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    IGFBP4 insulin like growth factor binding protein 4 [ Homo sapiens (human) ]

    Gene ID: 3487, updated on 28-Oct-2024

    Summary

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    Official Symbol
    IGFBP4provided by HGNC
    Official Full Name
    insulin like growth factor binding protein 4provided by HGNC
    Primary source
    HGNC:HGNC:5473
    See related
    Ensembl:ENSG00000141753 MIM:146733; AllianceGenome:HGNC:5473
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BP-4; IBP4; IGFBP-4; HT29-IGFBP
    Summary
    This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in liver (RPKM 316.3), ovary (RPKM 298.9) and 21 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See IGFBP4 in Genome Data Viewer
    Location:
    17q21.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (40443450..40457725)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (41306951..41321232)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (38599702..38613977)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene DNA topoisomerase II alpha Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:38573807-38574332 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:38575812-38576354 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12146 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8491 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8492 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8493 Neighboring gene ribosomal protein L23a pseudogene 75 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:38627029-38627920 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:38627921-38628810 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:38636369-38637568 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:38637551-38637736 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:38646739-38647364 Neighboring gene tensin 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:38649729-38650230 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:38650231-38650730 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:38655417-38656288 Neighboring gene uncharacterized LOC105371773 Neighboring gene Sharpr-MPRA regulatory region 2600

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Pregnancy-associated plasma protein-A polymorphism and the risk of recurrent pregnancy loss. Suzuki K, et al. J Reprod Immunol, 2006 Jun. PMID 16540175
    2. Insulin-like growth factor binding protein-4 expression is dependent on the carbohydrate in the media in HT-29 cells. Corkins MR, et al. Growth Horm IGF Res, 2002 Jun. PMID 12163000
    3. Insulin-like growth factor (IGF)-independent effects of IGF binding protein-4 on human granulosa cell steroidogenesis. Wright RJ, et al. Biol Reprod, 2002 Sep. PMID 12193384
    4. Induction of Regulatory T Cells and Its Regulation with Insulin-like Growth Factor/Insulin-like Growth Factor Binding Protein-4 by Human Mesenchymal Stem Cells. Miyagawa I, et al. J Immunol, 2017 Sep 1. PMID 28724578
    5. IGF-binding protein-4: biochemical characteristics and functional consequences. Zhou R, et al. J Endocrinol, 2003 Aug. PMID 12904166

    See all (115) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Specific cleavage of IGFBP-4 by papp-a in nervous tissue.
      Title: Specific cleavage of IGFBP-4 by papp-a in nervous tissue.
    2. AKAP12 and IGFBP4 Are Prognostic Factors for Chronic Lymphocytic Leukemia.
      Title: AKAP12 and IGFBP4 Are Prognostic Factors for Chronic Lymphocytic Leukemia.
    3. Increased Levels of Circulating IGFBP4 and ANGPTL8 with a Prospective Role in Diabetic Nephropathy.
      Title: Increased Levels of Circulating IGFBP4 and ANGPTL8 with a Prospective Role in Diabetic Nephropathy.
    4. The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.
      Title: The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.
    5. m[6]A mRNA methylation regulates the ERK/NF-kappaB/AKT signaling pathway through the PAPPA/IGFBP4 axis to promote proliferation and tumor formation in endometrial cancer.
      Title: m(6)A mRNA methylation regulates the ERK/NF-κB/AKT signaling pathway through the PAPPA/IGFBP4 axis to promote proliferation and tumor formation in endometrial cancer.
    6. PAPP-A-Specific IGFBP-4 Proteolysis in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
      Title: PAPP-A-Specific IGFBP-4 Proteolysis in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
    7. Exosome-associated microRNA-375 induces cell proliferation by regulating IGFBP4 upon hepatitis C virus infection.
      Title: Exosome-associated microRNA-375 induces cell proliferation by regulating IGFBP4 upon hepatitis C virus infection.
    8. Functional characterization of a novel p.Ser76Thr variant in IGFBP4 that associates with body mass index in American Indians.
      Title: Functional characterization of a novel p.Ser76Thr variant in IGFBP4 that associates with body mass index in American Indians.
    9. Increased activity of the metalloproteinase PAPP-A promotes diabetes-induced glomerular hypertrophy.
      Title: Increased activity of the metalloproteinase PAPP-A promotes diabetes-induced glomerular hypertrophy.
    10. The Rise of IGFBP4 in People with Obstructive Sleep Apnea and Multilevel Sleep Surgery Recovers Its Basal Levels.
      Title: The Rise of IGFBP4 in People with Obstructive Sleep Apnea and Multilevel Sleep Surgery Recovers Its Basal Levels.
    Submit: New GeneRIF Correction See all GeneRIFs (62)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Using a yeast two-hybrid system, HIV-1 Tat has been shown to bind the human insulin-like growth factor binding protein 4, suggesting a role for this protein in mediating the biological activity of Tat during HIV-1 replication PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables insulin-like growth factor I binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables insulin-like growth factor II binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of insulin-like growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of glucose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of insulin-like growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to organic cyclic compound IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in type B pancreatic cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    insulin-like growth factor-binding protein 4
    Names
    IBP-4
    IGF-binding protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001552.3 → NP_001543.2  insulin-like growth factor-binding protein 4 precursor

      See identical proteins and their annotated locations for NP_001543.2

      Status: REVIEWED

      Source sequence(s)
      AC018629, BC016041, CN431519
      Consensus CDS
      CCDS11367.1
      UniProtKB/Swiss-Prot
      A0N9W2, B4E351, P22692, Q5U012, Q9UCL6
      Related
      ENSP00000269593.4, ENST00000269593.5
      Conserved Domains (2) summary
      smart00121
      Location:25 → 101
      IB; Insulin growth factor-binding protein homologues
      pfam00086
      Location:174 → 249
      Thyroglobulin_1; Thyroglobulin type-1 repeat

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      40443450..40457725
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      41306951..41321232
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P22692.2 GenPept UniProtKB/Swiss-Prot:P22692

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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