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    TACC2 transforming acidic coiled-coil containing protein 2 [ Homo sapiens (human) ]

    Gene ID: 10579, updated on 2-Nov-2024

    Summary

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    Official Symbol
    TACC2provided by HGNC
    Official Full Name
    transforming acidic coiled-coil containing protein 2provided by HGNC
    Primary source
    HGNC:HGNC:11523
    See related
    Ensembl:ENSG00000138162 MIM:605302; AllianceGenome:HGNC:11523
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AZU-1; ECTACC
    Summary
    Transforming acidic coiled-coil proteins are a conserved family of centrosome- and microtubule-interacting proteins that are implicated in cancer. This gene encodes a protein that concentrates at centrosomes throughout the cell cycle. This gene lies within a chromosomal region associated with tumorigenesis. Expression of this gene is induced by erythropoietin and is thought to affect the progression of breast tumors. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in heart (RPKM 17.2), skin (RPKM 13.6) and 19 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TACC2 in Genome Data Viewer
    Location:
    10q26.13
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (121989163..122254542)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (122885504..123150842)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (123748678..124014057)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene arginyltransferase 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:123687446-123688312 Neighboring gene Sharpr-MPRA regulatory region 2750 Neighboring gene ATE1 opposite strand, pseudogene Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:123734371-123735166 Neighboring gene uncharacterized LOC124902517 Neighboring gene NSE4 homolog A, SMC5-SMC6 complex component Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:123778189-123779388 Neighboring gene Sharpr-MPRA regulatory region 10515 Neighboring gene Sharpr-MPRA regulatory regions 8460 and 2354 Neighboring gene MPRA-validated peak1120 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:123836619-123837120 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:123844981-123845482 Neighboring gene Sharpr-MPRA regulatory regions 1076 and 11287 Neighboring gene uncharacterized LOC124902518 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:123914119-123915090 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:123931653-123932226 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:123933375-123933946 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:123938237-123938774 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:123939851-123940388 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:123952053-123952808 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:123955355-123956017 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:123959504-123960449 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:123960450-123961394 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:123992934-123993434 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:124005137-124006083 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:124027705-124028206 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:124050601-124051101 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:124053014-124054004 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4142 Neighboring gene BTB domain containing 16 Neighboring gene RNA, U6 small nuclear 728, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A genome-wide association study identifies a locus associated with knee extension strength in older Japanese individuals. Ito S, et al. Commun Biol, 2024 May 20. PMID 38769351, Free PMC Article
    2. High expression of TACC2 in hepatocellular carcinoma is associated with poor prognosis. Shakya M, et al. Cancer Biomark, 2018. PMID 29843208, Free PMC Article
    3. AZU-1: a candidate breast tumor suppressor and biomarker for tumor progression. Chen HM, et al. Mol Biol Cell, 2000 Apr. PMID 10749935, Free PMC Article
    4. Nanopore sequencing reveals TACC2 locus complexity and diversity of isoforms transcribed from an intronic promoter. Ito Y, et al. Sci Rep, 2021 Apr 30. PMID 33931666, Free PMC Article
    5. Cloning and structural characterization of ECTACC, a new member of the transforming acidic coiled coil (TACC) gene family: cDNA sequence and expression analysis in human microvascular endothelial cells. Pu JJ, et al. Cytokine, 2001 Feb 7. PMID 11161455

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A genome-wide association study identifies a locus associated with knee extension strength in older Japanese individuals.
      Title: A genome-wide association study identifies a locus associated with knee extension strength in older Japanese individuals.
    2. Nanopore sequencing reveals TACC2 locus complexity and diversity of isoforms transcribed from an intronic promoter.
      Title: Nanopore sequencing reveals TACC2 locus complexity and diversity of isoforms transcribed from an intronic promoter.
    3. Cigarette smoke exposure enhances transforming acidic coiled-coil-containing protein 2 turnover and thereby promotes emphysema.
      Title: Cigarette smoke exposure enhances transforming acidic coiled-coil-containing protein 2 turnover and thereby promotes emphysema.
    4. TACC2 protein is expressed mainly in the nucleus of the endometrial cancer cells.
      Title: Promoter-level transcriptome in primary lesions of endometrial cancer identified biomarkers associated with lymph node metastasis.
    5. This finding suggests that TACC2 may be a useful tool as a candidate biomarker to predict the recurrence and prognosis of hepatocellular carcinoma.
      Title: High expression of TACC2 in hepatocellular carcinoma is associated with poor prognosis.
    6. These results suggest that TACC2 plays an important role in the cell proliferation of breast carcinoma and therefore immunohistochemical TACC2 status is a candidate of worse prognostic factor in breast cancer cases.
      Title: TACC2 (transforming acidic coiled-coil protein 2) in breast carcinoma as a potent prognostic predictor associated with cell proliferation.
    7. Differential expression of the transcripts TACC2 connects ubiquitin-proteasome system with infection-inflammation in preterm births and preterm premature rupture of membranes.
      Title: Epigenetic regulation of lncRNA connects ubiquitin-proteasome system with infection-inflammation in preterm births and preterm premature rupture of membranes.
    8. Data suggest that TACC2 is highly expressed in prostate cancer cells and contributes to cell cycle progression and cell proliferation in androgen-nonresponsive prostate cancer cells; overexpression of TACC2 leads to recurrence of prostate cancer.
      Title: TACC2 is an androgen-responsive cell cycle regulator promoting androgen-mediated and castration-resistant growth of prostate cancer.
    9. Results revealed 3 genes highly predictive of event-free survival (EFS), beyond age and MLL status: FLT3, IRX2, and TACC2.
      Title: Gene expression profiles predictive of outcome and age in infant acute lymphoblastic leukemia: a Children's Oncology Group study.
    10. TACC2 may mediate an oncogenic effect on breast cancer cells.
      Title: Transforming acidic coiled-coil-containing protein 2 (TACC2) in human breast cancer, expression pattern and clinical/prognostic relevance.
    Submit: New GeneRIF Correction See all GeneRIFs (17)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables nuclear receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cerebral cortex development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    transforming acidic coiled-coil-containing protein 2
    Names
    anti zuai-1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029948.3 RefSeqGene

      Range
      5002..270381
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001291876.2 → NP_001278805.2  transforming acidic coiled-coil-containing protein 2 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks several internal exons in the CDS compared to variant 1. The encoded isoform (e) is shorter than isoform a.
      Source sequence(s)
      AC063960, AL135793, AL731566
      Consensus CDS
      CCDS76348.1
      UniProtKB/TrEMBL
      B2RWP4, E7EMZ9
      Related
      ENSP00000427618.1, ENST00000515603.5
      Conserved Domains (2) summary
      PHA03247
      Location:15 → 468
      PHA03247; large tegument protein UL36; Provisional
      pfam05010
      Location:2620 → 2820
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    2. NM_001291877.2 → NP_001278806.2  transforming acidic coiled-coil-containing protein 2 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks several internal exons and uses an alternate splice site in the CDS compared to variant 1. The encoded isoform (f) is shorter than isoform a.
      Source sequence(s)
      AC063960, AL135793, AL731566
      Consensus CDS
      CCDS76349.1
      UniProtKB/TrEMBL
      B7ZMJ9, E9PBC6
      Related
      ENSP00000424467.1, ENST00000515273.5
      Conserved Domains (2) summary
      PHA03247
      Location:15 → 468
      PHA03247; large tegument protein UL36; Provisional
      pfam05010
      Location:2669 → 2869
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    3. NM_001291878.2 → NP_001278807.1  transforming acidic coiled-coil-containing protein 2 isoform g

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) uses an alternate structure in the 5' UTR and 5' coding region and lacks an internal exon compared to variant 1. The encoded isoform (g) is shorter and has a distinct N-terminus compared to isoform a.
      Source sequence(s)
      AL135793, BC039311, BC141837, R46074
      Consensus CDS
      CCDS76351.1
      UniProtKB/TrEMBL
      D6RAA5
      Related
      ENSP00000422815.1, ENST00000369004.7
      Conserved Domains (3) summary
      pfam05010
      Location:802 → 1002
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam09403
      Location:921 → 1001
      FadA; Adhesion protein FadA
      cl23765
      Location:821 → 923
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    4. NM_001291879.2 → NP_001278808.1  transforming acidic coiled-coil-containing protein 2 isoform h

      See identical proteins and their annotated locations for NP_001278808.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR and coding region and lacks two internal coding exons compared to variant 1. These differences result in the use of a downstream AUG compared to variant 1. The encoded isoform (h) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC063960, AL135793, BC015736, R46074
      Consensus CDS
      CCDS76352.1
      UniProtKB/TrEMBL
      Q4VXL4
      Related
      ENSP00000357997.1, ENST00000369001.5
      Conserved Domains (1) summary
      pfam05010
      Location:369 → 569
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    5. NM_006997.4 → NP_008928.1  transforming acidic coiled-coil-containing protein 2 isoform d

      See identical proteins and their annotated locations for NP_008928.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses a different structure for its 5' UTR and 5' coding region compared to variant 1. The resulting protein (isoform d) has a shorter and distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AF095791, AL135793, BC039311, R46074
      Consensus CDS
      CCDS7627.1
      UniProtKB/Swiss-Prot
      O95359
      Related
      ENSP00000260733.3, ENST00000260733.7
      Conserved Domains (2) summary
      pfam05010
      Location:820 → 1020
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam09403
      Location:939 → 1019
      FadA; Adhesion protein FadA

    6. NM_206860.3 → NP_996742.1  transforming acidic coiled-coil-containing protein 2 isoform c

      See identical proteins and their annotated locations for NP_996742.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses a different structure for its 5' UTR and 5' coding region, and also lacks an internal coding exon compared to variant 1. The resulting protein (isoform c) is shorter and has a distinct N-terminus compared to isoform a.
      Source sequence(s)
      AL135793, BC039311, R46074
      Consensus CDS
      CCDS7628.1
      UniProtKB/Swiss-Prot
      O95359
      Related
      ENSP00000353763.3, ENST00000360561.7
      Conserved Domains (3) summary
      pfam05010
      Location:790 → 990
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam09403
      Location:909 → 989
      FadA; Adhesion protein FadA
      cl11495
      Location:785 → 917
      IncFII_repA; IncFII RepA protein family

    7. NM_206861.3 → NP_996743.1  transforming acidic coiled-coil-containing protein 2 isoform b

      See identical proteins and their annotated locations for NP_996743.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks three internal in-frame exons compared to variant 1. The resulting protein (isoform b) is shorter compared to isoform a. Isoform b has also been called the 'short' isoform
      Source sequence(s)
      AF528098, AL135793, AL731566, R46074
      Consensus CDS
      CCDS7625.1
      UniProtKB/Swiss-Prot
      O95359
      Related
      ENSP00000425062.1, ENST00000513429.5
      Conserved Domains (2) summary
      pfam05010
      Location:888 → 1088
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam09403
      Location:1007 → 1087
      FadA; Adhesion protein FadA

    8. NM_206862.4 → NP_996744.4  transforming acidic coiled-coil-containing protein 2 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Isoform a has also been called the 'long' isoform.
      Source sequence(s)
      AC063960, AL135793, AL731566
      Consensus CDS
      CCDS7626.1
      UniProtKB/Swiss-Prot
      O95359, Q4VXL0, Q4VXL3, Q4VXL6, Q4VXL7, Q5U5T7, Q86WG6, Q86WG7, Q8TCK9, Q9BVQ1, Q9NZ41, Q9NZR5
      UniProtKB/TrEMBL
      B2RWP4
      Related
      ENSP00000358001.1, ENST00000369005.6
      Conserved Domains (2) summary
      pfam05010
      Location:2742 → 2942
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      cl26464
      Location:15 → 468
      Atrophin-1; Atrophin-1 family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      121989163..122254542
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047424457.1 → XP_047280413.1  transforming acidic coiled-coil-containing protein 2 isoform X28

    2. XM_047424465.1 → XP_047280421.1  transforming acidic coiled-coil-containing protein 2 isoform X37

    3. XM_024447756.1 → XP_024303524.1  transforming acidic coiled-coil-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      B2RWP4
      Conserved Domains (3) summary
      pfam05010
      Location:2805 → 3005
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      cl25751
      Location:2185 → 2572
      DUF4045; Domain of unknown function (DUF4045)
      cl26464
      Location:24 → 488
      Atrophin-1; Atrophin-1 family

    4. XM_005269390.1 → XP_005269447.1  transforming acidic coiled-coil-containing protein 2 isoform X6

      UniProtKB/TrEMBL
      B2RWP4
      Conserved Domains (3) summary
      pfam05010
      Location:2774 → 2974
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam09403
      Location:2893 → 2973
      FadA; Adhesion protein FadA
      pfam13863
      Location:2778 → 2879
      DUF4200; Domain of unknown function (DUF4200)

