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    SENP1 SUMO specific peptidase 1 [ Homo sapiens (human) ]

    Gene ID: 29843, updated on 28-Oct-2024

    Summary

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    Official Symbol
    SENP1provided by HGNC
    Official Full Name
    SUMO specific peptidase 1provided by HGNC
    Primary source
    HGNC:HGNC:17927
    See related
    Ensembl:ENSG00000079387 MIM:612157; AllianceGenome:HGNC:17927
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SuPr-2
    Summary
    This gene encodes a cysteine protease that specifically targets members of the small ubiquitin-like modifier (SUMO) protein family. This protease regulates SUMO pathways by deconjugating sumoylated proteins. This protease also functions to process the precursor SUMO proteins into their mature form. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
    Expression
    Broad expression in testis (RPKM 36.5), lymph node (RPKM 5.6) and 18 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SENP1 in Genome Data Viewer
    Location:
    12q13.11
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (48042897..48106079, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (48004645..48067418, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (48436680..48499862, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369752 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:48375074-48375619 Neighboring gene collagen type II alpha 1 chain Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6277 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:48404129-48404630 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:48404631-48405130 Neighboring gene uncharacterized LOC105369750 Neighboring gene uncharacterized LOC124902927 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr12:48415301-48416292 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:48431351-48432291 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr12:48439137-48440336 Neighboring gene ribosomal protein L37 pseudogene 19 Neighboring gene V-type proton ATPase subunit F-like Neighboring gene RNA, U6 small nuclear 1203, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr12:48484832-48485048 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:48498859-48499734 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:48499735-48500608 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6279 Neighboring gene phosphofructokinase, muscle Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:48536214-48537195 Neighboring gene microRNA 6505 Neighboring gene NANOG hESC enhancer GRCh37_chr12:48551082-48551604 Neighboring gene ankyrin repeat and SOCS box containing 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. SUMO-specific protease 1 modulates cadmium-augmented transcriptional activity of androgen receptor (AR) by reversing AR SUMOylation. Wu R, et al. Toxicol Lett, 2014 Sep 2. PMID 25014244
    2. SENP1 regulates hepatocyte growth factor-induced migration and epithelial-mesenchymal transition of hepatocellular carcinoma. Zhang W, et al. Tumour Biol, 2016 Jun. PMID 26695141
    3. SUMO protease SENP1 deSUMOylates and stabilizes c-Myc. Sun XX, et al. Proc Natl Acad Sci U S A, 2018 Oct 23. PMID 30305424, Free PMC Article
    4. Overexpression of SENP1 reduces the stemness capacity of osteosarcoma stem cells and increases their sensitivity to HSVtk/GCV. Liu F, et al. Int J Oncol, 2018 Nov. PMID 30226577, Free PMC Article
    5. Role of desumoylation in the development of prostate cancer. Cheng J, et al. Neoplasia, 2006 Aug. PMID 16925949, Free PMC Article

    See all (189) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SENP1 mediates zinc-induced ZnT6 deSUMOylation at Lys-409 involved in the regulation of zinc metabolism in Golgi apparatus.
      Title: SENP1 mediates zinc-induced ZnT6 deSUMOylation at Lys-409 involved in the regulation of zinc metabolism in Golgi apparatus.
    2. SENP1 knockdown potentiates the apoptosis, cell cycle arrest, and reduces cisplatin resistance of diffuse large B cell lymphoma cells via inducing ferroptosis.
      Title: SENP1 knockdown potentiates the apoptosis, cell cycle arrest, and reduces cisplatin resistance of diffuse large B cell lymphoma cells via inducing ferroptosis.
    3. N6-methyladenosine-modified SENP1, identified by IGF2BP3, is a novel molecular marker in acute myeloid leukemia and aggravates progression by activating AKT signal via de-SUMOylating HDAC2.
      Title: N6-methyladenosine-modified SENP1, identified by IGF2BP3, is a novel molecular marker in acute myeloid leukemia and aggravates progression by activating AKT signal via de-SUMOylating HDAC2.
    4. SENP1-Mediated deSUMOylation Regulates the Tumor Remodeling of Glioma Stem Cells Under Hypoxic Stress.
      Title: SENP1-Mediated deSUMOylation Regulates the Tumor Remodeling of Glioma Stem Cells Under Hypoxic Stress.
    5. METTL3-mediated m[6]A modification of lncRNA TSPAN12 promotes metastasis of hepatocellular carcinoma through SENP1-depentent deSUMOylation of EIF3I.
      Title: METTL3-mediated m(6)A modification of lncRNA TSPAN12 promotes metastasis of hepatocellular carcinoma through SENP1-depentent deSUMOylation of EIF3I.
    6. EHD1 impaired decidualization of endometrial stromal cells in recurrent implantation failure: role of SENP1 in modulating progesterone receptor signallingdagger.
      Title: EHD1 impaired decidualization of endometrial stromal cells in recurrent implantation failure: role of SENP1 in modulating progesterone receptor signalling†.
    7. SENP1 inhibits ferroptosis and promotes head and neck squamous cell carcinoma by regulating ACSL4 protein stability via SUMO1.
      Title: SENP1 inhibits ferroptosis and promotes head and neck squamous cell carcinoma by regulating ACSL4 protein stability via SUMO1.
    8. A role and mechanism for redox sensing by SENP1 in beta-cell responses to high fat feeding.
      Title: A role and mechanism for redox sensing by SENP1 in β-cell responses to high fat feeding.
    9. SENP1-mediated SUMOylation of SIRT1 affects glioma development through the NF-kappaB pathway.
      Title: SENP1-mediated SUMOylation of SIRT1 affects glioma development through the NF-κB pathway.
    10. SENP1 knockdown-mediated CTCF SUMOylation enhanced its stability and alleviated lipopolysaccharide-evoked inflammatory injury in human lung fibroblasts via regulation of FOXA2 transcription.
      Title: SENP1 knockdown-mediated CTCF SUMOylation enhanced its stability and alleviated lipopolysaccharide-evoked inflammatory injury in human lung fibroblasts via regulation of FOXA2 transcription.
    Submit: New GeneRIF Correction See all GeneRIFs (93)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables SUMO-specific endopeptidase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables SUMO-specific endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables deSUMOylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables deSUMOylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables endopeptidase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein desumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein desumoylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein sumoylation TAS
    Traceable Author Statement
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mRNA stability IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of postsynapse assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    		  
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    sentrin-specific protease 1
    Names
    SUMO1/sentrin specific peptidase 1
    SUMO1/sentrin specific protease 1
    sentrin/SUMO-specific protease SENP1
    NP_001254523.1
    NP_001254524.1
    XP_006719424.1
    XP_011536546.1
    XP_011536547.1
    XP_016874718.1
    XP_016874719.1
    XP_016874720.1
    XP_016874721.1
    XP_016874722.1
    XP_016874723.1
    XP_016874724.1
    XP_016874726.1
    XP_047284708.1
    XP_054227853.1
    XP_054227854.1
    XP_054227855.1
    XP_054227856.1
    XP_054227857.1
    XP_054227858.1
    XP_054227859.1
    XP_054227860.1
    XP_054227861.1
    XP_054227862.1
    XP_054227863.1
    XP_054227864.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001267594.2 → NP_001254523.1  sentrin-specific protease 1

