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    Zc4h2 zinc finger C4H2-type containing [ Rattus norvegicus (Norway rat) ]

    Gene ID: 367838, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Zc4h2provided by RGD
    Official Full Name
    zinc finger C4H2-type containingprovided by RGD
    Primary source
    RGD:1561708
    See related
    EnsemblRapid:ENSRNOG00000056735 AllianceGenome:RGD:1561708
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561708
    Summary
    Predicted to be involved in nervous system development and positive regulation of neuron differentiation. Predicted to act upstream of or within noradrenergic neuron development; positive regulation of DNA-binding transcription factor activity; and protein monoubiquitination. Predicted to be located in cytoplasm; neuronal cell body; and postsynaptic membrane. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Miles-Carpenter syndrome. Orthologous to human ZC4H2 (zinc finger C4H2-type containing). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 64.2), Lung (RPKM 31.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zc4h2 in Genome Data Viewer
    Location:
    Xq22
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (64525725..64556037, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (60525706..60546519, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (64887978..64908682, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and SOCS box-containing 12 Neighboring gene ribosomal protein SA, pseudogene 14 Neighboring gene profilin-2-like Neighboring gene glutamic-oxaloacetic transaminase 2, pseudogene 6 Neighboring gene adenylosuccinate lyase, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ZC4H2 mutations are associated with arthrogryposis multiplex congenita and intellectual disability through impairment of central and peripheral synaptic plasticity. Hirata H, et al. Am J Hum Genet, 2013 May 2. PMID 23623388, Free PMC Article
    2. ZC4H2, an XLID gene, is required for the generation of a specific subset of CNS interneurons. May M, et al. Hum Mol Genet, 2015 Sep 1. PMID 26056227, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in nervous system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within noradrenergic neuron development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein monoubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger C4H2 domain-containing protein
    Names
    zinc finger, C4H2 domain containing

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001126374.2 → NP_001119846.1  zinc finger C4H2 domain-containing protein

      See identical proteins and their annotated locations for NP_001119846.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A8I6ABD4, B1WC48
      Conserved Domains (1) summary
      pfam10146
      Location:13 → 221
      zf-C4H2; Zinc finger-containing protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      64525725..64556037 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063280180.1 → XP_063136250.1  zinc finger C4H2 domain-containing protein isoform X1

    2. XM_063280181.1 → XP_063136251.1  zinc finger C4H2 domain-containing protein isoform X2

      UniProtKB/TrEMBL
      B1WC48

    3. XM_063280182.1 → XP_063136252.1  zinc finger C4H2 domain-containing protein isoform X5

    4. XM_039099948.2 → XP_038955876.1  zinc finger C4H2 domain-containing protein isoform X1

      UniProtKB/TrEMBL
      A0A8I6ABD4
      Related
      ENSRNOP00000072405.2, ENSRNOT00000084107.3
      Conserved Domains (1) summary
      pfam10146
      Location:17 → 224
      zf-C4H2; Zinc finger-containing protein

    5. XM_039099949.2 → XP_038955877.1  zinc finger C4H2 domain-containing protein isoform X3

      UniProtKB/TrEMBL
      A0A8I6ABD4
      Conserved Domains (1) summary
      pfam10146
      Location:1 → 198
      zf-C4H2; Zinc finger-containing protein

    6. XM_039099950.2 → XP_038955878.1  zinc finger C4H2 domain-containing protein isoform X4

      Conserved Domains (1) summary
      pfam10146
      Location:13 → 146
      zf-C4H2; Zinc finger-containing protein
    Nucleotide Protein Strain
    Heading Accession and Version

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