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    cd248a CD248 molecule, endosialin a [ Danio rerio (zebrafish) ]

    Gene ID: 323364, updated on 28-Oct-2024

    Summary

    Official Symbol
    cd248aprovided by ZNC
    Official Full Name
    CD248 molecule, endosialin aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-2084
    See related
    Ensembl:ENSDARG00000103713 AllianceGenome:ZFIN:ZDB-GENE-030131-2084
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb96b12; wu:fb96b12; zgc:162651
    Summary
    Predicted to enable extracellular matrix binding activity and extracellular matrix protein binding activity. Acts upstream of or within regulation of innate immune response and response to lipopolysaccharide. Predicted to be located in membrane. Predicted to be active in external side of plasma membrane. Is expressed in eye; head; pharyngeal arch; and somite. Orthologous to human CD248 (CD248 molecule). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
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    Genomic context

    See cd248a in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (18364190..18367273)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (18111923..18115006)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137496162 Neighboring gene Ras converting CAAX endopeptidase 1a Neighboring gene somatostatin receptor 1b Neighboring gene zinc finger protein 16 like

    Genomic regions, transcripts, and products

    General gene information

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables extracellular matrix binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables extracellular matrix protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in animal organ development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    CD248 molecule, endosialin a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099228.3NP_001092698.3  CD248 molecule, endosialin a precursor

      Status: VALIDATED

      Source sequence(s)
      BX323024
      UniProtKB/TrEMBL
      A0A0R4IKQ6, A0A8M1NDU1
      Related
      ENSDARP00000136522.1, ENSDART00000171606.3
      Conserved Domains (4) summary
      cd03600
      Location:32176
      CLECT_thrombomodulin_like; C-type lectin-like domain (CTLD) of the type found in human thrombomodulin(TM), Endosialin, C14orf27, and C1qR
      pfam12662
      Location:309332
      cEGF; Complement Clr-like EGF-like
      pfam14670
      Location:253288
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl00057
      Location:327363
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      18364190..18367273
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394682.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      228966..232049
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)