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    ZSWIM8 zinc finger SWIM-type containing 8 [ Homo sapiens (human) ]

    Gene ID: 23053, updated on 18-Nov-2024

    Summary

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    Official Symbol
    ZSWIM8provided by HGNC
    Official Full Name
    zinc finger SWIM-type containing 8provided by HGNC
    Primary source
    HGNC:HGNC:23528
    See related
    Ensembl:ENSG00000214655 MIM:619213; AllianceGenome:HGNC:23528
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KIAA0913
    Summary
    Enables ubiquitin-like ligase-substrate adaptor activity. Involved in positive regulation of macromolecule metabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Part of Cul3-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis (RPKM 21.6), spleen (RPKM 16.0) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZSWIM8 in Genome Data Viewer
    Location:
    10q22.2
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (73785606..73801793)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (74657006..74673193)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (75545364..75561551)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984243 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3574 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3575 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:75543706-75543880 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3576 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2488 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:75548316-75549515 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 1 Neighboring gene NDST2-ZSWIM8-AS1 readthrough Neighboring gene ZSWIM8 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2489 Neighboring gene N-deacetylase and N-sulfotransferase 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2490 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:75574449-75574702 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:75579102-75579602 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:75579603-75580103 Neighboring gene calcium/calmodulin dependent protein kinase II gamma Neighboring gene MPRA-validated peak1013 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:75617818-75618318 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:75618319-75618819 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3577 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2491 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2492 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2493

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The ZSWIM8 ubiquitin ligase regulates neurodevelopment by guarding the protein quality of intrinsically disordered Dab1. Wang G, et al. Cereb Cortex, 2023 Mar 21. PMID 35989311
    2. A ubiquitin ligase mediates target-directed microRNA decay independently of tailing and trimming. Han J, et al. Science, 2020 Dec 18. PMID 33184234, Free PMC Article
    3. ZSWIM8 is a myogenic protein that partly prevents C2C12 differentiation. Okumura F, et al. Sci Rep, 2021 Oct 22. PMID 34686700, Free PMC Article
    4. A transcript finishing initiative for closing gaps in the human transcriptome. Sogayar MC, et al. Genome Res, 2004 Jul. PMID 15197164, Free PMC Article
    5. The ZSWIM8 ubiquitin ligase mediates target-directed microRNA degradation. Shi CY, et al. Science, 2020 Dec 18. PMID 33184237, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The conserved Pelado/ZSWIM8 protein regulates actin dynamics by promoting linear actin filament polymerization.
      Title: The conserved Pelado/ZSWIM8 protein regulates actin dynamics by promoting linear actin filament polymerization.
    2. ZSWIM8 is a myogenic protein that partly prevents C2C12 differentiation.
      Title: ZSWIM8 is a myogenic protein that partly prevents C2C12 differentiation.
    3. The ZSWIM8 ubiquitin ligase mediates target-directed microRNA degradation.
      Title: The ZSWIM8 ubiquitin ligase mediates target-directed microRNA degradation.
    4. A ubiquitin ligase mediates target-directed microRNA decay independently of tailing and trimming.
      Title: A ubiquitin ligase mediates target-directed microRNA decay independently of tailing and trimming.
    5. Observational study of gene-disease association. (HuGE Navigator)
      Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See Variation Viewer (GRCh37.p13)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ34302, KIAA0913, MGC168869, MGC168870, 4832404P21Rik

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of miRNA catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein quality control for misfolded or incompletely synthesized proteins IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in target-directed miRNA degradation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Cul2-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Cul3-RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger SWIM domain-containing protein 8
    Names
    Dorado
    Pelado

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001242487.2 → NP_001229416.1  zinc finger SWIM domain-containing protein 8 isoform 2

      See identical proteins and their annotated locations for NP_001229416.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AB020720, AC022400, BC040726, BC151206
      Consensus CDS
      CCDS60560.1
      UniProtKB/Swiss-Prot
      A7E2V4, B2RP37, O94987, Q17RS8, Q2TAB8, Q6P439, Q8IW81, Q8NB34, Q9H8F3
      UniProtKB/TrEMBL
      S4R393
      Related
      ENSP00000474748.1, ENST00000605216.5
      Conserved Domains (1) summary
      cl19527
      Location:131 → 263
      SWIM; SWIM zinc finger

    2. NM_001242488.2 → NP_001229417.1  zinc finger SWIM domain-containing protein 8 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses two alternate splice sites in the 3' coding region with the latter resulting in a frameshift, compared to variant 1. It encodes isoform 3, which has a longer and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AB020720, AC022400, BC040726, BC111006, BC151206
      UniProtKB/TrEMBL
      S4R393
      Conserved Domains (1) summary
      cl19527
      Location:131 → 263
      SWIM; SWIM zinc finger

    3. NM_001367799.1 → NP_001354728.1  zinc finger SWIM domain-containing protein 8 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC022400
      Consensus CDS
      CCDS91266.1
      UniProtKB/TrEMBL
      S4R393, S4R410
      Related
      ENSP00000474944.1, ENST00000604729.6

    4. NM_015037.4 → NP_055852.2  zinc finger SWIM domain-containing protein 8 isoform 1

      See identical proteins and their annotated locations for NP_055852.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform (1).
      Source sequence(s)
      AB020720, AC022400, AK023742, BC040726, BC151206
      Consensus CDS
      CCDS44440.1
      UniProtKB/TrEMBL
      S4R393
      Related
      ENSP00000381693.2, ENST00000398706.6
      Conserved Domains (1) summary
      cl19527
      Location:131 → 263
      SWIM; SWIM zinc finger

    RNA

    1. NR_160292.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC022400

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      73785606..73801793
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005269648.3 → XP_005269705.1  zinc finger SWIM domain-containing protein 8 isoform X1

