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    KAT7 lysine acetyltransferase 7 [ Homo sapiens (human) ]

    Gene ID: 11143, updated on 2-Nov-2024

    Summary

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    Official Symbol
    KAT7provided by HGNC
    Official Full Name
    lysine acetyltransferase 7provided by HGNC
    Primary source
    HGNC:HGNC:17016
    See related
    Ensembl:ENSG00000136504 MIM:609880; AllianceGenome:HGNC:17016
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HBO1; HBOA; MYST2; ZC2HC7
    Summary
    The protein encoded by this gene is part of the multimeric HBO1 complex, which possesses histone H4-specific acetyltransferase activity. This activity is required for functional replication origins and is involved in transcriptional activation of some genes. In both cases, the acetylation of histone H4 helps unfold chromatin so that the DNA can be accessed and replicated or transcribed. [provided by RefSeq, Oct 2016]
    Expression
    Broad expression in testis (RPKM 37.1), bone marrow (RPKM 22.8) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See KAT7 in Genome Data Viewer
    Location:
    17q21.33
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (49788681..49835026)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (50651771..50698127)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (47866043..47912388)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984999 Neighboring gene NANOG hESC enhancer GRCh37_chr17:47695165-47695679 Neighboring gene speckle type BTB/POZ protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12366 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12367 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12368 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:47784629-47785262 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:47785263-47785896 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:47796530-47797090 Neighboring gene solute carrier family 35 member B1 Neighboring gene family with sequence similarity 117 member A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12370 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8674 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8675 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:47865191-47865964 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12372 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:47879701-47880202 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:47880203-47880702 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr17:47893039-47894031 Neighboring gene SRP14 pseudogene 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:47911219-47911431 Neighboring gene CRISPRi-validated cis-regulatory element chr17.3537 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:47938611-47939558 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:47941593-47942092 Neighboring gene uncharacterized LOC729220 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:47942923-47943617 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:47948287-47949230 Neighboring gene tachykinin precursor 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12373 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:47967128-47967965 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:47967966-47968802 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:47976271-47977012 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:47980751-47981252 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:47986569-47987069 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:47990385-47990940 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:47991434-47992633 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:47993407-47993919 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:48001781-48002290 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:48005674-48006873 Neighboring gene MPRA-validated peak2887 silencer Neighboring gene MRT4 homolog, ribosome maturation factor pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Deciphering structure, function and mechanism of lysine acetyltransferase HBO1 in protein acetylation, transcription regulation, DNA replication and its oncogenic properties in cancer. Lan R, et al. Cell Mol Life Sci, 2020 Feb. PMID 31535175, Free PMC Article
    2. The histone acetyltransferase HBO1 functions as a novel oncogenic gene in osteosarcoma. Gao YY, et al. Theranostics, 2021. PMID 33754016, Free PMC Article
    3. Functional analysis of HBO1 in tumor development and inhibitor screening. Guo LL, et al. Int J Mol Med, 2016 Jul. PMID 27247147
    4. HBO1 induces histone acetylation and is important for non-small cell lung cancer cell growth. Chen TF, et al. Int J Biol Sci, 2022. PMID 35637972, Free PMC Article
    5. Upregulated KAT7 in synovial fibroblasts promotes Th17 cell differentiation and infiltration in rheumatoid arthritis. Gao S, et al. Biochem Biophys Res Commun, 2017 Jul 22. PMID 28552525