    5. XM_017015485.1 → XP_016870974.1  transforming acidic coiled-coil-containing protein 2 isoform X13

      UniProtKB/TrEMBL
      B2RWP4
      Conserved Domains (3) summary
      PTZ00449
      Location:2185 → 2550
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03247
      Location:24 → 488
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:2756 → 2947
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    6. XM_006717552.1 → XP_006717615.1  transforming acidic coiled-coil-containing protein 2 isoform X21

      UniProtKB/TrEMBL
      B2RWP4
      Conserved Domains (3) summary
      pfam05010
      Location:2697 → 2897
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam09403
      Location:2816 → 2896
      FadA; Adhesion protein FadA
      cl02488
      Location:2736 → 2899
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    7. XM_005269388.1 → XP_005269445.1  transforming acidic coiled-coil-containing protein 2 isoform X3

      See identical proteins and their annotated locations for XP_005269445.1

      UniProtKB/TrEMBL
      B2RWP4
      Conserved Domains (3) summary
      pfam05010
      Location:2793 → 2993
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam09403
      Location:2912 → 2992
      FadA; Adhesion protein FadA
      pfam13863
      Location:2797 → 2898
      DUF4200; Domain of unknown function (DUF4200)

    8. XM_005269392.1 → XP_005269449.1  transforming acidic coiled-coil-containing protein 2 isoform X7

      UniProtKB/TrEMBL
      B2RWP4
      Conserved Domains (3) summary
      pfam05010
      Location:2763 → 2963
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam09403
      Location:2882 → 2962
      FadA; Adhesion protein FadA
      cl02488
      Location:2802 → 2965
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    9. XM_005269396.1 → XP_005269453.1  transforming acidic coiled-coil-containing protein 2 isoform X20

      UniProtKB/TrEMBL
      B2RWP4
      Conserved Domains (3) summary
      pfam05010
      Location:2716 → 2916
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam09403
      Location:2835 → 2915
      FadA; Adhesion protein FadA
      cl02488
      Location:2755 → 2918
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    10. XM_005269393.1 → XP_005269450.1  transforming acidic coiled-coil-containing protein 2 isoform X9

      UniProtKB/TrEMBL
      B2RWP4
      Conserved Domains (3) summary
      pfam05010
      Location:2762 → 2962
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam09403
      Location:2881 → 2961
      FadA; Adhesion protein FadA
      pfam13863
      Location:2766 → 2867
      DUF4200; Domain of unknown function (DUF4200)

    11. XM_017015486.1 → XP_016870975.1  transforming acidic coiled-coil-containing protein 2 isoform X16

      UniProtKB/TrEMBL
      B2RWP4

    12. XM_006717553.1 → XP_006717616.1  transforming acidic coiled-coil-containing protein 2 isoform X24

      UniProtKB/TrEMBL
      B2RWP4
      Conserved Domains (3) summary
      pfam05010
      Location:2685 → 2885
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam09403
      Location:2804 → 2884
      FadA; Adhesion protein FadA
      cl02488
      Location:2724 → 2887
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    13. XM_017015484.1 → XP_016870973.1  transforming acidic coiled-coil-containing protein 2 isoform X4

      UniProtKB/TrEMBL
      B2RWP4

    14. XM_006717548.1 → XP_006717611.1  transforming acidic coiled-coil-containing protein 2 isoform X11

      UniProtKB/TrEMBL
      B2RWP4
      Conserved Domains (3) summary
      pfam05010
      Location:2758 → 2958
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam09403
      Location:2877 → 2957
      FadA; Adhesion protein FadA
      pfam13863
      Location:2762 → 2863
      DUF4200; Domain of unknown function (DUF4200)

    15. XM_017015487.1 → XP_016870976.1  transforming acidic coiled-coil-containing protein 2 isoform X17

      UniProtKB/TrEMBL
      B2RWP4

    16. XM_006717554.1 → XP_006717617.1  transforming acidic coiled-coil-containing protein 2 isoform X25

      UniProtKB/TrEMBL
      B2RWP4
      Conserved Domains (3) summary
      pfam05010
      Location:2681 → 2881
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam09403
      Location:2800 → 2880
      FadA; Adhesion protein FadA
      cl02488
      Location:2720 → 2883
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    17. XM_024447761.1 → XP_024303529.1  transforming acidic coiled-coil-containing protein 2 isoform X10

