U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    l3mbtl2 L3MBTL histone methyl-lysine binding protein 2 [ Danio rerio (zebrafish) ]

    Gene ID: 568473, updated on 12-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    l3mbtl2provided by ZNC
    Official Full Name
    L3MBTL histone methyl-lysine binding protein 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-8713
    See related
    Ensembl:ENSDARG00000056079 AllianceGenome:ZFIN:ZDB-GENE-030131-8713
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:66491; im:7137244; wu:fb04e09
    Summary
    Predicted to enable chromatin binding activity and methylated histone binding activity. Predicted to be involved in negative regulation of transcription, DNA-templated. Predicted to act upstream of or within chromatin organization and regulation of transcription, DNA-templated. Predicted to be active in nucleus. Orthologous to human L3MBTL2 (L3MBTL histone methyl-lysine binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See l3mbtl2 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (18970830..18988131)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (18848916..18866753)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene E1A binding protein p300 a Neighboring gene transfer RNA glutamine (anticodon CUG) Neighboring gene chondroadherin-like b Neighboring gene Ran GTPase activating protein 1b

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The THAP domain of THAP1 is a large C2CH module with zinc-dependent sequence-specific DNA-binding activity. Clouaire T, et al. Proc Natl Acad Sci U S A, 2005 May 10. PMID 15863623, Free PMC Article
    2. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article
    3. Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. Diotel N, et al. J Comp Neurol, 2015 Jun 1. PMID 25556858, Free PMC Article
    4. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC66491

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    lethal(3)malignant brain tumor-like protein 2
    Names
    L3MBTL2, polycomb repressive complex 1 subunit
    l(3)mbt-like 2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200032.1 → NP_956326.1  lethal(3)malignant brain tumor-like protein 2

      See identical proteins and their annotated locations for NP_956326.1

      Status: PROVISIONAL

      Source sequence(s)
      BC057540
      UniProtKB/TrEMBL
      Q6PFI2
      Related
      ENSDARP00000072956.4, ENSDART00000078494.5
      Conserved Domains (3) summary
      smart00561
      Location:591 → 682
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam02820
      Location:511 → 582
      MBT; mbt repeat
      pfam05485
      Location:4 → 89
      THAP; THAP domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      18970830..18988131
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005156155.4 → XP_005156212.1  lethal(3)malignant brain tumor-like protein 2 isoform X1

      See identical proteins and their annotated locations for XP_005156212.1

      UniProtKB/TrEMBL
      A0A8M2B2U1, F1R4V8
      Related
      ENSDARP00000134087.1, ENSDART00000164212.3
      Conserved Domains (3) summary
      smart00561
      Location:591 → 682
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam02820
      Location:511 → 582
      MBT; mbt repeat
      pfam05485
      Location:4 → 89
      THAP; THAP domain

    2. XM_005156156.4 → XP_005156213.1  lethal(3)malignant brain tumor-like protein 2 isoform X2

      See identical proteins and their annotated locations for XP_005156213.1

      UniProtKB/TrEMBL
      A0A8M2B285
      Conserved Domains (3) summary
      smart00561
      Location:590 → 681
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam02820
      Location:510 → 581
      MBT; mbt repeat
      pfam05485
      Location:4 → 89
      THAP; THAP domain

    3. XM_005156157.4 → XP_005156214.1  lethal(3)malignant brain tumor-like protein 2 isoform X3

      See identical proteins and their annotated locations for XP_005156214.1

      UniProtKB/TrEMBL
      A0A8M2B270
      Conserved Domains (3) summary
      smart00561
      Location:504 → 595
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam02820
      Location:424 → 495
      MBT; mbt repeat
      pfam05485
      Location:4 → 89
      THAP; THAP domain

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395301.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      185339..207346
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools