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    GLRX3 glutaredoxin 3 [ Homo sapiens (human) ]

    Gene ID: 10539, updated on 2-Nov-2024

    Summary

    Official Symbol
    GLRX3provided by HGNC
    Official Full Name
    glutaredoxin 3provided by HGNC
    Primary source
    HGNC:HGNC:15987
    See related
    Ensembl:ENSG00000108010 MIM:612754; AllianceGenome:HGNC:15987
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GRX3; GRX4; GLRX4; PICOT; TXNL2; TXNL3
    Summary
    This gene encodes a member of the glutaredoxin family. Glutaredoxins are oxidoreductase enzymes that reduce a variety of substrates using glutathione as a cofactor. The encoded protein binds to and modulates the function of protein kinase C theta. The encoded protein may also inhibit apoptosis and play a role in cellular growth, and the expression of this gene may be a marker for cancer. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 9. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]
    Expression
    Ubiquitous expression in testis (RPKM 12.3), lymph node (RPKM 8.3) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See GLRX3 in Genome Data Viewer
    Location:
    10q26.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (130136391..130180377)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (131065390..131109374)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (131934655..131978641)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724883 Neighboring gene uncharacterized LOC124902560 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:131919446-131919946 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:131919947-131920447 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_11122 Neighboring gene uncharacterized LOC105378561 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_11124 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2942 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4210 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:131935765-131936400 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:131936401-131937035 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4211 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4212 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4213 Neighboring gene peptidylprolyl isomerase A pseudogene 32 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:131966412-131966912 Neighboring gene uncharacterized LOC124902561 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:131988091-131988591 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2944 Neighboring gene zinc finger protein 717 pseudogene Neighboring gene uncharacterized LOC124900609

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Common human genetic variants and HIV-1 susceptibility: a genome-wide survey in a homogeneous African population.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • FLJ11864

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding PubMed 
    enables identical protein binding PubMed 
    enables iron-sulfur cluster binding  
    enables metal ion binding  
    enables protein binding PubMed 
    enables protein kinase C binding  
    Component Evidence Code Pubs
    located_in Z disc  
    located_in cell cortex  
    located_in cytoplasm PubMed 
    is_active_in cytosol  
    located_in dendrite  
    part_of iron-sulfur cluster assembly complex PubMed 
    is_active_in nucleus  
    located_in nucleus PubMed 

    General protein information

    Preferred Names
    glutaredoxin-3
    Names
    PKC-interacting cousin of thioredoxin
    PKC-theta-interacting protein
    PKCq-interacting protein
    glutaredoxin 4
    testicular tissue protein Li 75
    thioredoxin-like protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029886.1 RefSeqGene

      Range
      5017..48298
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001199868.2NP_001186797.1  glutaredoxin-3 isoform 1

      See identical proteins and their annotated locations for NP_001186797.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AF118652, AK022131, AL139123, BI256922
      Consensus CDS
      CCDS7661.1
      UniProtKB/Swiss-Prot
      B3KMP7, B3KMQ5, D3DRG2, O76003, Q5JV01, Q96CE0, Q9P1B0, Q9P1B1
      UniProtKB/TrEMBL
      A0A140VJK1
      Related
      ENSP00000357633.1, ENST00000368644.5
      Conserved Domains (2) summary
      cd02984
      Location:18113
      TRX_PICOT; TRX domain, PICOT (for PKC-interacting cousin of TRX) subfamily; PICOT is a protein that interacts with protein kinase C (PKC) theta, a calcium independent PKC isoform selectively expressed in skeletal muscle and T lymphocytes. PICOT contains an ...
      cd03028
      Location:137225
      GRX_PICOT_like; Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain ...
    2. NM_001321980.2NP_001308909.1  glutaredoxin-3 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL139123
      Conserved Domains (1) summary
      cd03028
      Location:93181
      GRX_PICOT_like; Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain ...
    3. NM_006541.5NP_006532.2  glutaredoxin-3 isoform 1

      See identical proteins and their annotated locations for NP_006532.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AA995117, AL139123, BC005289, BP347054
      Consensus CDS
      CCDS7661.1
      UniProtKB/Swiss-Prot
      B3KMP7, B3KMQ5, D3DRG2, O76003, Q5JV01, Q96CE0, Q9P1B0, Q9P1B1
      UniProtKB/TrEMBL
      A0A140VJK1
      Related
      ENSP00000330836.5, ENST00000331244.10
      Conserved Domains (2) summary
      cd02984
      Location:18113
      TRX_PICOT; TRX domain, PICOT (for PKC-interacting cousin of TRX) subfamily; PICOT is a protein that interacts with protein kinase C (PKC) theta, a calcium independent PKC isoform selectively expressed in skeletal muscle and T lymphocytes. PICOT contains an ...
      cd03028
      Location:137225
      GRX_PICOT_like; Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      130136391..130180377
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      131065390..131109374
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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