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    eif6 eukaryotic translation initiation factor 6 [ Danio rerio (zebrafish) ]

    Gene ID: 386850, updated on 18-Sep-2024

    Summary

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    Official Symbol
    eif6provided by ZNC
    Official Full Name
    eukaryotic translation initiation factor 6provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-031118-110
    See related
    Ensembl:ENSDARG00000020232 AllianceGenome:ZFIN:ZDB-GENE-031118-110
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    eIF-6; Itgb4bp; itgb4bp4; zgc:56562; wu:fc28a04; wu:ft88f05
    Summary
    Predicted to enable ribosomal large subunit binding activity. Predicted to be involved in assembly of large subunit precursor of preribosome and ribosome biogenesis. Predicted to act upstream of or within ribosome biogenesis and translation. Predicted to be located in cytoplasm and nucleus. Predicted to be part of preribosome, large subunit precursor. Predicted to be active in cytosol and nucleolus. Is expressed in several structures, including alar plate midbrain region; immature eye; nervous system; neural plate; and segmental plate. Orthologous to human EIF6 (eukaryotic translation initiation factor 6). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See eif6 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (52339637..52348629, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (52339638..52348630, complement)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene zinc finger CCCH-type containing 10 Neighboring gene extended synaptotagmin-like protein 1b Neighboring gene U2 spliceosomal RNA Neighboring gene si:ch211-239j9.1 Neighboring gene matrix metallopeptidase 24

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    2. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    3. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC56562

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ribosomal large subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosome binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in assembly of large subunit precursor of preribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cytosolic ribosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytosolic ribosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maturation of 5.8S rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maturation of LSU-rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal subunit export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 6
    Names
    integrin beta 4 binding protein
    NP_957238.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200944.1 → NP_957238.1  eukaryotic translation initiation factor 6

      Status: PROVISIONAL

      Source sequence(s)
      BC049488
      UniProtKB/Swiss-Prot
      Q6ZM19
      Related
      ENSDARP00000015326.7, ENSDART00000016890.9
      Conserved Domains (1) summary
      PTZ00136
      Location:1 → 244
      PTZ00136; eukaryotic translation initiation factor 6-like protein; Provisional

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      52339637..52348629 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZM19.1 GenPept UniProtKB/Swiss-Prot:Q6ZM19

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.