U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    CNOT4 CCR4-NOT transcription complex subunit 4 [ Homo sapiens (human) ]

    Gene ID: 4850, updated on 3-Nov-2024

    Summary

    Official Symbol
    CNOT4provided by HGNC
    Official Full Name
    CCR4-NOT transcription complex subunit 4provided by HGNC
    Primary source
    HGNC:HGNC:7880
    See related
    Ensembl:ENSG00000080802 MIM:604911; AllianceGenome:HGNC:7880
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NOT4; NOT4H; CLONE243
    Summary
    The protein encoded by this gene is a subunit of the CCR4-NOT complex, a global transcriptional regulator. The encoded protein interacts with CNOT1 and has E3 ubiquitin ligase activity. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]
    Expression
    Ubiquitous expression in testis (RPKM 8.1), brain (RPKM 5.5) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CNOT4 in Genome Data Viewer
    Location:
    7q33
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (135361795..135510102, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (136669704..136817325, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (135046547..135194850, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26713 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:134935285-134935435 Neighboring gene uncharacterized LOC107984123 Neighboring gene stimulated by retinoic acid 8 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26714 Neighboring gene solute carrier family 23 member 4, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr7:134998844-134999016 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:135023371-135023872 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:135023873-135024372 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:135032494-135032998 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:135065068-135065648 Neighboring gene succinate dehydrogenase complex subunit D pseudogene 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:135193920-135194825 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:135194826-135195730 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26718 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26719 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26720 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26721 Neighboring gene nucleoporin 205 Neighboring gene Sharpr-MPRA regulatory region 5720 Neighboring gene protein max-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    part_of CCR4-NOT complex  
    part_of CCR4-NOT complex PubMed 
    part_of CCR4-NOT complex PubMed 
    located_in cytosol  
    located_in nucleus  

    General protein information

    Preferred Names
    CCR4-NOT transcription complex subunit 4
    Names
    CCR4-associated factor 4
    E3 ubiquitin-protein ligase CNOT4
    NOT4 (negative regulator of transcription 4, yeast) homolog
    RING-type E3 ubiquitin transferase CNOT4
    potential transcriptional repressor NOT4Hp
    NP_001008226.1
    NP_001177776.1
    NP_001177777.1
    NP_001177778.1
    NP_001177779.1
    NP_001380299.1
    NP_001380300.1
    NP_001380301.1
    NP_001380302.1
    NP_001380303.1
    NP_001380304.1
    NP_037448.2
    XP_047276368.1
    XP_047276369.1
    XP_047276370.1
    XP_047276371.1
    XP_054214243.1
    XP_054214244.1
    XP_054214245.1
    XP_054214246.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008225.3NP_001008226.1  CCR4-NOT transcription complex subunit 4 isoform b

      See identical proteins and their annotated locations for NP_001008226.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 3' end of an exon and differs in the 3' UTR and coding sequence compared to variant 6. The resulting isoform (b) lacks an internal 3 aa segment and has a shorter and distinct C-terminus compared to isoform f.
      Source sequence(s)
      AC009331, AC083871, AL389980, DA247976
      Consensus CDS
      CCDS47719.1
      UniProtKB/TrEMBL
      A0A9L9PY48
      Related
      ENSP00000399108.2, ENST00000428680.6
      Conserved Domains (1) summary
      COG5175
      Location:14319
      MOT2; Transcriptional repressor [Transcription]
    2. NM_001190847.2NP_001177776.1  CCR4-NOT transcription complex subunit 4 isoform c

      See identical proteins and their annotated locations for NP_001177776.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 6. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform f.
      Source sequence(s)
      AC009331, AC083871, AK314540, DA247976, U71267
      Consensus CDS
      CCDS55164.1
      UniProtKB/TrEMBL
      A0A9L9PY48
      Related
      ENSP00000406777.2, ENST00000423368.6
      Conserved Domains (1) summary
      COG5175
      Location:14322
      MOT2; Transcriptional repressor [Transcription]
    3. NM_001190848.2NP_001177777.1  CCR4-NOT transcription complex subunit 4 isoform d

      See identical proteins and their annotated locations for NP_001177777.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 3' UTR and coding sequence compared to variant 6. The resulting isoform (d) has a shorter and distinct C-terminus compared to isoform f.
      Source sequence(s)
      AC009331, AC083871, AL389980, DA247976, U71268
      Consensus CDS
      CCDS55166.1
      UniProtKB/Swiss-Prot
      B7Z6I4, E7ET38, F8VQP3, O95339, O95627, O95628, Q8IYM7, Q8NCL0, Q9NPQ1, Q9NZN6
      UniProtKB/TrEMBL
      A0A9L9PY48
      Related
      ENSP00000326731.5, ENST00000315544.6
      Conserved Domains (1) summary
      COG5175
      Location:14322
      MOT2; Transcriptional repressor [Transcription]
    4. NM_001190849.2NP_001177778.1  CCR4-NOT transcription complex subunit 4 isoform e