      UniProtKB/TrEMBL
      B2RWP4
      Conserved Domains (3) summary
      pfam05010
      Location:2760 → 2960
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      cl25751
      Location:2140 → 2527
      DUF4045; Domain of unknown function (DUF4045)
      cl26464
      Location:24 → 488
      Atrophin-1; Atrophin-1 family

    18. XM_047424449.1 → XP_047280405.1  transforming acidic coiled-coil-containing protein 2 isoform X12

    19. XM_047424453.1 → XP_047280409.1  transforming acidic coiled-coil-containing protein 2 isoform X19

    20. XM_047424455.1 → XP_047280411.1  transforming acidic coiled-coil-containing protein 2 isoform X23

    21. XM_005269399.1 → XP_005269456.1  transforming acidic coiled-coil-containing protein 2 isoform X31

      UniProtKB/TrEMBL
      B2RWP4
      Conserved Domains (3) summary
      pfam05010
      Location:2640 → 2840
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam09403
      Location:2759 → 2839
      FadA; Adhesion protein FadA
      pfam13863
      Location:2644 → 2745
      DUF4200; Domain of unknown function (DUF4200)

    22. XM_024447760.1 → XP_024303528.1  transforming acidic coiled-coil-containing protein 2 isoform X8

      UniProtKB/TrEMBL
      B2RWP4
      Conserved Domains (4) summary
      pfam05010
      Location:2763 → 2963
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      cl25751
      Location:2143 → 2530
      DUF4045; Domain of unknown function (DUF4045)
      cl26386
      Location:1526 → 1987
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
      cl26464
      Location:24 → 488
      Atrophin-1; Atrophin-1 family

    23. XM_047424458.1 → XP_047280414.1  transforming acidic coiled-coil-containing protein 2 isoform X30

    24. XM_024447762.1 → XP_024303530.1  transforming acidic coiled-coil-containing protein 2 isoform X18

      UniProtKB/TrEMBL
      B2RWP4
      Conserved Domains (3) summary
      pfam05010
      Location:2718 → 2918
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      cl25751
      Location:2098 → 2485
      DUF4045; Domain of unknown function (DUF4045)
      cl26464
      Location:24 → 488
      Atrophin-1; Atrophin-1 family

    25. XM_047424461.1 → XP_047280417.1  transforming acidic coiled-coil-containing protein 2 isoform X34

    26. XM_017015489.1 → XP_016870978.1  transforming acidic coiled-coil-containing protein 2 isoform X29

      UniProtKB/TrEMBL
      B2RWP4

    27. XM_047424462.1 → XP_047280418.1  transforming acidic coiled-coil-containing protein 2 isoform X35

    28. XM_017015488.1 → XP_016870977.1  transforming acidic coiled-coil-containing protein 2 isoform X26

      UniProtKB/TrEMBL
      B2RWP4

    29. XM_047424463.1 → XP_047280419.1  transforming acidic coiled-coil-containing protein 2 isoform X36

    30. XM_024447763.1 → XP_024303531.1  transforming acidic coiled-coil-containing protein 2 isoform X38

      Conserved Domains (3) summary
      pfam05010
      Location:996 → 1196
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      cl25751
      Location:376 → 763
      DUF4045; Domain of unknown function (DUF4045)
      cl26464
      Location:24 → 222
      Atrophin-1; Atrophin-1 family

    31. XM_024447764.1 → XP_024303532.1  transforming acidic coiled-coil-containing protein 2 isoform X39

      Conserved Domains (2) summary
      pfam05010
      Location:951 → 1151
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      cl25751
      Location:331 → 718
      DUF4045; Domain of unknown function (DUF4045)

    32. XM_011539130.1 → XP_011537432.1  transforming acidic coiled-coil-containing protein 2 isoform X40

      Conserved Domains (3) summary
      pfam05010
      Location:908 → 1108
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam09403
      Location:1027 → 1107
      FadA; Adhesion protein FadA
      cl23765
      Location:927 → 1029
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    33. XM_024447758.1 → XP_024303526.1  transforming acidic coiled-coil-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      B2RWP4
      Conserved Domains (3) summary
      pfam05010
      Location:2804 → 3004
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      cl25751
      Location:2184 → 2571
      DUF4045; Domain of unknown function (DUF4045)
      cl26464
      Location:23 → 487
      Atrophin-1; Atrophin-1 family

