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    ATP5F1C ATP synthase F1 subunit gamma [ Homo sapiens (human) ]

    Gene ID: 509, updated on 3-Nov-2024

    Summary

    Official Symbol
    ATP5F1Cprovided by HGNC
    Official Full Name
    ATP synthase F1 subunit gammaprovided by HGNC
    Primary source
    HGNC:HGNC:833
    See related
    Ensembl:ENSG00000165629 MIM:108729; AllianceGenome:HGNC:833
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ATP5C; ATP5C1; ATP5CL1
    Summary
    This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the gamma subunit of the catalytic core. Alternatively spliced transcript variants encoding different isoforms have been identified. This gene also has a pseudogene on chromosome 14. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in heart (RPKM 224.0), adrenal (RPKM 140.8) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ATP5F1C in Genome Data Viewer
    Location:
    10p14
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (7788177..7807801)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (7788947..7808583)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (7830140..7849764)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene inter-alpha-trypsin inhibitor heavy chain 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:7809082-7809283 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2981 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:7830681-7831224 Neighboring gene Kin17 DNA and RNA binding protein Neighboring gene uncharacterized LOC105376392 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:7860144-7860662 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:7860663-7861180 Neighboring gene TATA-box binding protein associated factor 3 Neighboring gene Sharpr-MPRA regulatory region 6244 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:8003953-8004117 Neighboring gene Sharpr-MPRA regulatory region 13617 Neighboring gene uncharacterized LOC105376394

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify subunit gamma 1 of mitochondrial ATP synthase F1 complex (ATP5C1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify subunit gamma 1 of mitochondrial ATP synthase F1 complex (ATP5C1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify subunit gamma 1 of mitochondrial ATP synthase F1 complex (ATP5C1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify subunit gamma 1 of mitochondrial ATP synthase F1 complex (ATP5C1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    capsid gag The interaction of HIV-1 CA with human cellular ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 (ATP5C1) is identified by yeast two-hybrid screen PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by GOA

    General protein information

    Preferred Names
    ATP synthase subunit gamma, mitochondrial
    Names
    ATP synthase gamma chain, mitochondrial
    ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
    F-ATPase gamma subunit
    mitochondrial ATP synthase, gamma subunit 1
    NP_001001973.1
    NP_001307815.1
    NP_005165.1
    XP_016871779.1
    XP_047281210.1
    XP_054221942.1
    XP_054221943.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001973.3NP_001001973.1  ATP synthase subunit gamma, mitochondrial isoform L (liver) precursor

      See identical proteins and their annotated locations for NP_001001973.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript, and encodes the longest isoform (L), also known as a liver type isoform.
      Source sequence(s)
      BC026049, BQ893894, D16562
      Consensus CDS
      CCDS31142.1
      UniProtKB/Swiss-Prot
      A8KA31, P36542, Q5VYP3, Q6I9V2, Q96AS8
      UniProtKB/TrEMBL
      Q8TAS0
      Related
      ENSP00000349142.7, ENST00000356708.12
      Conserved Domains (1) summary
      TIGR01146
      Location:26297
      ATPsyn_F1gamma; ATP synthase, F1 gamma subunit
    2. NM_001320886.2NP_001307815.1  ATP synthase subunit gamma, mitochondrial isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) encodes isoform 3, which lacks a mitochondrial transit peptide compared to isoforms L and H.
      Source sequence(s)
      BC026049, BI603806
      UniProtKB/TrEMBL
      Q8TAS0
      Related
      ENST00000493053.5
      Conserved Domains (1) summary
      TIGR01146
      Location:1250
      ATPsyn_F1gamma; ATP synthase, F1 gamma subunit
    3. NM_005174.4NP_005165.1  ATP synthase subunit gamma, mitochondrial isoform H (heart) precursor

      See identical proteins and their annotated locations for NP_005165.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks a segment in the coding region compared to variant 1. The resulting isoform (H), also known as a heart type isoform, contains a shorter and distinct C-terminus compared to isoform L.
      Source sequence(s)
      BC026049, BQ893894, D16563
      Consensus CDS
      CCDS7081.1
      UniProtKB/TrEMBL
      Q8TAS0
      Related
      ENSP00000338568.4, ENST00000335698.4
      Conserved Domains (1) summary
      TIGR01146
      Location:26297
      ATPsyn_F1gamma; ATP synthase, F1 gamma subunit

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      7788177..7807801
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017016290.2XP_016871779.1  ATP synthase subunit gamma, mitochondrial isoform X2

      UniProtKB/TrEMBL
      B4DL14, Q8TAS0
      Conserved Domains (1) summary
      TIGR01146
      Location:1250
      ATPsyn_F1gamma; ATP synthase, F1 gamma subunit
    2. XM_047425254.1XP_047281210.1  ATP synthase subunit gamma, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      A8KA31, P36542, Q5VYP3, Q6I9V2, Q96AS8

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      7788947..7808583
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054365968.1XP_054221943.1  ATP synthase subunit gamma, mitochondrial isoform X2

      UniProtKB/TrEMBL
      B4DL14
    2. XM_054365967.1XP_054221942.1  ATP synthase subunit gamma, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      A8KA31, P36542, Q5VYP3, Q6I9V2, Q96AS8
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