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    ZNF33B zinc finger protein 33B [ Homo sapiens (human) ]

    Gene ID: 7582, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ZNF33Bprovided by HGNC
    Official Full Name
    zinc finger protein 33Bprovided by HGNC
    Primary source
    HGNC:HGNC:13097
    See related
    Ensembl:ENSG00000196693 MIM:194522; AllianceGenome:HGNC:13097
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KOX2; KOX31; ZNF11B
    Summary
    This gene encodes a member of the zinc finger family of proteins. This gene shows decreased expression in cumulus cells derived from patients undergoing controlled ovarian stimulation. This gene is present in a gene cluster with several related zinc finger genes in the pericentromeric region of chromosome 10. Pseudogenes have been identified on chromosomes 7 and 10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
    Expression
    Ubiquitous expression in thyroid (RPKM 8.1), kidney (RPKM 6.4) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    Location:
    10q11.21
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (42574169..42638570, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (43451702..43516055, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (43069617..43134018, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene FXYD domain containing ion transport regulator 6 pseudogene 1 Neighboring gene eukaryotic translation initiation factor 3 subunit L pseudogene 2 Neighboring gene RNA, U6 small nuclear 1170, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:43132780-43133648 Neighboring gene uncharacterized LOC105378268 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2311 Neighboring gene Sharpr-MPRA regulatory region 10386 Neighboring gene vomeronasal 1 receptor 54 pseudogene Neighboring gene long intergenic non-protein coding RNA 1518

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Zinc finger protein 33B demonstrates sex interaction with atopy-related markers in childhood asthma. Lee S, et al. Eur Respir J, 2023 Jan. PMID 35953101, Free PMC Article
    2. Hormonal and molecular characterization of follicular fluid, cumulus cells and oocytes from pre-ovulatory follicles in stimulated and unstimulated cycles. de los Santos MJ, et al. Hum Reprod, 2012 Jun. PMID 22451503
    3. A cluster of expressed zinc finger protein genes in the pericentromeric region of human chromosome 10. Rousseau-Merck MF, et al. Genomics, 1992 Jul. PMID 1639412
    4. Genomic sequence and transcriptional profile of the boundary between pericentromeric satellites and genes on human chromosome arm 10p. Guy J, et al. Genome Res, 2003 Feb. PMID 12566394, Free PMC Article
    5. Duplicated KOX zinc finger gene clusters flank the centromere of human chromosome 10: evidence for a pericentric inversion during primate evolution. Tunnacliffe A, et al. Nucleic Acids Res, 1993 Mar 25. PMID 8464732, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Zinc finger protein 33B demonstrates sex interaction with atopy-related markers in childhood asthma.
      Title: Zinc finger protein 33B demonstrates sex interaction with atopy-related markers in childhood asthma.
    2. Observational study of gene-disease association. (HuGE Navigator)
      Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ23327, MGC129696

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 33B
    Names
    zinc finger protein 11b (KOX 2)
    zinc finger protein 33b (KOX 31)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305033.2 → NP_001291962.1  zinc finger protein 33B isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AJ491697, AK310073, BG536481
      UniProtKB/Swiss-Prot
      Q06732
      Related
      ENSP00000481265.1, ENST00000613419.4
      Conserved Domains (6) summary
      smart00349
      Location:19 → 78
      KRAB; krueppel associated box
      COG5048
      Location:336 → 681
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:366 → 386
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:476 → 498
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:19 → 58
      KRAB; KRAB box
      pfam13465
      Location:378 → 403
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001305035.2 → NP_001291964.1  zinc finger protein 33B isoform 3

      See identical proteins and their annotated locations for NP_001291964.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and initiates translation at an in-frame downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1. Variants 3-8 encode the same isoform (3).
      Source sequence(s)
      AJ491697, AK310073
      UniProtKB/Swiss-Prot
      Q06732
      Conserved Domains (3) summary
      COG5048
      Location:217 → 562
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:247 → 267
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:259 → 284
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001305036.2 → NP_001291965.1  zinc finger protein 33B isoform 3

      See identical proteins and their annotated locations for NP_001291965.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and initiates translation at an in-frame downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1. Variants 3-8 encode the same isoform (3).
      Source sequence(s)
      AJ491697, AK310073, DA230792
      UniProtKB/Swiss-Prot
      Q06732
      Conserved Domains (3) summary
      COG5048
      Location:217 → 562
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:247 → 267
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:259 → 284
      zf-H2C2_2; Zinc-finger double domain

    4. NM_001305037.2 → NP_001291966.1  zinc finger protein 33B isoform 3

      See identical proteins and their annotated locations for NP_001291966.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and initiates translation at an in-frame downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1. Variants 3-8 encode the same isoform (3).
      Source sequence(s)
      AJ491697, AK310073, DB156590
      UniProtKB/Swiss-Prot
      Q06732
      Conserved Domains (3) summary
      COG5048
      Location:217 → 562
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:247 → 267
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:259 → 284
      zf-H2C2_2; Zinc-finger double domain

    5. NM_001305038.2 → NP_001291967.1  zinc finger protein 33B isoform 3

      See identical proteins and their annotated locations for NP_001291967.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and initiates translation at an in-frame downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1. Variants 3-8 encode the same isoform (3).
      Source sequence(s)
      AJ491697, AK310073, CD652356
      UniProtKB/Swiss-Prot
      Q06732
      Conserved Domains (3) summary
      COG5048
      Location:217 → 562
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:247 → 267
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:259 → 284
      zf-H2C2_2; Zinc-finger double domain

    6. NM_001305039.2 → NP_001291968.1  zinc finger protein 33B isoform 3

      See identical proteins and their annotated locations for NP_001291968.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and initiates translation at an in-frame downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1. Variants 3-8 encode the same isoform (3).
      Source sequence(s)
      AJ491697, AK310073, DA493121
      UniProtKB/Swiss-Prot
      Q06732
      Conserved Domains (3) summary
      COG5048
      Location:217 → 562
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:247 → 267
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:259 → 284
      zf-H2C2_2; Zinc-finger double domain

    7. NM_001305040.2 → NP_001291969.1  zinc finger protein 33B isoform 3

      See identical proteins and their annotated locations for NP_001291969.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR and initiates translation at an in-frame downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1. Variants 3-8 encode the same isoform (3).
      Source sequence(s)
      AJ491697, AK310073, DR000119
      UniProtKB/Swiss-Prot
      Q06732
      Conserved Domains (3) summary
      COG5048
      Location:217 → 562
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:247 → 267
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:259 → 284
      zf-H2C2_2; Zinc-finger double domain

    8. NM_006955.3 → NP_008886.1  zinc finger protein 33B isoform 2

      See identical proteins and their annotated locations for NP_008886.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, contains an alternate exon in the 5' coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter compared to isoform 1.
      Source sequence(s)
      AJ491697, AK310073
      Consensus CDS
      CCDS7198.1
      UniProtKB/Swiss-Prot
      Q06731, Q06732, Q32MA2, Q86XY8, Q8NDW3
      Related
      ENSP00000352444.2, ENST00000359467.8
      Conserved Domains (5) summary
      smart00349
      Location:12 → 71
      KRAB; krueppel associated box
      COG5048
      Location:329 → 674
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:359 → 379
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:12 → 51
      KRAB; KRAB box
      pfam13465
      Location:371 → 396
      zf-H2C2_2; Zinc-finger double domain

    RNA

    1. NR_130948.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) uses an alternate 5' and 3' exon structure, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AK096683, AK309564, AK310073, AL022345, BI258188

    2. NR_130949.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) uses an alternate 5' and 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK096683, AK310073, AL022345, BI258188
      Related
      ENST00000486187.5

    3. NR_130950.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) uses an alternate 5' and 3' exon structure, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AK096683, AK310073, AL022345, BI258188, DA959465

    4. NR_130951.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) uses an alternate 5' and 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK310073, BC042873, DA826003

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      42574169..42638570 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047425718.1 → XP_047281674.1  zinc finger protein 33B isoform X1

    2. XM_047425719.1 → XP_047281675.1  zinc finger protein 33B isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      43451702..43516055 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054366693.1 → XP_054222668.1  zinc finger protein 33B isoform X1

    2. XM_054366694.1 → XP_054222669.1  zinc finger protein 33B isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06732.2 GenPept UniProtKB/Swiss-Prot:Q06732

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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