    34. XM_024447759.1 → XP_024303527.1  transforming acidic coiled-coil-containing protein 2 isoform X5

      UniProtKB/TrEMBL
      B2RWP4
      Conserved Domains (3) summary
      pfam05010
      Location:2785 → 2985
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      cl25751
      Location:2165 → 2552
      DUF4045; Domain of unknown function (DUF4045)
      cl26464
      Location:15 → 468
      Atrophin-1; Atrophin-1 family

    35. XM_047424451.1 → XP_047280407.1  transforming acidic coiled-coil-containing protein 2 isoform X15

    36. XM_024447757.2 → XP_024303525.1  transforming acidic coiled-coil-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      B2RWP4
      Conserved Domains (3) summary
      pfam05010
      Location:2805 → 3005
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      cl25751
      Location:2185 → 2572
      DUF4045; Domain of unknown function (DUF4045)
      cl26464
      Location:24 → 488
      Atrophin-1; Atrophin-1 family

    37. XM_047424448.1 → XP_047280404.1  transforming acidic coiled-coil-containing protein 2 isoform X5

    38. XM_047424456.1 → XP_047280412.1  transforming acidic coiled-coil-containing protein 2 isoform X27

    39. XM_047424452.1 → XP_047280408.1  transforming acidic coiled-coil-containing protein 2 isoform X15

    40. XM_047424454.1 → XP_047280410.1  transforming acidic coiled-coil-containing protein 2 isoform X22

    41. XM_047424460.1 → XP_047280416.1  transforming acidic coiled-coil-containing protein 2 isoform X33

      UniProtKB/TrEMBL
      E7EMZ9

    42. XM_047424450.1 → XP_047280406.1  transforming acidic coiled-coil-containing protein 2 isoform X14

    43. XM_047424459.1 → XP_047280415.1  transforming acidic coiled-coil-containing protein 2 isoform X32

    44. XM_047424464.1 → XP_047280420.1  transforming acidic coiled-coil-containing protein 2 isoform X37

    45. XM_047424466.1 → XP_047280422.1  transforming acidic coiled-coil-containing protein 2 isoform X43

    46. XM_024447765.2 → XP_024303533.1  transforming acidic coiled-coil-containing protein 2 isoform X41

      Conserved Domains (2) summary
      pfam05010
      Location:863 → 1063
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      cl25751
      Location:243 → 630
      DUF4045; Domain of unknown function (DUF4045)

    47. XM_011539132.3 → XP_011537434.1  transforming acidic coiled-coil-containing protein 2 isoform X42

      UniProtKB/TrEMBL
      Q4VXL8
      Related
      ENSP00000357995.1, ENST00000368999.5
      Conserved Domains (3) summary
      pfam05010
      Location:832 → 1032
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam09403
      Location:951 → 1031
      FadA; Adhesion protein FadA
      cl23765
      Location:851 → 953
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      122885504..123150842
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054364531.1 → XP_054220506.1  transforming acidic coiled-coil-containing protein 2 isoform X28

