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    men1 multiple endocrine neoplasia I [ Danio rerio (zebrafish) ]

    Gene ID: 30130, updated on 28-Oct-2024

    Summary

    Official Symbol
    men1provided by ZNC
    Official Full Name
    multiple endocrine neoplasia Iprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-991110-12
    See related
    Ensembl:ENSDARG00000089456 AllianceGenome:ZFIN:ZDB-GENE-991110-12
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fc44c03; zgc:110510
    Summary
    Predicted to enable Y-form DNA binding activity; chromatin binding activity; and transcription cis-regulatory region binding activity. Acts upstream of or within negative regulation of DNA-templated transcription. Predicted to be located in chromatin. Predicted to be part of histone methyltransferase complex. Is expressed in several structures, including digestive system; endoderm; head mesenchyme; intermediate cell mass of mesoderm; and nervous system. Human ortholog(s) of this gene implicated in endocrine gland cancer (multiple); hyperparathyroidism; and multiple endocrine neoplasia type 1. Orthologous to human MEN1 (menin 1). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
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    Genomic context

    See men1 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (17691849..17712606, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (17439876..17460633, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137496253 Neighboring gene mitogen-activated protein kinase kinase kinase kinase 2 Neighboring gene reticulon 3 Neighboring gene zinc finger translocation associated

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables Y-form DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
     
    enables transcription cis-regulatory region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
     
    involved_in negative regulation of cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of histone methyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    menin
    Names
    endocrine neoplasia
    menin 1
    multiple endocrine neoplasia type 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_130953.1NP_571028.1  menin

      See identical proteins and their annotated locations for NP_571028.1

      Status: PROVISIONAL

      Source sequence(s)
      AF212919
      UniProtKB/TrEMBL
      Q9IAA9
      Related
      ENSDARP00000124872.1, ENSDART00000149047.3
      Conserved Domains (2) summary
      cd14456
      Location:3457
      Menin; Scaffolding protein menin encoded by the MEN1 gene
      pfam05053
      Location:2615
      Menin; Menin

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      17691849..17712606 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)