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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_052961.1 RefSeqGene
- Range
-
4466..71389
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_001068.3 → NP_001059.2 DNA topoisomerase 2-beta isoform 2
See identical proteins and their annotated locations for NP_001059.2
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) contains an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
- Source sequence(s)
-
AB208879, BF514624, BM150930, X68060
- Consensus CDS
-
CCDS46776.1
- UniProtKB/TrEMBL
-
Q71UH4
- Related
- ENSP00000396704.2, ENST00000435706.6
- Conserved Domains (7) summary
-
- cd03365
Location:471 → 591
- TOPRIM_TopoIIA; TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of ...
- cd00187
Location:727 → 1187
- TOP4c; DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA ...
- cd03481
Location:281 → 433
- TopoIIA_Trans_ScTopoIIA; TopoIIA_Trans_ScTopoIIA: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topo IIA. S. cerevisiae Topo IIA is a homodimer encoded ...
- PTZ00108
Location:41 → 1466
- PTZ00108; DNA topoisomerase 2-like protein; Provisional
- pfam02518
Location:96 → 193
- HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
- pfam08070
Location:1503 → 1604
- DTHCT; DTHCT (NUC029) region
- pfam16898
Location:589 → 727
- TOPRIM_C; C-terminal associated domain of TOPRIM
-
NM_001330700.2 → NP_001317629.1 DNA topoisomerase 2-beta isoform 1
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
- Source sequence(s)
-
AC093416
- Consensus CDS
-
CCDS82746.1
- UniProtKB/Swiss-Prot
- Q02880, Q13600, Q9UMG8, Q9UQP8
- UniProtKB/TrEMBL
-
Q71UH4
- Related
- ENSP00000264331.4, ENST00000264331.9
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000003.12 Reference GRCh38.p14 Primary Assembly
- Range
-
25597905..25664907 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_047448821.1 → XP_047304777.1 DNA topoisomerase 2-beta isoform X2
- Related
- ENSP00000514098.1, ENST00000699043.1
-
XM_011534057.4 → XP_011532359.1 DNA topoisomerase 2-beta isoform X1
- UniProtKB/TrEMBL
-
Q71UH4
- Conserved Domains (7) summary
-
- cd03365
Location:476 → 596
- TOPRIM_TopoIIA; TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of ...
- cd00187
Location:732 → 1192
- TOP4c; DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA ...
- cd03481
Location:286 → 438
- TopoIIA_Trans_ScTopoIIA; TopoIIA_Trans_ScTopoIIA: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topo IIA. S. cerevisiae Topo IIA is a homodimer encoded ...
- PTZ00108
Location:46 → 1466
- PTZ00108; DNA topoisomerase 2-like protein; Provisional
- pfam02518
Location:101 → 198
- HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
- pfam08070
Location:1471 → 1572
- DTHCT; DTHCT (NUC029) region
- pfam16898
Location:594 → 732
- TOPRIM_C; C-terminal associated domain of TOPRIM
-
XM_047448822.1 → XP_047304778.1 DNA topoisomerase 2-beta isoform X3
- Related
- ENSP00000391112.1, ENST00000424225.1
Alternate T2T-CHM13v2.0
Genomic
-
NC_060927.1 Alternate T2T-CHM13v2.0
- Range
-
25600752..25667754 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054347709.1 → XP_054203684.1 DNA topoisomerase 2-beta isoform X2
-
XM_054347708.1 → XP_054203683.1 DNA topoisomerase 2-beta isoform X1
-
XM_054347710.1 → XP_054203685.1 DNA topoisomerase 2-beta isoform X3