    2. XM_054364541.1 → XP_054220516.1  transforming acidic coiled-coil-containing protein 2 isoform X37

    3. XM_054364510.1 → XP_054220485.1  transforming acidic coiled-coil-containing protein 2 isoform X8

    4. XM_054364501.1 → XP_054220476.1  transforming acidic coiled-coil-containing protein 2 isoform X1

    5. XM_054364505.1 → XP_054220480.1  transforming acidic coiled-coil-containing protein 2 isoform X4

    6. XM_054364521.1 → XP_054220496.1  transforming acidic coiled-coil-containing protein 2 isoform X18

    7. XM_054364503.1 → XP_054220478.1  transforming acidic coiled-coil-containing protein 2 isoform X2

    8. XM_054364512.1 → XP_054220487.1  transforming acidic coiled-coil-containing protein 2 isoform X10

    9. XM_054364507.1 → XP_054220482.1  transforming acidic coiled-coil-containing protein 2 isoform X5

    10. XM_054364517.1 → XP_054220492.1  transforming acidic coiled-coil-containing protein 2 isoform X15

    11. XM_054364508.1 → XP_054220483.1  transforming acidic coiled-coil-containing protein 2 isoform X6

    12. XM_054364515.1 → XP_054220490.1  transforming acidic coiled-coil-containing protein 2 isoform X13

    13. XM_054364504.1 → XP_054220479.1  transforming acidic coiled-coil-containing protein 2 isoform X3

    14. XM_054364509.1 → XP_054220484.1  transforming acidic coiled-coil-containing protein 2 isoform X7

    15. XM_054364513.1 → XP_054220488.1  transforming acidic coiled-coil-containing protein 2 isoform X11

    16. XM_054364520.1 → XP_054220495.1  transforming acidic coiled-coil-containing protein 2 isoform X17

    17. XM_054364514.1 → XP_054220489.1  transforming acidic coiled-coil-containing protein 2 isoform X12

    18. XM_054364529.1 → XP_054220504.1  transforming acidic coiled-coil-containing protein 2 isoform X26

    19. XM_054364524.1 → XP_054220499.1  transforming acidic coiled-coil-containing protein 2 isoform X21

    20. XM_054364523.1 → XP_054220498.1  transforming acidic coiled-coil-containing protein 2 isoform X20

    21. XM_054364511.1 → XP_054220486.1  transforming acidic coiled-coil-containing protein 2 isoform X9

    22. XM_054364519.1 → XP_054220494.1  transforming acidic coiled-coil-containing protein 2 isoform X16

    23. XM_054364528.1 → XP_054220503.1  transforming acidic coiled-coil-containing protein 2 isoform X25

    24. XM_054364537.1 → XP_054220512.1  transforming acidic coiled-coil-containing protein 2 isoform X34

    25. XM_054364539.1 → XP_054220514.1  transforming acidic coiled-coil-containing protein 2 isoform X36

    26. XM_054364522.1 → XP_054220497.1  transforming acidic coiled-coil-containing protein 2 isoform X19

    27. XM_054364526.1 → XP_054220501.1  transforming acidic coiled-coil-containing protein 2 isoform X23

    28. XM_054364532.1 → XP_054220507.1  transforming acidic coiled-coil-containing protein 2 isoform X29

    29. XM_054364533.1 → XP_054220508.1  transforming acidic coiled-coil-containing protein 2 isoform X30

    30. XM_054364527.1 → XP_054220502.1  transforming acidic coiled-coil-containing protein 2 isoform X24

    31. XM_054364534.1 → XP_054220509.1  transforming acidic coiled-coil-containing protein 2 isoform X31

    32. XM_054364538.1 → XP_054220513.1  transforming acidic coiled-coil-containing protein 2 isoform X35

    33. XM_054364542.1 → XP_054220517.1  transforming acidic coiled-coil-containing protein 2 isoform X38

    34. XM_054364543.1 → XP_054220518.1  transforming acidic coiled-coil-containing protein 2 isoform X39

    35. XM_054364544.1 → XP_054220519.1  transforming acidic coiled-coil-containing protein 2 isoform X40

    36. XM_054364502.1 → XP_054220477.1  transforming acidic coiled-coil-containing protein 2 isoform X1

    37. XM_054364516.1 → XP_054220491.1  transforming acidic coiled-coil-containing protein 2 isoform X14

    38. XM_054364506.1 → XP_054220481.1  transforming acidic coiled-coil-containing protein 2 isoform X5

    39. XM_054364518.1 → XP_054220493.1  transforming acidic coiled-coil-containing protein 2 isoform X15

    40. XM_054364525.1 → XP_054220500.1  transforming acidic coiled-coil-containing protein 2 isoform X22

    41. XM_054364535.1 → XP_054220510.1  transforming acidic coiled-coil-containing protein 2 isoform X32

    42. XM_054364530.1 → XP_054220505.1  transforming acidic coiled-coil-containing protein 2 isoform X27

    43. XM_054364536.1 → XP_054220511.1  transforming acidic coiled-coil-containing protein 2 isoform X33

    44. XM_054364540.1 → XP_054220515.1  transforming acidic coiled-coil-containing protein 2 isoform X37

    45. XM_054364547.1 → XP_054220522.1  transforming acidic coiled-coil-containing protein 2 isoform X43

    46. XM_054364545.1 → XP_054220520.1  transforming acidic coiled-coil-containing protein 2 isoform X43

    47. XM_054364546.1 → XP_054220521.1  transforming acidic coiled-coil-containing protein 2 isoform X43

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O95359.3 GenPept UniProtKB/Swiss-Prot:O95359

    Gene LinkOut

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