    See all (141) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Spermidine metabolism regulates leukemia stem and progenitor cell function through KAT7 expression in patient-derived mouse models.
      Title: Spermidine metabolism regulates leukemia stem and progenitor cell function through KAT7 expression in patient-derived mouse models.
    2. Adipose Mesenchymal Stem Cell-derived Exosomes Enhanced Glycolysis through the SIX1/HBO1 Pathway against Oxygen and Glucose Deprivation Injury in Human Umbilical Vein Endothelial Cells.
      Title: Adipose Mesenchymal Stem Cell-derived Exosomes Enhanced Glycolysis through the SIX1/HBO1 Pathway against Oxygen and Glucose Deprivation Injury in Human Umbilical Vein Endothelial Cells.
    3. KAT7 serves as an oncogenic gene and regulates CCL3 expression via STAT1 signaling in osteosarcoma.
      Title: KAT7 serves as an oncogenic gene and regulates CCL3 expression via STAT1 signaling in osteosarcoma.
    4. HBO1 determines SMAD action in pluripotency and mesendoderm specification.
      Title: HBO1 determines SMAD action in pluripotency and mesendoderm specification.
    5. Histone acetylation by HBO1 (KAT7) activates Wnt/beta-catenin signaling to promote leukemogenesis in B-cell acute lymphoblastic leukemia.
      Title: Histone acetylation by HBO1 (KAT7) activates Wnt/β-catenin signaling to promote leukemogenesis in B-cell acute lymphoblastic leukemia.
    6. The lncRNA ADAMTS9-AS1/miR-185-5p/KAT7 ceRNA network inhibits cardiomyocyte hypertrophy in hypertrophic obstructive cardiomyopathy.
      Title: The lncRNA ADAMTS9-AS1/miR-185-5p/KAT7 ceRNA network inhibits cardiomyocyte hypertrophy in hypertrophic obstructive cardiomyopathy.
    7. KAT7 promotes radioresistance through upregulating PI3K/AKT signaling in breast cancer.
      Title: KAT7 promotes radioresistance through upregulating PI3K/AKT signaling in breast cancer.
    8. KAT7-mediated CANX (calnexin) crotonylation regulates leucine-stimulated MTORC1 activity.
      Title: KAT7-mediated CANX (calnexin) crotonylation regulates leucine-stimulated MTORC1 activity.
    9. KAT7 promoted gastric cancer progression through promoting YAP1 activation.
      Title: KAT7 promoted gastric cancer progression through promoting YAP1 activation.
    10. HBO1 induces histone acetylation and is important for non-small cell lung cancer cell growth.
      Title: HBO1 induces histone acetylation and is important for non-small cell lung cancer cell growth.
    Submit: New GeneRIF Correction See all GeneRIFs (63)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    integrase gag-pol Cellular acetyltransferase binds HIV-1 integrase both in vitro and in cells and acetylates three specific lysine's (K264, K266, K273) in the carboxy-terminus of integrase PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA replication origin binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H3 acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H3K14 acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H3K23 acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H3K4 acetyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables histone H4 acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H4 acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H4K12 acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables histone H4K16 acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H4K5 acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H4K8 acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication-dependent chromatin disassembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in internal peptidyl-lysine acetylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in natural killer cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of DNA replication IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription, elongation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of hematopoietic stem cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of protein localization to nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA replication IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated DNA replication initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cell growth IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cell growth ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of nucleotide-excision repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to actinomycin D IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to anisomycin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to dithiothreitol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to hydroxyurea IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to sorbitol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in stress-activated protein kinase signaling cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcription initiation-coupled chromatin remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    part_of histone H3-K14 acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of histone H3-K14 acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of histone acetyltransferase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    NOT located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in site of DNA damage IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    histone acetyltransferase KAT7
    Names
    K(lysine) acetyltransferase 7
    MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2
    MYST histone acetyltransferase 2
    histone acetyltransferase MYST2
    histone acetyltransferase binding to ORC1
    NP_001186084.1
    NP_001186085.1
    NP_001186086.1
    NP_001186087.1
    NP_001333635.1
    NP_008998.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051976.2 RefSeqGene

      Range
      5002..51347
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001199155.2 → NP_001186084.1  histone acetyltransferase KAT7 isoform 2

