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    Abcb10 ATP binding cassette subfamily B member 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361439, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Abcb10provided by RGD
    Official Full Name
    ATP binding cassette subfamily B member 10provided by RGD
    Primary source
    RGD:1311222
    See related
    EnsemblRapid:ENSRNOG00000017993 AllianceGenome:RGD:1311222
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ATP binding activity; ATP hydrolysis activity; and protein homodimerization activity. Predicted to be involved in several processes, including mitochondrial unfolded protein response; positive regulation of erythrocyte differentiation; and positive regulation of hemoglobin biosynthetic process. Predicted to be located in mitochondrial inner membrane. Orthologous to human ABCB10 (ATP binding cassette subfamily B member 10). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 245.5), Muscle (RPKM 106.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Abcb10 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (68850108..68881689, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (51952655..51982910, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (56742809..56772904, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene nucleoporin 133 Neighboring gene uncharacterized LOC134483405 Neighboring gene small nucleolar RNA SNORA2/SNORA34 family Neighboring gene TATA-box binding protein associated factor 5 like 1 Neighboring gene URB2 ribosome biogenesis homolog Neighboring gene eukaryotic translation initiation factor 4E, pseudogene 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Targeting, import, and dimerization of a mammalian mitochondrial ATP binding cassette (ABC) transporter, ABCB10 (ABC-me). Graf SA, et al. J Biol Chem, 2004 Oct 8. PMID 15215243
    2. M-ABC2, a new human mitochondrial ATP-binding cassette membrane protein. Zhang F, et al. FEBS Lett, 2000 Jul 28. PMID 10922475
    3. ABC-me: a novel mitochondrial transporter induced by GATA-1 during erythroid differentiation. Shirihai OS, et al. EMBO J, 2000 Jun 1. PMID 10835348, Free PMC Article
    4. Proteomic analysis of the mouse liver mitochondrial inner membrane. Da Cruz S, et al. J Biol Chem, 2003 Oct 17. PMID 12865426
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109142

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in erythrocyte development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heme biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial unfolded protein response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of hemoglobin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ATP-binding cassette sub-family B member 10, mitochondrial
    Names
    ATP-binding cassette, sub-family B (MDR/TAP), member 10
    ATP-binding cassette, subfamily B (MDR/TAP), member 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012166.1 → NP_001012166.1  ATP-binding cassette sub-family B member 10, mitochondrial

      See identical proteins and their annotated locations for NP_001012166.1

      Status: PROVISIONAL

      Source sequence(s)
      BC089900
      UniProtKB/TrEMBL
      A0A8I6ATQ1, Q5FVL8
      Related
      ENSRNOP00000024232.3, ENSRNOT00000024232.6
      Conserved Domains (3) summary
      cd03249
      Location:458 → 698
      ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
      TIGR00958
      Location:10 → 694
      3a01208; Conjugate Transporter-2 (CT2) Family protein
      pfam00664
      Location:142 → 403
      ABC_membrane; ABC transporter transmembrane region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      68850108..68881689 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063278167.1 → XP_063134237.1  ATP-binding cassette sub-family B member 10, mitochondrial isoform X1

    2. XM_039097899.2 → XP_038953827.1  ATP-binding cassette sub-family B member 10, mitochondrial isoform X2

      Conserved Domains (2) summary
      cd18573
      Location:139 → 430
      ABC_6TM_ABCB10_like; Six-transmembrane helical domain (6-TMD) of the mitochondrial transporter ABCB10 (subfamily B, member 10) and similar proteins
      cl38936
      Location:458 → 521
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. XM_063278168.1 → XP_063134238.1  ATP-binding cassette sub-family B member 10, mitochondrial isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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