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    Mlh3 mutL homolog 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314320, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Mlh3provided by RGD
    Official Full Name
    mutL homolog 3provided by RGD
    Primary source
    RGD:1309227
    See related
    EnsemblRapid:ENSRNOG00000006699 AllianceGenome:RGD:1309227
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ATP hydrolysis activity; centromeric DNA binding activity; and chromatin binding activity. Predicted to be involved in mismatch repair. Predicted to act upstream of or within DNA damage response; meiotic nuclear division; and protein localization. Predicted to be located in male germ cell nucleus and nuclear lumen. Predicted to be part of mismatch repair complex. Human ortholog(s) of this gene implicated in Lynch syndrome; colorectal cancer; endometrial cancer; and hereditary nonpolyposis colorectal cancer type 7. Orthologous to human MLH3 (mutL homolog 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 56.4), Heart (RPKM 49.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mlh3 in Genome Data Viewer
    Location:
    6q31
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (110612535..110649408, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (104881483..104917686, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (109059386..109095876, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene metallothionein 1, pseudogene 4 Neighboring gene eukaryotic translation initiation factor 2B subunit beta Neighboring gene acylphosphatase 1 Neighboring gene zinc finger, C2HC-type containing 1C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The polymorphisms of miRNA-binding site in MLH3 and ERCC1 were linked to the risk of colorectal cancer in a case-control study. Zhang Q, et al. Cancer Med, 2018 Apr. PMID 29516665, Free PMC Article
    2. A role for MLH3 in hereditary nonpolyposis colorectal cancer. Wu Y, et al. Nat Genet, 2001 Oct. PMID 11586295
    3. Contributions by MutL homologues Mlh3 and Pms2 to DNA mismatch repair and tumor suppression in the mouse. Chen PC, et al. Cancer Res, 2005 Oct 1. PMID 16204034
    4. Novel and diverse functions of the DNA mismatch repair family in mammalian meiosis and recombination. Kolas NK, et al. Cytogenet Genome Res, 2004. PMID 15467367
    5. Meiotic arrest and aneuploidy in MLH3-deficient mice. Lipkin SM, et al. Nat Genet, 2002 Aug. PMID 12091911

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent DNA damage sensor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables centromeric DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mismatched DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within female meiosis I ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within male meiotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mismatch repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within mismatch repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within synaptonemal complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chiasma ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in condensed chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in condensed nuclear chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in male germ cell nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mismatch repair complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mismatch repair complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synaptonemal complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DNA mismatch repair protein Mlh3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108043.1 → NP_001101513.1  DNA mismatch repair protein Mlh3

      See identical proteins and their annotated locations for NP_001101513.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473982
      UniProtKB/TrEMBL
      A6JE18, A6JE19, D4ADG4
      Related
      ENSRNOP00000038334.3, ENSRNOT00000033493.5
      Conserved Domains (3) summary
      smart00853
      Location:1179 → 1359
      MutL_C; MutL C terminal dimerisation domain
      cd03486
      Location:206 → 349
      MutL_Trans_MLH3; transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH3 (MutL homologue 3). MLH3 belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain ...
      cd16926
      Location:9 → 192
      HATPase_MutL-MLH-PMS-like; Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, human MutL homologs (MLH/ PMS), and related domains

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      110612535..110649408 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006240312.5 → XP_006240374.1  DNA mismatch repair protein Mlh3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6APJ9, A6JE19
      Related
      ENSRNOP00000090967.1, ENSRNOT00000102201.2
      Conserved Domains (4) summary
      smart00853
      Location:1147 → 1327
      MutL_C; MutL C terminal dimerisation domain
      cd03486
      Location:206 → 349
      MutL_Trans_MLH3; MutL_Trans_MLH3: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH3 (MutL homologue 3). MLH3 belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to ...
      TIGR00585
      Location:1 → 326
      mutl; DNA mismatch repair protein MutL
      pfam02518
      Location:22 → 149
      HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

    2. XM_006240311.5 → XP_006240373.1  DNA mismatch repair protein Mlh3 isoform X1

      UniProtKB/TrEMBL
      A6JE19
      Conserved Domains (4) summary
      smart00853
      Location:1176 → 1356
      MutL_C; MutL C terminal dimerisation domain
      cd03486
      Location:206 → 349
      MutL_Trans_MLH3; MutL_Trans_MLH3: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH3 (MutL homologue 3). MLH3 belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to ...
      TIGR00585
      Location:1 → 326
      mutl; DNA mismatch repair protein MutL
      pfam02518
      Location:22 → 149
      HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

    3. XM_063261941.1 → XP_063118011.1  DNA mismatch repair protein Mlh3 isoform X4

    4. XM_006240313.5 → XP_006240375.1  DNA mismatch repair protein Mlh3 isoform X3

      UniProtKB/TrEMBL
      A6JE19
      Conserved Domains (3) summary
      cd03486
      Location:206 → 349
      MutL_Trans_MLH3; MutL_Trans_MLH3: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH3 (MutL homologue 3). MLH3 belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to ...
      TIGR00585
      Location:1 → 326
      mutl; DNA mismatch repair protein MutL
      pfam02518
      Location:22 → 149
      HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

    5. XM_006240314.5 → XP_006240376.1  DNA mismatch repair protein Mlh3 isoform X5

      UniProtKB/TrEMBL
      A6JE19
      Conserved Domains (3) summary
      cd03486
      Location:206 → 349
      MutL_Trans_MLH3; MutL_Trans_MLH3: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH3 (MutL homologue 3). MLH3 belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to ...
      TIGR00585
      Location:1 → 326
      mutl; DNA mismatch repair protein MutL
      pfam02518
      Location:22 → 149
      HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
    Nucleotide Protein Strain
    Heading Accession and Version

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