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    P2RX1 purinergic receptor P2X 1 [ Homo sapiens (human) ]

    Gene ID: 5023, updated on 28-Oct-2024

    Summary

    Official Symbol
    P2RX1provided by HGNC
    Official Full Name
    purinergic receptor P2X 1provided by HGNC
    Primary source
    HGNC:HGNC:8533
    See related
    Ensembl:ENSG00000108405 MIM:600845; AllianceGenome:HGNC:8533
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P2X1
    Summary
    The protein encoded by this gene belongs to the P2X family of G-protein-coupled receptors. These proteins can form homo-and heterotimers and function as ATP-gated ion channels and mediate rapid and selective permeability to cations. This protein is primarily localized to smooth muscle where binds ATP and mediates synaptic transmission between neurons and from neurons to smooth muscle and may being responsible for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. This protein may also be involved in promoting apoptosis. [provided by RefSeq, Jun 2013]
    Expression
    Broad expression in bone marrow (RPKM 20.3), urinary bladder (RPKM 20.1) and 15 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See P2RX1 in Genome Data Viewer
    Location:
    17p13.2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (3896592..3916465, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (3785217..3805777, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (3799886..3819759, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903897 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:3771089-3771590 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:3771591-3772090 Neighboring gene calcium/calmodulin dependent protein kinase kinase 1 Neighboring gene Sharpr-MPRA regulatory region 11291 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:3791367-3791886 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:3791887-3792408 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8022 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8023 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8024 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:3807108-3807786 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11522 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11523 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11524 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11525 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11526 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11527 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11528 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:3831158-3832357 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:3833185-3834129 Neighboring gene ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:3844399-3844898 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8025 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:3856267-3857115 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:3860613-3861517 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8026 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8027 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8028 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8029 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11529 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:3879079-3879915 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:3879916-3880751 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:3885316-3886231 Neighboring gene long intergenic non-protein coding RNA 1975

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Infection of CD4+ T cells with HIV-1 in the presence of inhibitors of P2X receptors greatly inhibits HIV-1 infection via both cell-free and cell-to-cell contact in a dose-dependent manner, suggesting P2X receptors interact with gp120/gp41 in viral entry PubMed
    env Interaction of the HIV-1 gp120 with macrophages triggers an increase in ATP release that stimulates purinergic receptor P2X(1), P2X(7), and P2Y(1) proteins and facilitates HIV entry and subsequent stages of viral replication PubMed
    Envelope transmembrane glycoprotein gp41 env Infection of CD4+ T cells with HIV-1 in the presence of inhibitors of P2X receptors greatly inhibits HIV-1 infection via both cell-free and cell-to-cell contact in a dose-dependent manner, suggesting P2X receptors interact with gp120/gp41 in viral entry PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables extracellularly ATP-gated monoatomic cation channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables extracellularly ATP-gated monoatomic cation channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ligand-gated calcium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables monoatomic cation channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables purinergic nucleotide receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables suramin binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in calcium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in calcium-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ceramide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in excitatory postsynaptic potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in insemination IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within monoatomic ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neuronal action potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in platelet activation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of calcium ion import across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in purinergic nucleotide receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of blood pressure IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of presynaptic cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of synaptic vesicle exocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of vascular associated smooth muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to ATP IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in serotonin secretion by platelet IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in synaptic transmission, glutamatergic IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in presynaptic active zone membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in secretory granule membrane TAS
    Traceable Author Statement
    more info
     
    located_in specific granule membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    P2X purinoceptor 1
    Names
    ATP receptor
    P2X receptor, subunit 1
    P2X1 receptor
    purinergic receptor P2X, ligand gated ion channel, 1
    purinergic receptor P2X1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012109.1 RefSeqGene

      Range
      5202..25075
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002558.4NP_002549.1  P2X purinoceptor 1

      See identical proteins and their annotated locations for NP_002549.1

      Status: REVIEWED

      Source sequence(s)
      AC005940, BC044657, BX644575
      Consensus CDS
      CCDS11040.1
      UniProtKB/Swiss-Prot
      P51575, Q9UK84
      UniProtKB/TrEMBL
      B2R876
      Related
      ENSP00000225538.3, ENST00000225538.4
      Conserved Domains (1) summary
      TIGR00863
      Location:1368
      P2X; cation transporter protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      3896592..3916465 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006721529.3XP_006721592.1  P2X purinoceptor 1 isoform X6

      UniProtKB/TrEMBL
      B2R876
      Conserved Domains (1) summary
      cl02993
      Location:1351
      P2X_receptor; ATP P2X receptor
    2. XM_011523897.3XP_011522199.1  P2X purinoceptor 1 isoform X2

      UniProtKB/TrEMBL
      B2R876
      Conserved Domains (1) summary
      TIGR00863
      Location:1388
      P2X; cation transporter protein
    3. XM_047436159.1XP_047292115.1  P2X purinoceptor 1 isoform X5

    4. XM_011523898.4XP_011522200.1  P2X purinoceptor 1 isoform X3

      UniProtKB/TrEMBL
      B2R876
      Conserved Domains (1) summary
      pfam00864
      Location:59389
      P2X_receptor; ATP P2X receptor
    5. XM_011523899.4XP_011522201.1  P2X purinoceptor 1 isoform X4

      UniProtKB/TrEMBL
      B2R876
      Conserved Domains (1) summary
      pfam00864
      Location:59386
      P2X_receptor; ATP P2X receptor
    6. XM_047436158.1XP_047292114.1  P2X purinoceptor 1 isoform X1

    7. XM_047436161.1XP_047292117.1  P2X purinoceptor 1 isoform X8

    8. XM_011523900.4XP_011522202.1  P2X purinoceptor 1 isoform X7

      Conserved Domains (1) summary
      cl02993
      Location:59187
      P2X_receptor; ATP P2X receptor
    9. XM_047436160.1XP_047292116.1  P2X purinoceptor 1 isoform X7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      3785217..3805777 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054316294.1XP_054172269.1  P2X purinoceptor 1 isoform X5

    2. XM_054316291.1XP_054172266.1  P2X purinoceptor 1 isoform X3

    3. XM_054316292.1XP_054172267.1  P2X purinoceptor 1 isoform X4

    4. XM_054316289.1XP_054172264.1  P2X purinoceptor 1 isoform X1

    5. XM_054316293.1XP_054172268.1  P2X purinoceptor 1 isoform X6

    6. XM_054316290.1XP_054172265.1  P2X purinoceptor 1 isoform X2

    7. XM_054316297.1XP_054172272.1  P2X purinoceptor 1 isoform X8

    8. XM_054316296.1XP_054172271.1  P2X purinoceptor 1 isoform X7

    9. XM_054316295.1XP_054172270.1  P2X purinoceptor 1 isoform X7