      See identical proteins and their annotated locations for NP_001186084.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC015795, AC027801
      Consensus CDS
      CCDS56035.1
      UniProtKB/TrEMBL
      A0A9L9PXJ9
      Related
      ENSP00000516419.1, ENST00000706506.1
      Conserved Domains (3) summary
      PLN00104
      Location:294 → 579
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd16378
      Location:209 → 262
      CcmH_N; N-terminal domain of cytochrome c-type biogenesis protein CcmH and related proteins
      pfam01530
      Location:184 → 212
      zf-C2HC; Zinc finger, C2HC type

    2. NM_001199156.2 → NP_001186085.1  histone acetyltransferase KAT7 isoform 3

      See identical proteins and their annotated locations for NP_001186085.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC015795, AC027801
      Consensus CDS
      CCDS56037.1
      UniProtKB/TrEMBL
      B3KVJ2
      Related
      ENSP00000413415.2, ENST00000454930.6
      Conserved Domains (2) summary
      PLN00104
      Location:185 → 470
      PLN00104; MYST -like histone acetyltransferase; Provisional
      pfam01530
      Location:53 → 73
      zf-C2HC; Zinc finger, C2HC type

    3. NM_001199157.2 → NP_001186086.1  histone acetyltransferase KAT7 isoform 4

      See identical proteins and their annotated locations for NP_001186086.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC015795, AC027801
      Consensus CDS
      CCDS56036.1
      UniProtKB/TrEMBL
      A0A9L9PX81
      Related
      ENSP00000424577.1, ENST00000509773.5
      Conserved Domains (3) summary
      PLN00104
      Location:214 → 499
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd16378
      Location:129 → 182
      CcmH_N; N-terminal domain of cytochrome c-type biogenesis protein CcmH and related proteins
      pfam01530
      Location:113 → 132
      zf-C2HC; Zinc finger, C2HC type

    4. NM_001199158.2 → NP_001186087.1  histone acetyltransferase KAT7 isoform 5

      See identical proteins and their annotated locations for NP_001186087.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks three alternate in-frame exons compared to variant 1. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC015795, AC027801
      Consensus CDS
      CCDS56038.1
      UniProtKB/TrEMBL
      A0A9L9PX81
      Related
      ENSP00000423385.1, ENST00000510819.5
      Conserved Domains (3) summary
      PLN00104
      Location:155 → 440
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd16378
      Location:70 → 123
      CcmH_N; N-terminal domain of cytochrome c-type biogenesis protein CcmH and related proteins
      pfam01530
      Location:53 → 73
      zf-C2HC; Zinc finger, C2HC type

    5. NM_001346706.2 → NP_001333635.1  histone acetyltransferase KAT7 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (6) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC015795, AC027801
      UniProtKB/TrEMBL
      A0A9L9PX81, A0A9L9PXR9
      Related
      ENSP00000516479.1, ENST00000706640.1
      Conserved Domains (2) summary
      PLN00104
      Location:244 → 529
      PLN00104; MYST -like histone acetyltransferase; Provisional
      pfam01530
      Location:113 → 132
      zf-C2HC; Zinc finger, C2HC type

    6. NM_007067.5 → NP_008998.1  histone acetyltransferase KAT7 isoform 1

      See identical proteins and their annotated locations for NP_008998.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC015795, AC027801
      Consensus CDS
      CCDS11554.1
      UniProtKB/Swiss-Prot
      B3KN74, B4DF85, B4DFB4, B4DFE0, B4DGY4, E7ER15, G5E9K7, O95251
      UniProtKB/TrEMBL
      A0AA34QVH8
      Related
      ENSP00000259021.4, ENST00000259021.9
      Conserved Domains (2) summary
      PLN00104
      Location:324 → 609
      PLN00104; MYST -like histone acetyltransferase; Provisional
      pfam01530
      Location:184 → 212
      zf-C2HC; Zinc finger, C2HC type

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      49788681..49835026
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      50651771..50698127
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O95251.1 GenPept UniProtKB/Swiss-Prot:O95251

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous