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    ZNF563 zinc finger protein 563 [ Homo sapiens (human) ]

    Gene ID: 147837, updated on 2-Nov-2024

    Summary

    Official Symbol
    ZNF563provided by HGNC
    Official Full Name
    zinc finger protein 563provided by HGNC
    Primary source
    HGNC:HGNC:30498
    See related
    Ensembl:ENSG00000188868 AllianceGenome:HGNC:30498
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis (RPKM 5.0), prostate (RPKM 2.0) and 22 other tissues See more
    Orthologs
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    Genomic context

    See ZNF563 in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (12317477..12347390, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (12445840..12475737, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (12428291..12444447, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 44 Neighboring gene ribosomal protein L28 pseudogene 5 Neighboring gene MPRA-validated peak3363 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10146 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14048 Neighboring gene ribosomal protein S2 pseudogene 53 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14049 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14050 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14051 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:12444503-12445368 Neighboring gene zinc finger protein 442 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10148 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14052 Neighboring gene ribosomal protein S29 pseudogene 23 Neighboring gene NANOG hESC enhancer GRCh37_chr19:12501177-12501678 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14053 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10149 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14054 Neighboring gene zinc finger protein 799

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ34797

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363608.1NP_001350537.1  zinc finger protein 563 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC012618, BC022523
      Consensus CDS
      CCDS86706.1
      UniProtKB/TrEMBL
      A0A0C4DGQ9
      Related
      ENSP00000469879.1, ENST00000595977.5
      Conserved Domains (3) summary
      sd00017
      Location:143163
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:169188
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:440
      KRAB; KRAB box
    2. NM_145276.3NP_660319.1  zinc finger protein 563 isoform 1

      See identical proteins and their annotated locations for NP_660319.1

      Status: VALIDATED

      Source sequence(s)
      AC012618, BC022523
      Consensus CDS
      CCDS12270.1
      UniProtKB/Swiss-Prot
      B2R9E7, Q8NAT7, Q8TA94
      Related
      ENSP00000293725.5, ENST00000293725.10
      Conserved Domains (3) summary
      COG5048
      Location:194472
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:227247
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:440
      KRAB; KRAB box

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      12317477..12347390 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011527700.3XP_011526002.1  zinc finger protein 563 isoform X2

      See identical proteins and their annotated locations for XP_011526002.1

      Conserved Domains (3) summary
      COG5048
      Location:157435
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:190210
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:175197
      zf-H2C2_2; Zinc-finger double domain
    2. XM_005259750.5XP_005259807.1  zinc finger protein 563 isoform X4

      Conserved Domains (5) summary
      smart00349
      Location:440
      KRAB; krueppel associated box
      COG5048
      Location:47238
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:81101
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:440
      KRAB; KRAB box
      pfam13465
      Location:96117
      zf-H2C2_2; Zinc-finger double domain
    3. XM_011527699.3XP_011526001.1  zinc finger protein 563 isoform X2

      See identical proteins and their annotated locations for XP_011526001.1

      Conserved Domains (3) summary
      COG5048
      Location:157435
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:190210
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:175197
      zf-H2C2_2; Zinc-finger double domain
    4. XM_011527698.3XP_011526000.1  zinc finger protein 563 isoform X1

      Conserved Domains (3) summary
      COG5048
      Location:162440
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:195215
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:180202
      zf-H2C2_2; Zinc-finger double domain
    5. XM_006722651.4XP_006722714.1  zinc finger protein 563 isoform X3

      Conserved Domains (5) summary
      smart00349
      Location:440
      KRAB; krueppel associated box
      COG5048
      Location:138416
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:171191
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:440
      KRAB; KRAB box
      pfam13465
      Location:156178
      zf-H2C2_2; Zinc-finger double domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      12445840..12475737 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054319883.1XP_054175858.1  zinc finger protein 563 isoform X2

    2. XM_054319886.1XP_054175861.1  zinc finger protein 563 isoform X4

    3. XM_054319885.1XP_054175860.1  zinc finger protein 563 isoform X3

    4. XM_054319884.1XP_054175859.1  zinc finger protein 563 isoform X2

    5. XM_054319882.1XP_054175857.1  zinc finger protein 563 isoform X1