      See identical proteins and their annotated locations for NP_001177778.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 6. The resulting isoform (e) has the same N- and C-termini but is 3 aa shorter compared to isoform f.
      Source sequence(s)
      AC009331, AC083871, AK314540, CA396599, DA247976
      Consensus CDS
      CCDS55167.1
      UniProtKB/Swiss-Prot
      O95628
      Related
      ENSP00000388491.1, ENST00000451834.5
      Conserved Domains (1) summary
      COG5175
      Location:14319
      MOT2; Transcriptional repressor [Transcription]
    5. NM_001190850.2NP_001177779.1  CCR4-NOT transcription complex subunit 4 isoform f

      See identical proteins and their annotated locations for NP_001177779.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) encodes the longest isoform (f).
      Source sequence(s)
      AC009331, AC083871, AK314540, CA396599, DA247976, U71267
      Consensus CDS
      CCDS55165.1
      UniProtKB/Swiss-Prot
      O95628
      Related
      ENSP00000445508.1, ENST00000541284.6
      Conserved Domains (1) summary
      COG5175
      Location:14322
      MOT2; Transcriptional repressor [Transcription]
    6. NM_001393370.1NP_001380299.1  CCR4-NOT transcription complex subunit 4 isoform f

      Status: REVIEWED

      Source sequence(s)
      AC009331, AC083871, KF458610
      Consensus CDS
      CCDS55165.1
      Conserved Domains (1) summary
      COG5175
      Location:14322
      MOT2; Transcriptional repressor [Transcription]
    7. NM_001393371.1NP_001380300.1  CCR4-NOT transcription complex subunit 4 isoform g

      Status: REVIEWED

      Source sequence(s)
      AC009331, AC083871, KF458610
      Conserved Domains (1) summary
      COG5175
      Location:14297
      MOT2; Transcriptional repressor [Transcription]
    8. NM_001393372.1NP_001380301.1  CCR4-NOT transcription complex subunit 4 isoform h

      Status: REVIEWED

      Source sequence(s)
      AC009331, AC083871, KF458610
      Conserved Domains (1) summary
      COG5175
      Location:14285
      MOT2; Transcriptional repressor [Transcription]
    9. NM_001393373.1NP_001380302.1  CCR4-NOT transcription complex subunit 4 isoform i

      Status: REVIEWED

      Source sequence(s)
      AC009331, AC083871, KF458610
      Conserved Domains (1) summary
      COG5175
      Location:14256
      MOT2; Transcriptional repressor [Transcription]
    10. NM_001393374.1NP_001380303.1  CCR4-NOT transcription complex subunit 4 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC009331, AC083871, KF458610
      Consensus CDS
      CCDS43650.1
      UniProtKB/TrEMBL
      A0A9L9PY48
      Conserved Domains (1) summary
      COG5175
      Location:14319
      MOT2; Transcriptional repressor [Transcription]
    11. NM_001393375.1NP_001380304.1  CCR4-NOT transcription complex subunit 4 isoform k

      Status: REVIEWED

      Source sequence(s)
      AC009331, AC083871, KF458610
      UniProtKB/TrEMBL
      A0A9L9PY48
      Conserved Domains (1) summary
      COG5175
      Location:14285
      MOT2; Transcriptional repressor [Transcription]
    12. NM_013316.4NP_037448.2  CCR4-NOT transcription complex subunit 4 isoform a

      See identical proteins and their annotated locations for NP_037448.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) uses an alternate in-frame splice junction at the 3' end of an exon and lacks an alternate in-frame exon compared to variant 6. The resulting isoform (a) has the same N- and C-termini but is shorter compared to isoform f.
      Source sequence(s)
      AC009331, AC083871, AK314540, DA247976
      Consensus CDS
      CCDS43650.1
      UniProtKB/TrEMBL
      A0A9L9PY48
      Related
      ENSP00000354673.4, ENST00000361528.8
      Conserved Domains (1) summary
      COG5175
      Location:14319
      MOT2; Transcriptional repressor [Transcription]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      135361795..135510102 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047420412.1XP_047276368.1  CCR4-NOT transcription complex subunit 4 isoform X1

    2. XM_047420413.1XP_047276369.1  CCR4-NOT transcription complex subunit 4 isoform X2

    3. XM_047420415.1XP_047276371.1  CCR4-NOT transcription complex subunit 4 isoform X4

    4. XM_047420414.1XP_047276370.1  CCR4-NOT transcription complex subunit 4 isoform X3

      UniProtKB/Swiss-Prot
      B7Z6I4, E7ET38, F8VQP3, O95339, O95627, O95628, Q8IYM7, Q8NCL0, Q9NPQ1, Q9NZN6
      Related
      ENSP00000516715.1, ENST00000707064.1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      136669704..136817325 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358268.1XP_054214243.1  CCR4-NOT transcription complex subunit 4 isoform X1

    2. XM_054358269.1XP_054214244.1  CCR4-NOT transcription complex subunit 4 isoform X2

    3. XM_054358271.1XP_054214246.1  CCR4-NOT transcription complex subunit 4 isoform X4

    4. XM_054358270.1XP_054214245.1  CCR4-NOT transcription complex subunit 4 isoform X3

      UniProtKB/Swiss-Prot
      B7Z6I4, E7ET38, F8VQP3, O95339, O95627, O95628, Q8IYM7, Q8NCL0, Q9NPQ1, Q9NZN6
    External link. Please review our privacy policy.