DUSP10 dual specificity phosphatase 10 [Homo sapiens (human)] - Gene

Summary

Official Symbol: DUSP10provided by HGNC
Official Full Name: dual specificity phosphatase 10provided by HGNC
Primary source: HGNC:HGNC:3065
See related: Ensembl:ENSG00000143507 MIM:608867; AllianceGenome:HGNC:3065
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MKP5; MKP-5
Summary: Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAP kinases, different tissue distribution and subcellular localization, and different modes of expression induction by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Expression: Broad expression in liver (RPKM 11.1), bone marrow (RPKM 10.7) and 22 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1q41

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (221701424..221742089, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (220941255..220981921, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (221874766..221915431, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DUSP10 is a novel immune-related biomarker connected with survival and cellular proliferation in lower-grade glioma.
Title: DUSP10 is a novel immune-related biomarker connected with survival and cellular proliferation in lower-grade glioma.
MiRNA-363-3p/DUSP10/JNK axis mediates chemoresistance by enhancing DNA damage repair in diffuse large B-cell lymphoma.
Title: MiRNA-363-3p/DUSP10/JNK axis mediates chemoresistance by enhancing DNA damage repair in diffuse large B-cell lymphoma.
De novo germline mutation in the dual specificity phosphatase 10 gene accelerates autoimmune diabetes.
Title: De novo germline mutation in the dual specificity phosphatase 10 gene accelerates autoimmune diabetes.
An allosteric site on MKP5 reveals a strategy for small-molecule inhibition.
Title: An allosteric site on MKP5 reveals a strategy for small-molecule inhibition.
SETD8 potentiates constitutive ERK1/2 activation via epigenetically silencing DUSP10 expression in pancreatic cancer.
Title: SETD8 potentiates constitutive ERK1/2 activation via epigenetically silencing DUSP10 expression in pancreatic cancer.
Gene overexpression and knockdown demonstrated that MKP-5 could alleviate glucolipotoxicity-induced apoptosis via the endoplasmic reticulum (ER) stress and mitochondrial apoptosis pathways owing to the altered regulation of caspase family members and ER stress-related molecules. MKP-5 is a main mediator for glucolipotoxicity-induced islet cell dysfunction and apoptosis, with JNK and P38 as critical downstream pathways.
Title: The protective role of the MKP-5-JNK/P38 pathway in glucolipotoxicity-induced islet β-cell dysfunction and apoptosis.
Study of genome-wide epigenetic changes in bronchial epithelial cells of asthmatic patients, following cells treatment with vitamin D3 and Poly (I:C)(a viral analogue) allows the identification of biologically plausible candidate genes for viral infections and asthma, such as DUSP10 and SLC44A1.
Title: Epigenome-wide effects of vitamin D on asthma bronchial epithelial cells.
High DUSP10 expression is associated with pulmonary fibrosis.
Title: Role of dual-specificity protein phosphatase DUSP10/MKP-5 in pulmonary fibrosis.
Data found DUSP10 downregulated by rhinovirus (RV) infection. siRNA-mediated knockdown of DUSP10 identified a role for the protein in negatively regulating inflammatory cytokine production in response to IL-1beta alone and in combination with RV, without any effect on RV replication. This study identifies DUSP10 as an important regulator of airway inflammation in respiratory viral infection.
Title: DUSP10 Negatively Regulates the Inflammatory Response to Rhinovirus through Interleukin-1β Signaling.
Our findings uncover novel associations of progressive supranuclear palsy with SLCO1A2 (rs11568563) and DUSP10 (rs6687758) variants
Title: Replication of progressive supranuclear palsy genome-wide association study identifies SLCO1A2 and DUSP10 as new susceptibility loci.

Submit: New GeneRIF Correction See all GeneRIFs (31)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic Variants Associated with Serum Thyroid Stimulating Hormone (TSH) Levels in European Americans and African Americans from the eMERGE Network. EBI GWAS Catalog EBI GWAS CatalogPubMed
Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk. EBI GWAS Catalog EBI GWAS CatalogPubMed
Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AL033755 (e-PCR)
- UniSTS:93558

SHGC-76391 (e-PCR)
- UniSTS:639

RH69568 (e-PCR)
- UniSTS:52635

SHGC-142873 (e-PCR)
- UniSTS:171713

SHGC-76392 (e-PCR)
- UniSTS:80837

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables JUN kinase binding	IDA Inferred from Direct Assay more info	PubMed
enables MAP kinase phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables MAP kinase phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables MAP kinase tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables MAP kinase tyrosine/serine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables mitogen-activated protein kinase p38 binding	IPI Inferred from Physical Interaction more info	PubMed
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine/threonine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in dephosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of JNK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of JNK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of JUN kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell migration	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of epithelial cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of epithelial cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of epithelium regeneration	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of oligodendrocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of p38MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of p38MAPK cascade	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of respiratory burst involved in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of stress-activated MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in oligodendrocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-threonine dephosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of regulatory T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in regulation of brown fat cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in stress-activated MAPK cascade	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: dual specificity protein phosphatase 10

Names: dual specificity phosphatase MKP-5; map kinase phosphatase 5; mitogen-activated protein kinase phosphatase 5; serine/threonine specific protein phosphatase

NP_009138.1

EC 3.1.3.16

EC 3.1.3.48

XP_016855636.1

EC 3.1.3.16

EC 3.1.3.48

XP_047298898.1

EC 3.1.3.16

EC 3.1.3.48

XP_047298904.1

EC 3.1.3.16

EC 3.1.3.48

XP_054189977.1

EC 3.1.3.16

EC 3.1.3.48

XP_054189978.1

EC 3.1.3.16

EC 3.1.3.48

XP_054189979.1

EC 3.1.3.16

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007207.6 → NP_009138.1 dual specificity protein phosphatase 10

See identical proteins and their annotated locations for NP_009138.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the functional protein.

Source sequence(s)

AI261880, BC031405, BC063826, BG720911

Consensus CDS

CCDS1528.1

UniProtKB/Swiss-Prot

D3DTB4, Q6GSI4, Q9H9Z5, Q9Y6W6

UniProtKB/TrEMBL

Q6IAR2

Related

ENSP00000355866.3, ENST00000366899.4

Conserved Domains (2) summary

cd00127
Location:321 → 459

DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

cd01446
Location:149 → 284

DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

RNA

NR_111939.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks two 5' exons, and contains an alternate 5'-terminal exon, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.

Source sequence(s)

AI261880, BC020608, BC063826

Related

ENST00000468085.5
NR_111940.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.

Source sequence(s)

AI261880, BC031405, BC063826, BG720911

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

221701424..221742089 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047442948.1 → XP_047298904.1 dual specificity protein phosphatase 10 isoform X3
XM_047442942.1 → XP_047298898.1 dual specificity protein phosphatase 10 isoform X1
XM_017000147.3 → XP_016855636.1 dual specificity protein phosphatase 10 isoform X2

Alternate T2T-CHM13v2.0

Genomic

NC_060925.1 Alternate T2T-CHM13v2.0

Range

220941255..220981921 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054334004.1 → XP_054189979.1 dual specificity protein phosphatase 10 isoform X3
XM_054334002.1 → XP_054189977.1 dual specificity protein phosphatase 10 isoform X1
XM_054334003.1 → XP_054189978.1 dual specificity protein phosphatase 10 isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_144728.2: Suppressed sequence

Description

NM_144728.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
NM_144729.2: Suppressed sequence

Description

NM_144729.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.