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    Gemin7 gem (nuclear organelle) associated protein 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499391, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Gemin7provided by RGD
    Official Full Name
    gem (nuclear organelle) associated protein 7provided by RGD
    Primary source
    RGD:1597035
    See related
    EnsemblRapid:ENSRNOG00000049772 AllianceGenome:RGD:1597035
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in spliceosomal snRNP assembly. Predicted to be located in Gemini of coiled bodies and cytosol. Predicted to be part of SMN complex. Orthologous to human GEMIN7 (gem nuclear organelle associated protein 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 30.9), Muscle (RPKM 30.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gemin7 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (88343032..88352473, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (79215054..79228769, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (80473966..80487976, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene NTPase, KAP family P-loop domain containing 1 Neighboring gene protein phosphatase 1, regulatory subunit 37 Neighboring gene zinc finger protein 296 Neighboring gene CLK4-associating serine/arginine rich protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex. Baccon J, et al. J Biol Chem, 2002 Aug 30. PMID 12065586
    2. Gemin5 delivers snRNA precursors to the SMN complex for snRNP biogenesis. Yong J, et al. Mol Cell, 2010 May 28. PMID 20513430, Free PMC Article
    3. An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs. Chari A, et al. Cell, 2008 Oct 31. PMID 18984161
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in spliceosomal snRNP assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spliceosomal snRNP assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Gemini of coiled bodies ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of SMN complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of SMN-Sm protein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Sm-like protein family complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    gem-associated protein 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109170.1 → NP_001102640.1  gem-associated protein 7 isoform 1

      See identical proteins and their annotated locations for NP_001102640.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473979
      UniProtKB/TrEMBL
      A6J8P9, M0R5G2
      Conserved Domains (1) summary
      cd11677
      Location:66 → 142
      Gemin7; Gemin 7

    2. NM_001430430.1 → NP_001417359.1  gem-associated protein 7 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6AGJ9, A6J8Q0

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      88343032..88352473 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006228461.5 → XP_006228523.1  gem-associated protein 7 isoform X2

      Related
      ENSRNOP00000092860.1, ENSRNOT00000100949.2
      Conserved Domains (2) summary
      cd11677
      Location:52 → 128
      Gemin7; Gemin 7
      pfam12901
      Location:10 → 27
      SUZ-C; SUZ-C motif

    2. XM_039088190.2 → XP_038944118.1  gem-associated protein 7 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AGJ9, A6J8Q0
      Related
      ENSRNOP00000095884.1, ENSRNOT00000102935.2
      Conserved Domains (2) summary
      cd11677
      Location:52 → 128
      Gemin7; Gemin 7
      pfam12901
      Location:10 → 27
      SUZ-C; SUZ-C motif

    3. XM_017589594.3 → XP_017445083.1  gem-associated protein 7 isoform X1

      Related
      ENSRNOP00000098839.1, ENSRNOT00000128210.1
      Conserved Domains (1) summary
      cd11677
      Location:68 → 144
      Gemin7; Gemin 7
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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