rbp3 retinol binding protein 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rbp3provided by ZNC
Official Full Name: retinol binding protein 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-990415-132
See related: Ensembl:ENSDARG00000059163 AllianceGenome:ZFIN:ZDB-GENE-990415-132
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: irbp
Summary: Enables all-trans-retinol binding activity and oleic acid binding activity. Predicted to act upstream of or within proteolysis. Is expressed in pineal complex and visual system. Human ortholog(s) of this gene implicated in retinitis pigmentosa 66. Orthologous to human RBP3 (retinol binding protein 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 12

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (2665054..2670160)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (2625942..2635427)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our study, which provides the first structure of an IRBP with bound ligand, supports a potential role for fatty acids in regulating retinoid binding.
Title: Structure of zebrafish IRBP reveals fatty acid binding.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables all-trans-retinol binding	IDA Inferred from Direct Assay more info	PubMed
enables oleic acid binding	IDA Inferred from Direct Assay more info	PubMed
enables retinol binding	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: retinol-binding protein 3

Names: interphotoreceptor retinoid-binding protein; irbp gene 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131451.2 → NP_571526.2 retinol-binding protein 3 precursor

Status: VALIDATED

Source sequence(s)

CR450691

UniProtKB/TrEMBL

A0A8M1P5I5, A0A8M3B762, F1Q9N9

Related

ENSDARP00000118871.2, ENSDART00000147532.3

Conserved Domains (1) summary

cd07563
Location:326 → 603

Peptidase_S41_IRBP; Interphotoreceptor retinoid-binding protein; serine protease family S41