      See identical proteins and their annotated locations for NP_001254523.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the functional protein. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC004801, AK312874, BX640784
      Consensus CDS
      CCDS44868.2
      UniProtKB/Swiss-Prot
      A8K7P5, Q86XC8, Q9P0U3
      Related
      ENSP00000447328.1, ENST00000549518.6
      Conserved Domains (1) summary
      cl23802
      Location:420 → 642
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    2. NM_001267595.2 → NP_001254524.1  sentrin-specific protease 1

      See identical proteins and their annotated locations for NP_001254524.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC004801, BC045639, BX537920, BX640784
      Consensus CDS
      CCDS44868.2
      UniProtKB/Swiss-Prot
      A8K7P5, Q86XC8, Q9P0U3
      Related
      ENSP00000394791.2, ENST00000448372.6
      Conserved Domains (1) summary
      cl23802
      Location:420 → 642
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    RNA

    1. NR_051991.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC004801, BX537920, BX640784
      Related
      ENST00000552189.5

    2. NR_051992.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC004801, BX537920, BX640784

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      48042897..48106079 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017019237.2 → XP_016874726.1  sentrin-specific protease 1 isoform X9

    2. XM_017019235.2 → XP_016874724.1  sentrin-specific protease 1 isoform X8

    3. XM_017019232.2 → XP_016874721.1  sentrin-specific protease 1 isoform X4

    4. XM_047428752.1 → XP_047284708.1  sentrin-specific protease 1 isoform X7

    5. XM_011538245.4 → XP_011536547.1  sentrin-specific protease 1 isoform X6

      Conserved Domains (1) summary
      cl23802
      Location:436 → 658
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    6. XM_011538244.4 → XP_011536546.1  sentrin-specific protease 1 isoform X5

      Conserved Domains (1) summary
      cl23802
      Location:439 → 661
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    7. XM_006719361.4 → XP_006719424.1  sentrin-specific protease 1 isoform X3

      See identical proteins and their annotated locations for XP_006719424.1

      Conserved Domains (1) summary
      cl23802
      Location:452 → 674
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    8. XM_017019233.3 → XP_016874722.1  sentrin-specific protease 1 isoform X8

    9. XM_017019230.3 → XP_016874719.1  sentrin-specific protease 1 isoform X2

    10. XM_017019229.3 → XP_016874718.1  sentrin-specific protease 1 isoform X1

    11. XM_017019234.3 → XP_016874723.1  sentrin-specific protease 1 isoform X8

    12. XM_017019231.3 → XP_016874720.1  sentrin-specific protease 1 isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      48004645..48067418 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054371889.1 → XP_054227864.1  sentrin-specific protease 1 isoform X9

    2. XM_054371887.1 → XP_054227862.1  sentrin-specific protease 1 isoform X8

    3. XM_054371881.1 → XP_054227856.1  sentrin-specific protease 1 isoform X4

    4. XM_054371885.1 → XP_054227860.1  sentrin-specific protease 1 isoform X7

    5. XM_054371884.1 → XP_054227859.1  sentrin-specific protease 1 isoform X6

    6. XM_054371883.1 → XP_054227858.1  sentrin-specific protease 1 isoform X5

    7. XM_054371880.1 → XP_054227855.1  sentrin-specific protease 1 isoform X3

    8. XM_054371888.1 → XP_054227863.1  sentrin-specific protease 1 isoform X8

    9. XM_054371879.1 → XP_054227854.1  sentrin-specific protease 1 isoform X2

    10. XM_054371878.1 → XP_054227853.1  sentrin-specific protease 1 isoform X1

    11. XM_054371886.1 → XP_054227861.1  sentrin-specific protease 1 isoform X8

    12. XM_054371882.1 → XP_054227857.1  sentrin-specific protease 1 isoform X4

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_014554.2: Suppressed sequence

      Description
      NM_014554.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9P0U3.2 GenPept UniProtKB/Swiss-Prot:Q9P0U3

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