      UniProtKB/TrEMBL
      S4R393
      Conserved Domains (1) summary
      cl19527
      Location:131 → 263
      SWIM; SWIM zinc finger

    2. XM_017015978.2 → XP_016871467.1  zinc finger SWIM domain-containing protein 8 isoform X2

      UniProtKB/TrEMBL
      S4R393

    3. XM_006717725.4 → XP_006717788.1  zinc finger SWIM domain-containing protein 8 isoform X11

      UniProtKB/TrEMBL
      S4R393
      Related
      ENSP00000474043.1, ENST00000603114.5
      Conserved Domains (1) summary
      cl19527
      Location:131 → 263
      SWIM; SWIM zinc finger

    4. XM_047424867.1 → XP_047280823.1  zinc finger SWIM domain-containing protein 8 isoform X10

    5. XM_047424860.1 → XP_047280816.1  zinc finger SWIM domain-containing protein 8 isoform X3

    6. XM_047424868.1 → XP_047280824.1  zinc finger SWIM domain-containing protein 8 isoform X12

    7. XM_047424861.1 → XP_047280817.1  zinc finger SWIM domain-containing protein 8 isoform X4

    8. XM_047424869.1 → XP_047280825.1  zinc finger SWIM domain-containing protein 8 isoform X13

    9. XM_047424870.1 → XP_047280826.1  zinc finger SWIM domain-containing protein 8 isoform X14

    10. XM_047424862.1 → XP_047280818.1  zinc finger SWIM domain-containing protein 8 isoform X5

    11. XM_005269655.4 → XP_005269712.1  zinc finger SWIM domain-containing protein 8 isoform X16

      UniProtKB/TrEMBL
      S4R393
      Conserved Domains (1) summary
      cl19527
      Location:131 → 263
      SWIM; SWIM zinc finger

    12. XM_047424865.1 → XP_047280821.1  zinc finger SWIM domain-containing protein 8 isoform X8

    13. XM_047424871.1 → XP_047280827.1  zinc finger SWIM domain-containing protein 8 isoform X15

    14. XM_047424863.1 → XP_047280819.1  zinc finger SWIM domain-containing protein 8 isoform X6

    15. XM_047424872.1 → XP_047280828.1  zinc finger SWIM domain-containing protein 8 isoform X17

    16. XM_047424866.1 → XP_047280822.1  zinc finger SWIM domain-containing protein 8 isoform X9

    17. XM_047424864.1 → XP_047280820.1  zinc finger SWIM domain-containing protein 8 isoform X7

    18. XM_011539544.2 → XP_011537846.1  zinc finger SWIM domain-containing protein 8 isoform X18

      UniProtKB/TrEMBL
      H7BZ52
      Related
      ENSP00000387828.2, ENST00000433366.6
      Conserved Domains (1) summary
      cl19527
      Location:131 → 263
      SWIM; SWIM zinc finger

    19. XM_047424874.1 → XP_047280830.1  zinc finger SWIM domain-containing protein 8 isoform X19

    20. XM_047424875.1 → XP_047280831.1  zinc finger SWIM domain-containing protein 8 isoform X20

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      74657006..74673193
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054365274.1 → XP_054221249.1  zinc finger SWIM domain-containing protein 8 isoform X1

    2. XM_054365275.1 → XP_054221250.1  zinc finger SWIM domain-containing protein 8 isoform X2

    3. XM_054365283.1 → XP_054221258.1  zinc finger SWIM domain-containing protein 8 isoform X11

    4. XM_054365282.1 → XP_054221257.1  zinc finger SWIM domain-containing protein 8 isoform X10

    5. XM_054365276.1 → XP_054221251.1  zinc finger SWIM domain-containing protein 8 isoform X3

    6. XM_054365284.1 → XP_054221259.1  zinc finger SWIM domain-containing protein 8 isoform X12

    7. XM_054365277.1 → XP_054221252.1  zinc finger SWIM domain-containing protein 8 isoform X4

    8. XM_054365285.1 → XP_054221260.1  zinc finger SWIM domain-containing protein 8 isoform X13

    9. XM_054365286.1 → XP_054221261.1  zinc finger SWIM domain-containing protein 8 isoform X14

    10. XM_054365278.1 → XP_054221253.1  zinc finger SWIM domain-containing protein 8 isoform X5

    11. XM_054365288.1 → XP_054221263.1  zinc finger SWIM domain-containing protein 8 isoform X16

    12. XM_054365280.1 → XP_054221255.1  zinc finger SWIM domain-containing protein 8 isoform X8

    13. XM_054365287.1 → XP_054221262.1  zinc finger SWIM domain-containing protein 8 isoform X15

    14. XM_054365279.1 → XP_054221254.1  zinc finger SWIM domain-containing protein 8 isoform X6

    15. XM_054365289.1 → XP_054221264.1  zinc finger SWIM domain-containing protein 8 isoform X17

    16. XM_054365281.1 → XP_054221256.1  zinc finger SWIM domain-containing protein 8 isoform X9

    17. XM_054365290.1 → XP_054221265.1  zinc finger SWIM domain-containing protein 8 isoform X18

    18. XM_054365291.1 → XP_054221266.1  zinc finger SWIM domain-containing protein 8 isoform X19

    19. XM_054365292.1 → XP_054221267.1  zinc finger SWIM domain-containing protein 8 isoform X20

    20. XM_054365293.1 → XP_054221268.1  zinc finger SWIM domain-containing protein 8 isoform X21

    21. XM_054365294.1 → XP_054221269.1  zinc finger SWIM domain-containing protein 8 isoform X22

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A7E2V4.1 GenPept UniProtKB/Swiss-Prot:A7E2V4

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