-Dependent AP-1 Pathway Modulation.
Protein Kinase C Modulation Determines the Mesoderm/Extraembryonic Fate Under BMP4 Induction From Human Pluripotent Stem Cells.
Title: Protein Kinase C Modulation Determines the Mesoderm/Extraembryonic Fate Under BMP4 Induction From Human Pluripotent Stem Cells.

Submit: New GeneRIF Correction See all GeneRIFs (442)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Autoimmune lymphoproliferative syndrome, type III caused by mutation in PRKCD MedGen: C3809928 OMIM: 615559 GeneReviews: Not available	Compare labs

EBI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 activates forward trafficking and surface clustering of NMDA receptors in membrane microdomains by a PKA-dependent phosphorylation of the NR1 C-terminal Ser897, followed by a PKC-dependent phosphorylation of Ser896	PubMed
	env	Down modulation of the interaction between HIV-1 gp120 and CD4 by TPA is blocked by protein kinase C (PKC) inhibitors, suggesting PKC may play an important role in HIV-1 infection	PubMed
	env	c-FLIPL inhibits Bax activation via modulating PKC expression at the transcriptional level involving AP-2 during gp120 treatment	PubMed
	env	Pre-treatment of endothelial cells with fibroblast growth factor 2 (FGF2) protects cells from HIV-1 gp120 angiotoxicity; this protection is regulated by crosstalk among the ERK, PI3K-AKT and PKC signaling pathways	PubMed
	env	Induction of apoptosis in cell cultures through binding of HIV-1 gp120 or gp160 to CXCR4 involves protein kinase C, basic fibroblast growth factor, caspase-3, and the pro-apoptotic molecule Bax	PubMed
	env	HIV-1 gp120 increases the levels of calcium-dependent and -independent PKC isozymes; the most striking change is observed in PKC-zeta isozyme levels	PubMed
	env	A specific interaction between CD4 and HIV-1 gp120 is required for phosphorylation of CD4, which could involve protein kinase C	PubMed
	env	IL-16 induces rapid translocation of PKC from the cytosol to the membrane in CD4+ cells; PKC inhibitors completely block IL-16-induced lymphocyte migration as well as the motile response induced by HIV-1 gp120 and anti-CD4 antibody binding to CD4	PubMed
Envelope surface glycoprotein gp160, precursor	env	HIV-1 gp160-induced AP-1 complex formation is dependent upon protein tyrosine phosphorylation and is abolished by inhibitors of protein kinase C, but it is unaffected by calcium channel blockers or cyclosporine A	PubMed
Envelope transmembrane glycoprotein gp41	env	A synthetic peptide corresponding to cytoplasmic domain residues 828-848 of HIV-1 gp41 inhibits pKC-catalysed phosphorylation of a protein substrate	PubMed
	env	A synthetic peptide containing residues 581-597 from HIV-1 gp41 inhibits protein kinase C (pkC)-mediated phosphorylation of the CD3 gamma-chain in intact cells and directly inhibits partially purified pkC	PubMed
Nef	nef	The Nef/hnRNPK/PKC-delta/Hck protein complex activates Pak2 activity but inhibits Pak1 activity, which induces paxillin phosphorylation on Ser272/274 and regulates paxillin/TACE association and secretion	PubMed
	nef	The Nef/hnRNPK/PKC-delta/Hck protein complex increases paxillin phosphorylation at Y118 and activates and secretes TACE through Erk1/2 activation	PubMed
	nef	In the context of Nef-associated kinase complex (NAKC), hnRNP-K interacts with HIV-1 Nef and recruits LCK, PKCdelta, and PI-3 kinase	PubMed
Tat	tat	Phospholipase C/protein kinase C signaling pathway-dependent phosphorylation of p44/42 and JNK MAP kinases participates partially in IL-1beta induction by TAT	PubMed
	tat	Tat-triggered PKCdelta and PKCtheta activation results in the downstream signaling through the apoptosis pathways mediated by both ERK1/2 and caspase-3	PubMed
	tat	HIV-1 Tat-mediated stimulation of IL-10 production through the activation of PKC delta, but not TNF-alpha, requires p38 MAP kinase in human macrophages	PubMed
	tat	HIV-1 Tat-mediated stimulation of IL-10 and TNF-alpha production through the activation of PKC delta requires ERK1/2 MAP kinase and NF-kappaB transcription factor in human macrophages	PubMed
	tat	Protein kinase C is required for HIV-1 Tat-mediated transactivation of the viral LTR promoter, indicating protein kinase C regulates the process of HIV-1 transactivation and may play a role in the transition of HIV from latency to productive growth	PubMed
	tat	Protein kinase C phosphorylates HIV-1 Tat on serine residue 46	PubMed
	tat	HIV-1 Tat activates protein kinase C, resulting in the induction of TNF-alpha, IL-6 and IL-10 expression and the secretion of MCP-1	PubMed
matrix	gag	Protein kinase C (PKC) phosphorylates HIV-1 Matrix on serine residue 111 resulting in a shift in localization of Matrix from the cytosol to the cellular membrane, suggesting a myristoyl-protein switch regulated by PKC phosphorylation	PubMed
retropepsin	gag-pol	Phosphorylation of human recombinant vimentin by PKC inhibits the proteolytic processing of the vimentin head domain by HIV-1 protease	PubMed
reverse transcriptase	gag-pol	HIV-1 RT heterodimer expressed in bacteria can be phosphorylated in vitro by several purified mammalian protein kinases including auto-activated protein kinase (PK), CKII, cytosolic protamine kinase (CPK), myelin basic protein kinase 1 (MBPK1), and PRKC	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH12466 (e-PCR)
- UniSTS:22662

D2S2845 (e-PCR)
- UniSTS:9640

RH119270 (e-PCR)
- UniSTS:133832

A007D36 (e-PCR)
- UniSTS:36319

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables calcium,diacylglycerol-dependent serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables diacylglycerol-dependent serine/threonine kinase activity	EXP Inferred from Experiment more info	PubMed
enables diacylglycerol-dependent serine/threonine kinase activity	TAS Traceable Author Statement more info
enables diacylglycerol-dependent, calcium-independent serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables diacylglycerol-dependent, calcium-independent serine/threonine kinase activity	TAS Traceable Author Statement more info	PubMed
enables enzyme activator activity	IDA Inferred from Direct Assay more info	PubMed
enables enzyme binding	IDA Inferred from Direct Assay more info	PubMed
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables insulin receptor substrate binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in B cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in DNA damage response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Fc-gamma receptor signaling pathway involved in phagocytosis	TAS Traceable Author Statement more info
involved_in activation of protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in cell chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to UV	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to angiotensin	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to fatty acid	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to hydrogen peroxide	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to hydroperoxide	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular senescence	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in defense response to bacterium	ISS Inferred from Sequence or Structural Similarity more info
involved_in immunoglobulin mediated immune response	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intrinsic apoptotic signaling pathway in response to oxidative stress	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of actin filament polymerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of filopodium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of glial cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of inflammatory response	IC Inferred by Curator more info	PubMed
involved_in negative regulation of insulin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of peptidyl-tyrosine phosphorylation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of platelet aggregation	ISS Inferred from Sequence or Structural Similarity more info
involved_in neutrophil activation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-threonine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ceramide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endodeoxyribonuclease activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of glucosylceramide catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phospholipid scramblase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of sphingomyelin catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of superoxide anion generation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in post-translational protein modification	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein stabilization	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of ceramide biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of mRNA stability	TAS Traceable Author Statement more info
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in termination of signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in azurophil granule lumen	TAS Traceable Author Statement more info
located_in cell-cell junction	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in endolysosome	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in nuclear matrix	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: protein kinase C delta type

Names: protein kinase C delta VIII; tyrosine-protein kinase PRKCD

NP_001303256.1

EC 2.7.10.2

EC 2.7.11.13

NP_001341605.1

EC 2.7.10.2

EC 2.7.11.13

NP_001341607.1

EC 2.7.10.2

EC 2.7.11.13

NP_001341608.1

EC 2.7.10.2

EC 2.7.11.13

NP_001341609.1

EC 2.7.10.2

EC 2.7.11.13

NP_006245.2

EC 2.7.10.2

EC 2.7.11.13

NP_997704.1

EC 2.7.10.2

EC 2.7.11.13

XP_047304520.1

EC 2.7.10.2

EC 2.7.11.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_033864.2 RefSeqGene

Range

10201..41709

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_1327

mRNA and Protein(s)

NM_001316327.2 → NP_001303256.1 protein kinase C delta type isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 1, 2, 3, 6, and 7 all encode the same isoform (c).

Source sequence(s)

AC097015, AK294272, AK313216, AW293041, BC043350

Consensus CDS

CCDS2870.1

UniProtKB/Swiss-Prot

B0KZ81, B2R834, Q05655, Q15144, Q86XJ6

UniProtKB/TrEMBL

B4DFV1

Conserved Domains (2) summary

cd05620
Location:353 → 668

STKc_nPKC_delta; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C delta

pfam00130
Location:231 → 283

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
NM_001354676.2 → NP_001341605.1 protein kinase C delta type isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (4) encodes the longest isoform (a).

Source sequence(s)

AC097015

UniProtKB/TrEMBL

B4DFV1

Conserved Domains (2) summary

cd05620
Location:372 → 687

STKc_nPKC_delta; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C delta

pfam00130
Location:250 → 302

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
NM_001354678.2 → NP_001341607.1 protein kinase C delta type isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (5) uses an alternate in-frame splice junction compared to variant 4. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.

Source sequence(s)

AC097015

UniProtKB/TrEMBL

B4DFV1

Conserved Domains (2) summary

cd05620
Location:369 → 684

STKc_nPKC_delta; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C delta

pfam00130
Location:247 → 299

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
NM_001354679.2 → NP_001341608.1 protein kinase C delta type isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 1, 2, 3, 6, and 7 all encode the same isoform (c).

Source sequence(s)

AC097015

Consensus CDS

CCDS2870.1

UniProtKB/Swiss-Prot

B0KZ81, B2R834, Q05655, Q15144, Q86XJ6

UniProtKB/TrEMBL

B4DFV1

Related

ENSP00000498623.1, ENST00000650739.1

Conserved Domains (2) summary

cd05620
Location:353 → 668

STKc_nPKC_delta; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C delta

pfam00130
Location:231 → 283

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
NM_001354680.2 → NP_001341609.1 protein kinase C delta type isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 1, 2, 3, 6, and 7 all encode the same isoform (c).

Source sequence(s)

AC097015

Consensus CDS

CCDS2870.1

UniProtKB/Swiss-Prot

B0KZ81, B2R834, Q05655, Q15144, Q86XJ6

UniProtKB/TrEMBL

B4DFV1

Related

ENSP00000498400.1, ENST00000652449.1

Conserved Domains (2) summary

cd05620
Location:353 → 668

STKc_nPKC_delta; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C delta

pfam00130
Location:231 → 283

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
NM_006254.4 → NP_006245.2 protein kinase C delta type isoform c

See identical proteins and their annotated locations for NP_006245.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 1, 2, 3, 6, and 7 all encode the same isoform (c).

Source sequence(s)

AW293041, BC043350, BE048101, CD369320, L07861

Consensus CDS

CCDS2870.1

UniProtKB/Swiss-Prot

B0KZ81, B2R834, Q05655, Q15144, Q86XJ6

UniProtKB/TrEMBL

B4DFV1

Related

ENSP00000331602.3, ENST00000330452.8

Conserved Domains (2) summary

cd05620
Location:353 → 668

STKc_nPKC_delta; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C delta

pfam00130
Location:231 → 283

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
NM_212539.2 → NP_997704.1 protein kinase C delta type isoform c

See identical proteins and their annotated locations for NP_997704.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 1, 2, 3, 6, and 7 all encode the same isoform (c).

Source sequence(s)

AW293041, BC043350, BE048101, CD369320, L07861

Consensus CDS

CCDS2870.1

UniProtKB/Swiss-Prot

B0KZ81, B2R834, Q05655, Q15144, Q86XJ6

UniProtKB/TrEMBL

B4DFV1

Related

ENSP00000378217.2, ENST00000394729.6

Conserved Domains (2) summary

cd05620
Location:353 → 668

STKc_nPKC_delta; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C delta

pfam00130
Location:231 → 283

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)