celsr1a cadherin EGF LAG seven-pass G-type receptor 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: celsr1aprovided by ZNC
Official Full Name: cadherin EGF LAG seven-pass G-type receptor 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030616-78
See related: Ensembl:ENSDARG00000069185 AllianceGenome:ZFIN:ZDB-GENE-030616-78
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: EGF; LAG; frnt; CELSR; fmi1a; celsr1; zfmi1a; fb15b11; bZ22E02.1; wu:fb15b11; si:bz6l08.1
Summary: Predicted to enable G protein-coupled receptor activity and calcium ion binding activity. Acts upstream of or within cell migration involved in gastrulation; heart development; and neural tube development. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Is expressed in several structures, including axis; germ ring; heart; optic primordium; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human CELSR1 (cadherin EGF LAG seven-pass G-type receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 36

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (28191612..28335364, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	4	NC_007115.6 (28202324..28346070, complement)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

celsr1a is essential for tissue homeostasis and onset of aging phenotypes in the zebrafish.
Title: celsr1a is essential for tissue homeostasis and onset of aging phenotypes in the zebrafish.
Fmi/Celsr therefore has a dual role in mediating two separate morphogenetic movements through its roles in mediating cell cohesion and Wnt/PCP signalling during zebrafish gastrulation.
Title: Flamingo regulates epiboly and convergence/extension movements through cell cohesive and signalling functions during zebrafish gastrulation.

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Pathways from PubChem

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General gene information

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Markers

Z7524 (e-PCR)
- UniSTS:68496

fb15b11.x1 (e-PCR)
- UniSTS:190154

fb15b11.x1 (e-PCR)
- UniSTS:190155

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell migration involved in gastrulation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cell migration involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within heart development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within homophilic cell adhesion via plasma membrane adhesion molecules	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neural tube development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within tissue homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cadherin EGF LAG seven-pass G-type receptor 1; cadherin EGF LAG seven-pass G-type receptor 1a

Names: celsr4; flamingo 1a

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007115.7 Reference GRCz11 Primary Assembly

Range

28191612..28335364 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009300462.3 → XP_009298737.1 cadherin EGF LAG seven-pass G-type receptor 1 isoform X4

UniProtKB/TrEMBL

A0A8M3ARU0

Related

ENSDARP00000143939.1, ENSDART00000178149.2

Conserved Domains (12) summary

cd11304
Location:578 → 675

Cadherin_repeat; Cadherin tandem repeat domain

smart00008
Location:2042 → 2103

HormR; Domain present in hormone receptors

smart00180
Location:1993 → 2038

EGF_Lam; Laminin-type epidermal growth factor-like domai

cd00054
Location:1355 → 1390

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:1435 → 1618

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cd00185
Location:1915 → 1975

TNFRSF; CRD2 [structural motif]

pfam00002
Location:2447 → 2675

7tm_2; 7 transmembrane receptor (Secretin family)

pfam00008
Location:1644 → 1674

EGF; EGF-like domain

pfam01825
Location:2390 → 2435

GPS; GPCR proteolysis site, GPS, motif

pfam02210
Location:1710 → 1842

Laminin_G_2; Laminin G domain

pfam16489
Location:2121 → 2360

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

cl22855
Location:1874 → 2028

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
XM_009300461.3 → XP_009298736.1 cadherin EGF LAG seven-pass G-type receptor 1 isoform X3

UniProtKB/TrEMBL

A0A8M3B933

Conserved Domains (12) summary

cd11304
Location:578 → 675

Cadherin_repeat; Cadherin tandem repeat domain

smart00008
Location:2069 → 2130

HormR; Domain present in hormone receptors

smart00180
Location:2020 → 2065

EGF_Lam; Laminin-type epidermal growth factor-like domai

cd00054
Location:1355 → 1390

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:1435 → 1645

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cd00185
Location:1942 → 2002

TNFRSF; CRD2 [structural motif]

pfam00002
Location:2474 → 2702

7tm_2; 7 transmembrane receptor (Secretin family)

pfam00008
Location:1671 → 1701

EGF; EGF-like domain

pfam01825
Location:2417 → 2462

GPS; GPCR proteolysis site, GPS, motif

pfam02210
Location:1737 → 1869

Laminin_G_2; Laminin G domain

pfam16489
Location:2148 → 2387

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

cl22855
Location:1901 → 2055

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
XM_009300460.3 → XP_009298735.1 cadherin EGF LAG seven-pass G-type receptor 1 isoform X1

UniProtKB/TrEMBL

A0A8M3ARK0

Conserved Domains (12) summary

cd11304
Location:578 → 675

Cadherin_repeat; Cadherin tandem repeat domain

smart00008
Location:2069 → 2130

HormR; Domain present in hormone receptors

smart00180
Location:2020 → 2065

EGF_Lam; Laminin-type epidermal growth factor-like domai

cd00054
Location:1355 → 1390

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:1435 → 1645

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cd00185
Location:1942 → 2002

TNFRSF; CRD2 [structural motif]

pfam00002
Location:2474 → 2702

7tm_2; 7 transmembrane receptor (Secretin family)

pfam00008
Location:1671 → 1701

EGF; EGF-like domain

pfam01825
Location:2417 → 2462

GPS; GPCR proteolysis site, GPS, motif

pfam02210
Location:1737 → 1869

Laminin_G_2; Laminin G domain

pfam16489
Location:2148 → 2387

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

cl22855
Location:1901 → 2055

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
XM_005168547.4 → XP_005168604.1 cadherin EGF LAG seven-pass G-type receptor 1 isoform X2

UniProtKB/TrEMBL

A0A8M2BFV5, F1R9W4

Related

ENSDARP00000043736.5, ENSDART00000043737.5

Conserved Domains (12) summary

cd11304
Location:578 → 675

Cadherin_repeat; Cadherin tandem repeat domain

smart00008
Location:2069 → 2130

HormR; Domain present in hormone receptors

smart00180
Location:2020 → 2065

EGF_Lam; Laminin-type epidermal growth factor-like domai

cd00054
Location:1355 → 1390

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:1435 → 1645

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cd00185
Location:1942 → 2002

TNFRSF; CRD2 [structural motif]

pfam00002
Location:2474 → 2702

7tm_2; 7 transmembrane receptor (Secretin family)

pfam00008
Location:1671 → 1701

EGF; EGF-like domain

pfam01825
Location:2417 → 2462

GPS; GPCR proteolysis site, GPS, motif

pfam02210
Location:1737 → 1869

Laminin_G_2; Laminin G domain

pfam16489
Location:2148 → 2387

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

cl22855
Location:1901 → 2055

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)